A kind of bismuth-manganese-based composite particle and its preparation method and application
A composite particle and composite nanoparticle technology, applied in the field of bismuth-manganese-based composite particles and their preparation, can solve the problems of poor treatment effect of cancer cells, less tumor site enrichment, lack of targeting ability, etc., and achieve chemodynamic therapy. , The effect of promoting photodynamic therapy and high drug loading rate
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Embodiment 1
[0059] A kind of bismuth-manganese base composite particle, its preparation method comprises the following steps (synthesis schematic diagram is as follows figure 1 shown):
[0060] 1) Under the protection of argon, 0.9701g of Bi(NO 3 ) 3 ·5H 2 O was added to 10 mL of dodecanethiol, stirred for 10 min, then placed in an oil bath to heat up until the reaction solution turned black, kept for 1 min, washed the reaction solution with cyclohexane and ethanol, and then centrifuged at 10000 rpm for 10 min, and the precipitate was obtained. Bismuth nanoparticles (referred to as Bi NPs);
[0061] 2) Add 50 mg of bismuth nanoparticles into 50 mL of cyclohexane solution and disperse ultrasonically to obtain a dispersion of bismuth nanoparticles, then add 10 mL of emulsifier legal-CO-520 (alkylphenol ethoxylate) into 50 mL of cyclohexane In the hexane solution, mix evenly to obtain an emulsifier solution, then add the bismuth nanoparticle dispersion into the emulsifier solution, mix e...
Embodiment 2
[0098] A kind of bismuth-manganese base composite particle, its preparation method comprises the following steps (synthesis schematic diagram is as follows figure 1 shown):
[0099] 1) Under the protection of argon, 0.9701g of Bi(NO 3 ) 3 ·5H 2 O was added to 10 mL of dodecanethiol, stirred for 10 min, then placed in an oil bath to heat up until the reaction solution turned black, kept for 1 min, washed the reaction solution with cyclohexane and ethanol, and then centrifuged at 10000 rpm for 10 min, and the precipitate was obtained. Bismuth nanoparticles (referred to as Bi NPs);
[0100] 2) Add 50 mg of bismuth nanoparticles into 50 mL of cyclohexane solution and disperse ultrasonically to obtain a dispersion of bismuth nanoparticles, then add 10 mL of emulsifier legal-CO-520 (alkylphenol ethoxylate) into 50 mL of cyclohexane In the hexane solution, mix evenly to obtain an emulsifier solution, then add the bismuth nanoparticle dispersion into the emulsifier solution, mix e...
Embodiment 3
[0106] A kind of bismuth-manganese base composite particle, its preparation method comprises the following steps (synthesis schematic diagram is as follows figure 1 shown):
[0107] 1) Under the protection of argon, 0.315g of BiCl 3 Add 10mL of dodecanethiol, stir for 10min, then place in an oil bath to heat up until the reaction solution turns black, keep it warm for 1min, wash the reaction solution with cyclohexane and ethanol, then centrifuge at 10000rpm for 10min, take the precipitate, and obtain bismuth Nanoparticles (referred to as Bi NPs);
[0108] 2) Add 50 mg of bismuth nanoparticles into 50 mL of cyclohexane solution and disperse ultrasonically to obtain a dispersion of bismuth nanoparticles, then add 10 mL of emulsifier legal-CO-520 (alkylphenol ethoxylate) into 50 mL of cyclohexane In the hexane solution, mix evenly to obtain an emulsifier solution, then add the bismuth nanoparticle dispersion into the emulsifier solution, mix evenly, and then add 5 mL of KMnO wi...
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