A kind of cationic liposome bird flu vaccine and preparation method thereof

A cationic lipid and influenza vaccine technology, which is applied in the field of cationic liposome avian influenza vaccine loaded with octadecylamine and its preparation, can solve inflammation, ulcer and granuloma, difficult metabolism of oily substances, and adverse reactions of oil adjuvant Serious problems, to achieve the effect of reducing adverse reactions, improving presentation ability, and enhancing strength

Active Publication Date: 2021-06-25
江苏飞阳益科生物科技有限公司
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Problems solved by technology

At present, the inactivated H9N2 subtype avian influenza vaccine is mainly prepared by mixing the semi-finished product of the inactivated H9N2 subtype avian influenza virus liquid with an oil adjuvant in an appropriate proportion, but the oil adjuvant has serious adverse reactions, and subcutaneous injection can cause Inflammation, ulcers and granulomas, and the long-term retention of oily substances in the tissues is not easy to metabolize, causing food safety problems for poultry meat products

Method used

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  • A kind of cationic liposome bird flu vaccine and preparation method thereof
  • A kind of cationic liposome bird flu vaccine and preparation method thereof
  • A kind of cationic liposome bird flu vaccine and preparation method thereof

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[0024] The above solution will be further described below in conjunction with specific embodiments. It should be understood that these examples are used to illustrate the present application and not limit the scope of the present application. The implementation conditions adopted in the examples can be further adjusted as the conditions of specific manufacturers, and the implementation conditions not indicated are usually the conditions in routine experiments. When used in the claims or description, the selected / optional / preferred "numeric range" not only includes the numerical endpoints at both ends of the range, but also includes all natural numbers covered in the middle of the numerical endpoints relative to the aforementioned numerical endpoints.

[0025] Nanotechnology is a cutting-edge technical discipline that has developed extremely rapidly in recent years. In particular, the use of nanomaterials and technologies to improve the function and efficiency of agricultural i...

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Abstract

The application discloses a preparation method of cationic liposome avian influenza vaccine. This method is based on the vaccine prepared by cationic liposomes loaded with octadecylamine, which can significantly improve the ability of antigen-presenting cells to present antigens, trigger CD4+ and CD8+ T cell responses, induce a strong inflammatory response, and improve memory T cells. Induction and increase its maintenance ability, the particle size of the vaccine is about 450nm, the encapsulation rate of the vaccine is above 50%, and under certain antigen concentrations, the encapsulation rate exceeds 70%. With the increase of the antigen concentration, the encapsulation rate The sealing rate is gradually increasing.

Description

technical field [0001] The application relates to the field of biotechnology, in particular to a cationic liposome avian influenza vaccine loaded with octadecylamine and a preparation method thereof. Background technique [0002] Adjuvants refer to substances that can enhance the body's immune response to antigens or change the type of immune response, and its main function is to enhance the response intensity and persistence of the body's immune system. Most of the existing vaccine adjuvants are oil adjuvants or aluminum gel adjuvants, which have problems such as large local irritation, many adverse reactions, poor vaccine stability, and low efficacy. The domestic white oil adjuvant technology is not high, and the quality is unstable. At present, the adjuvants used by my country's vaccine companies mainly rely on imports, resulting in a substantial increase in the production cost of vaccine preparations and product prices. Therefore, the development of new vaccine adjuvant...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/145A61K39/39A61K47/18A61K9/127A61K47/24A61K47/28A61P31/16
CPCA61K9/1271A61K39/12A61K39/39A61K47/18A61K47/24A61K47/28A61K2039/552A61K2039/55511A61K2039/55555A61K2039/575A61P31/16C12N2760/16134
Inventor 张亮孙飞跃王亚萍
Owner 江苏飞阳益科生物科技有限公司
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