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56results about How to "For accurate visualization" patented technology

Method for reconstructing a fluorescent image of the interior of a turbid medium and device for imaging the interior of a turbid medium

A method for reconstructing a fluorescence image of the interior of a turbid medium is provided. The method comprises the step: accommodating a turbid medium (1) to which a fluorescent contrast agent has been administered in a measurement volume (4). The fluorescent contrast agent is capable of emitting light in a first range of wavelengths upon irradiation with light. The method further comprises: performing attenuation measurements at a plurality of different wavelengths (λi, . . . , λk) by subsequently irradiating the turbid medium (1) with light from a plurality of different source positions and detecting light emanating from the turbid medium (1) in a plurality of detection positions for each source position; reconstructing absorption properties (μa(r, λ) as a function of the position in the interior of the turbid medium (1) for the plurality of different wavelengths from the attenuation measurements; calculating absorption properties as a function of the position in the interior of the turbid medium (1) for wavelengths of the first range of wavelengths; performing a fluorescence measurement by subsequently irradiating the turbid medium (1) with light causing the fluorescent contrast agent to emit light in the first range of wavelengths from the plurality of source positions and detecting the light emanating from the fluorescent contrast agent in the plurality of detection positions for each source position; and reconstructing a fluorescence image of the spatial distribution of the fluorescent contrast agent in the interior of the turbid medium (1) from the fluorescence measurement using the calculated absorption properties.
Owner:KONINK PHILIPS ELECTRONICS NV

Preparation method of T1 strengthened nuclear magnetic resonance nanometer contrast agent

The invention discloses a T1 strengthened nanometer magnetic contrast agent having the function of activating targeting properties of blood platelets and a preparation method of the T1 strengthened nanometer magnetic contrast agent belonging to the field of nuclear magnetic resonance contrast agents. The characteristics of "dissociation-self-assembly" and surface modificability of an apoferritin nanometer cage under different pH environment are utilized, paramagnetic Gd-DOTA is loaded into the apoferritin nanometer cage, ligand-KGDS tetrapeptide specifically targeting and activating the bloodplatelets is coupled to the surface of Gd-loaded apoferritin, and therefore, nanometer particles which can actively target and activate the blood platelets and have nuclear magnetic resonance T1 weighted imaging strengthened contrast effects can be obtained. The particle diameter of the nanometer contrast agent is about 10nm, the nanometer contrast agent has favorable contrast effects, targeting properties for activating the blood platelets, and biocompatibility; precise visualization of thrombosis is hopefully realized through targeting and activating the blood platelets, and more comprehensive molecule information is provided for early prevention, diagnosis and treatment of cardiovascular diseases.
Owner:广州市番禺区中心医院

Method for reconstructing a fluorescent image of the interior of a turbid medium and device for imaging the interior of a turbid medium

A method for reconstructing a fluorescence image of the interior of a turbid medium is provided. The method comprises the step: accommodating a turbid medium (1) to which a fluorescent contrast agent has been administered in a measurement volume (4). The fluorescent contrast agent is capable of emitting light in a first range of wavelengths upon irradiation with light. The method further comprises: performing attenuation measurements at a plurality of different wavelengths (λi, . . . λk) by subsequently irradiating the turbid medium (1) with light from a plurality of different source positions and detecting light emanating from the turbid medium (1) in a plurality of detection positions for each source position; reconstructing absorption properties (μa(r, λ)) as a function of the position in the interior of the turbid medium (1) for the plurality of different wavelengths from the attenuation measurements; calculating absorption properties as a function of the position in the interior of the turbid medium (1) for wavelengths of the first range of wavelengths; performing a fluorescence measurement by subsequently irradiating the turbid medium (1) with light causing the fluorescent contrast agent to emit light in the first range of wavelengths from the plurality of source positions and detecting the light emanating from the fluorescent contrast agent in the plurality of detection positions for each source position; and reconstructing a fluorescence image of the spatial distribution of the fluorescent contrast agent in the interior of the turbid medium (1) from the fluorescence measurement using the calculated absorption properties.
Owner:KONINKLIJKE PHILIPS ELECTRONICS NV
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