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Adjuvant composition for poultry and preparation method and application thereof

A technology of composition and vaccine composition, which is applied in the direction of medical preparations containing active ingredients, veterinary vaccines, pharmaceutical formulas, etc., can solve problems such as lack and aluminum residues, reduce immune interference, avoid residues, and ensure biological protection. safety effect

Pending Publication Date: 2021-02-02
LUOYANG SEIWEI BIOTECHNOLOGIES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The second problem with existing poultry vaccine adjuvants is that aluminum stearate is added as a stabilizer in the oil adjuvant, and aluminum stearate will cause potential aluminum residues
[0005] Therefore, the prior art lacks a poultry vaccine immune adjuvant that does not contain aluminum stearate, has no residue and safety risks, and can enhance the immune effect of the combined vaccine

Method used

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  • Adjuvant composition for poultry and preparation method and application thereof
  • Adjuvant composition for poultry and preparation method and application thereof
  • Adjuvant composition for poultry and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1, the preparation of DEAE dextran solution

[0045] Weigh DEAE dextran (molecular weight 5 × 10 5 ) 10.0 g, add 100 ml of water for injection, stir to make the DEAE dextran completely dissolve, and sterilize by autoclaving, the content is 10% w / v.

Embodiment 2

[0046] Embodiment 2, the preparation of ginseng stem and leaf saponin solution

[0047] 10 g of ginseng stem and leaf saponins was dissolved in distilled water, filtered through a 0.22-micron filter membrane, and prepared as a 10% (w / v) solution.

Embodiment 3

[0048] Embodiment 3 oil phase preparation

[0049] Add 6.5g of Siben-80 and 1.6g of Tween-85 to 75g of white oil, mix well, and prepare an oil phase.

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Abstract

The invention provides an adjuvant composition for poultry. The adjuvant composition comprises a water phase and an oil phase; the water phase contains 0.2 to 1.0% w / v of DEAE glucan and 0.1 to 1.0% w / v of ginserg stem and leaf faponins by the total volume of a vaccine composition. The invention further provides a vaccine composition containing the adjuvant composition. The vaccine composition canavoid antagonism in combined vaccines and significantly improve the immune effect of antigens.

Description

technical field [0001] The invention belongs to the technical field of biological products, in particular to an adjuvant composition. Background technique [0002] In order to reduce the stress response of chickens, combined vaccine immunization is usually used, such as recombinant avian influenza virus (H5+H7) bivalent inactivated vaccine, (H5N1 Re-11 strain + Re-12 strain, H7N9 H7-Re2 strain) trivalent vaccine Vaccine, chicken new tributary method quadruple inactivated vaccine (LaSota strain + M41 strain + SZ strain + rVP2 protein), but a typical problem of this type of vaccine is the immune interference between multiple antigens after immunization, resulting in the failure of combined vaccine immunity The effect is not as good as the corresponding single seedling. [0003] In order to solve this problem, two methods are usually adopted, one is to increase the content of the antigen, but increasing the content of the antigen correspondingly increases the production cost, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/39
CPCA61K39/39A61K2039/55577A61K2039/55583A61K2039/552
Inventor 田克恭刘永梅张许科
Owner LUOYANG SEIWEI BIOTECHNOLOGIES CO LTD
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