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A kind of bismuth-manganese-based composite particle and its preparation method and application

A composite particle and composite nanoparticle technology, applied in the field of bismuth-manganese-based composite particles and their preparation, can solve the problems of poor treatment effect of cancer cells, less tumor site enrichment, lack of targeting ability, etc., and achieve chemodynamic therapy. , The effect of promoting photodynamic therapy and high drug loading rate

Active Publication Date: 2021-09-21
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

CuS@mSiO with core-shell structure 2 / ICG has a single function and can only provide photothermal therapy, and its structure is simple, the porosity is low, and the loading rate of organic molecule ICG is only about 8%. In addition, this material also lacks targeting ability and is enriched in tumor sites Less, affect the final treatment effect
MnO with hollow mesoporous structure 2 / Ce6 can improve the hypoxic environment and provide two treatment methods of photothermal and photodynamic, and the hollow mesoporous structure is relatively novel, and the porosity is relatively higher than that of CuS@mSiO with core-shell structure. 2 / ICG has been improved, but the loading rate of organic molecule Ce6 (chlorine e6) is only about 17%, and this material can only be passively targeted by adding a magnetic field from the outside, and the targeting efficiency is low. , Malignant cancer cells are less effective in treatment

Method used

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  • A kind of bismuth-manganese-based composite particle and its preparation method and application
  • A kind of bismuth-manganese-based composite particle and its preparation method and application
  • A kind of bismuth-manganese-based composite particle and its preparation method and application

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Embodiment 1

[0059] A kind of bismuth-manganese base composite particle, its preparation method comprises the following steps (synthesis schematic diagram is as follows figure 1 shown):

[0060] 1) Under the protection of argon, 0.9701g of Bi(NO 3 ) 3 ·5H 2 O was added to 10 mL of dodecanethiol, stirred for 10 min, then placed in an oil bath to heat up until the reaction solution turned black, kept for 1 min, washed the reaction solution with cyclohexane and ethanol, and then centrifuged at 10000 rpm for 10 min, and the precipitate was obtained. Bismuth nanoparticles (referred to as Bi NPs);

[0061] 2) Add 50 mg of bismuth nanoparticles into 50 mL of cyclohexane solution and disperse ultrasonically to obtain a dispersion of bismuth nanoparticles, then add 10 mL of emulsifier legal-CO-520 (alkylphenol ethoxylate) into 50 mL of cyclohexane In the hexane solution, mix evenly to obtain an emulsifier solution, then add the bismuth nanoparticle dispersion into the emulsifier solution, mix e...

Embodiment 2

[0098] A kind of bismuth-manganese base composite particle, its preparation method comprises the following steps (synthesis schematic diagram is as follows figure 1 shown):

[0099] 1) Under the protection of argon, 0.9701g of Bi(NO 3 ) 3 ·5H 2 O was added to 10 mL of dodecanethiol, stirred for 10 min, then placed in an oil bath to heat up until the reaction solution turned black, kept for 1 min, washed the reaction solution with cyclohexane and ethanol, and then centrifuged at 10000 rpm for 10 min, and the precipitate was obtained. Bismuth nanoparticles (referred to as Bi NPs);

[0100] 2) Add 50 mg of bismuth nanoparticles into 50 mL of cyclohexane solution and disperse ultrasonically to obtain a dispersion of bismuth nanoparticles, then add 10 mL of emulsifier legal-CO-520 (alkylphenol ethoxylate) into 50 mL of cyclohexane In the hexane solution, mix evenly to obtain an emulsifier solution, then add the bismuth nanoparticle dispersion into the emulsifier solution, mix e...

Embodiment 3

[0106] A kind of bismuth-manganese base composite particle, its preparation method comprises the following steps (synthesis schematic diagram is as follows figure 1 shown):

[0107] 1) Under the protection of argon, 0.315g of BiCl 3 Add 10mL of dodecanethiol, stir for 10min, then place in an oil bath to heat up until the reaction solution turns black, keep it warm for 1min, wash the reaction solution with cyclohexane and ethanol, then centrifuge at 10000rpm for 10min, take the precipitate, and obtain bismuth Nanoparticles (referred to as Bi NPs);

[0108] 2) Add 50 mg of bismuth nanoparticles into 50 mL of cyclohexane solution and disperse ultrasonically to obtain a dispersion of bismuth nanoparticles, then add 10 mL of emulsifier legal-CO-520 (alkylphenol ethoxylate) into 50 mL of cyclohexane In the hexane solution, mix evenly to obtain an emulsifier solution, then add the bismuth nanoparticle dispersion into the emulsifier solution, mix evenly, and then add 5 mL of KMnO wi...

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Abstract

The invention discloses a bismuth-manganese-based composite particle, a preparation method and application thereof. The composition of the bismuth-manganese-based composite particles of the present invention includes an inner core and a triple-negative breast cancer cell membrane wrapping the inner core; the inner core is formed by aggregating several amino-modified bismuth-bismuth trioxide-manganese oxide composite nanoparticles with a hollow structure; The interior and surface of the amino-modified bismuth-bismuth trioxide-manganese oxide composite nanoparticles with hollow structure are loaded with indocyanine green. The bismuth-manganese-based composite particle of the present invention has active targeting ability, can improve the tumor microenvironment and provide multiple treatment methods, has high drug loading rate, novel structure, and simple preparation method, and can be used for the treatment of larger and more malignant TNBC. treat.

Description

technical field [0001] The invention relates to the technical field of organic-inorganic composite biomaterials, in particular to a bismuth-manganese-based composite particle and a preparation method and application thereof. Background technique [0002] Breast cancer is a malignant tumor that occurs in the epithelial tissue of the mammary gland. At least 1 out of every 10 cancer patients in the world is a breast cancer patient, and 99% of breast cancer patients are women, which seriously threatens women's health. About 15%-20% of breast cancer patients suffer from triple negative breast cancer (TNBC) with a high mortality rate. TNBC refers to a special type of breast cancer that is clinically negative for estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER-2). TNBC has no specific receptors and antibodies, and has high invasiveness, recurrence rate and metastasis rate, and the curative effect of conventional treatment method...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K33/245A61K33/32A61K9/51A61K47/46A61P35/00
CPCA61K9/5176A61K33/245A61K33/32A61K41/0052A61K41/0057A61P35/00A61K2300/00
Inventor 李丽华徐兴毅
Owner SOUTH CHINA UNIV OF TECH
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