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Triamcinolone acetonide-econazole cream and preparation method therefor

A technology of deconazole cream and microemulsion of deconazole, which is applied in ointment delivery, antifungal agent, pharmaceutical formulation, etc., can solve the problems of local stimulation bioavailability, liver toxicity, etc., and reduce the occurrence of adverse reactions High rate, less side effects, prolonged effect

Pending Publication Date: 2021-02-02
浙江得恩德制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although triamcinolone acetonide econazole cream is effective in the treatment of pathogenic fungi, it also has side effects such as systemic hepatotoxicity, local irritation and low bioavailability

Method used

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  • Triamcinolone acetonide-econazole cream and preparation method therefor
  • Triamcinolone acetonide-econazole cream and preparation method therefor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A, preparation of triamcinolone acetonide econazole microemulsion

[0035] Take triamcinolone acetonide 0.3g, econazole nitrate 3g, propylene glycol monocaprylate 30g, polyoxyethylene 40 hydrogenated castor oil 46.7g, polyoxyethylene 40 hydrogenated castor oil 20g and purified water 35g, propylene glycol monocaprylate at room temperature Caprylate, polyoxyethylene 40 hydrogenated castor oil, polyoxyethylene 40 hydrogenated castor oil were mixed and stirred evenly to obtain concentrated milk, then triamcinolone acetonide and econazole nitrate were added to the concentrated milk, and stirred to make triamcinolone acetonide and nitric acid benefit Conazole is completely dissolved in concentrated milk, and then slowly dripped into purified water under stirring conditions to obtain triamcinolone acetonide econazole microemulsion. The microemulsion is observed as a near sphere by transmission electron microscopy, and the particle size of the microemulsion is 35.5±2.5nm by las...

Embodiment 2

[0041] Preparation of triamcinolone acetonide econazole microemulsion

[0042] Take triamcinolone acetonide 0.3g, econazole nitrate 3g, propylene glycol monocaprylate 30g, polyoxyethylene 40 hydrogenated castor oil 46.7g, polyoxyethylene 40 hydrogenated castor oil 20g and purified water 50g, propylene glycol monocaprylate at room temperature Caprylate, polyoxyethylene 40 hydrogenated castor oil, polyoxyethylene 40 hydrogenated castor oil were mixed and stirred evenly to obtain concentrated milk, then triamcinolone acetonide and econazole nitrate were added to the concentrated milk, and stirred to make triamcinolone acetonide and nitric acid benefit Conazole is completely dissolved in concentrated milk, and then slowly dripped into purified water under stirring conditions to obtain triamcinolone acetonide econazole microemulsion. The microemulsion is observed as a near sphere by transmission electron microscopy, and the particle size of the microemulsion is 30.5±2.5nm by laser ...

Embodiment 3

[0048] Preparation of triamcinolone acetonide econazole microemulsion

[0049] Take by weighing triamcinolone acetonide 0.3g, econazole nitrate 3g, propylene glycol monocaprylate 30g, polyoxyethylene 40 hydrogenated castor oil 46.7g, polyoxyethylene 40 hydrogenated castor oil 20g and purified water 100g, propylene glycol monocaprylate at room temperature Caprylate, polyoxyethylene 40 hydrogenated castor oil, polyoxyethylene 40 hydrogenated castor oil were mixed and stirred evenly to obtain concentrated milk, then triamcinolone acetonide and econazole nitrate were added to the concentrated milk, and stirred to make triamcinolone acetonide and nitric acid benefit Conazole is completely dissolved in concentrated milk, and then slowly dripped into purified water under stirring conditions to obtain triamcinolone acetonide econazole microemulsion. The microemulsion is observed as a near sphere by transmission electron microscopy, and the particle size of the microemulsion is 32.5±2....

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Abstract

The invention discloses a triamcinolone acetonide-econazole microemulsion cream and a preparation method therefor. The microemulsion cream is obtained through uniformly mixing a triamcinolone acetonide econazole microemulsion, a cream matrix and a humectant. According to the triamcinolone acetonide-econazole microemulsion cream and the preparation method therefor, through adding a microparticle delivery system-microemulsion into the traditional cream, the skin retention of two kinds of drugs, i.e., triamcinolone acetonide and econazole nitrate is improved, the local drug concentration is improved, the treatment effect exerting time of the drugs is prolonged, skin irritation and side effects can also be alleviated, and the triamcinolone acetonide-econazole microemulsion cream is free of sensitization to skin of a healthy guinea pig.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a triamcinolone acetonide econazole cream and a preparation method thereof. Background technique [0002] Fungi exist in large quantities in nature, and pathogenic fungi are divided into deep fungi and superficial fungi. There are many kinds of pathogenic bacteria that can easily cause skin fungal infections. For heterosexual antigens, the body often has a more obvious allergic reaction to pathogenic fungi that invade the skin. Clinically, it can be manifested as eczema dermatitis-like appearance, itching, ringworm rash, and severe secondary bacterial infection. [0003] Triamcinolone acetonide econazole cream is a compound preparation of 0.1% triamcinolone acetonide and 1.0% econazole nitrate. Econazole nitrate is a broad-spectrum antifungal drug that is effective against dermatophytes, molds and yeasts. Good antibacterial activity, also has a g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K9/107A61K47/14A61K47/44A61K47/10A61K31/58A61K31/4174A61P31/10A61P17/00
CPCA61K9/06A61K9/1075A61K9/0014A61K47/14A61K47/44A61K47/10A61K31/58A61K31/4174A61P31/10A61P17/00A61K2300/00
Inventor 金春晖金鹿鸣潘伟红王学英
Owner 浙江得恩德制药股份有限公司
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