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Florfenicol solution as well as preparation method and application thereof

A florfenicol and solution technology, which is applied in the field of florfenicol solution for pigs and its preparation, can solve the problems of decreased water consumption, inconvenient operation, uneven mixing and the like of pigs, and achieves blocking of taste receptors, reducing Adverse effects, reduced toxicity effects

Pending Publication Date: 2021-02-19
FOSHAN STANDARD BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it still does not solve the problem that the bitter taste of florfenicol leads to a decrease in the drinking water of pigs, and the compounding of florfenicol and polydopamine may affect the medicinal properties of florfenicol
[0008] At present, the florfenicol premix for pigs has the problems of inconvenient operation, uneven mixing, and inability to control the dosage well, and the florfenicol solution also has the problem of causing pigs to drink water due to the bitter taste of florfenicol. volume drop problem

Method used

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  • Florfenicol solution as well as preparation method and application thereof
  • Florfenicol solution as well as preparation method and application thereof
  • Florfenicol solution as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] The present embodiment provides a kind of florfenicol solution, and each component and proportioning ratio are as follows:

[0078] Florfenicol 30%

[0079] Pentaerythritol tetraacetate 2.25%

[0080] Mannitol 1.125%

[0081] DMF 1%

[0082] Lecithin 3%

[0083] Tween 80 4.5%

[0084] n-Butanol 4%

[0085] Isopropyl myristate (IPM) 18%

[0086] Sucrose 0.2%

[0087] Ike Bensweet 0.51%

[0088] Lemon Extract 0.29%

[0089] Pepper Extract 1%

[0090] water balance

[0091] The preparation method is as follows:

[0092] Heat the mixture of pentaerythritol tetraacetate and mannitol to 80°C, stir until it melts, add DMF and Florfenicol and stir at 750r / min for 40min until the mixture melts completely, and drug-loaded complex A is obtained. Mix lecithin, Tween 80, n-butanol, and isopropyl myristate (IPM) and stir at 750r / min for 40min until uniform to obtain oil phase B. Dissolve sucrose, ecstasy, lemon extract, and pepper extract in water to obtain aqueous phase...

Embodiment 2

[0094] The present embodiment provides a kind of florfenicol solution, and each component and proportioning ratio are as follows:

[0095] Florfenicol 40%

[0096] PEG 4000 4.5%

[0097] Fructitol 3%

[0098] DMF 2%

[0099] Lecithin 5%

[0100] Nonylphenol ethoxylate 5%

[0101] Isopropanol 3.5%

[0102] Olive oil 14%

[0103] Glycerin 0.44%

[0104] Sodium Saccharin 0.67%

[0105] Peppermint Extract 0.89%

[0106] Pepper Extract 1.5%

[0107] water balance

[0108] The preparation method is as follows:

[0109] Heat the mixture of PEG 4000 and fructitol to 58°C, stir until it melts, add DMF and Florfenicol and stir at 500r / min for 50min, until the mixture is completely melted, and the drug-loaded complex A is obtained. Nonylphenol polyoxyethylene ether was heated to 70°C, mixed with lecithin, isopropanol, and olive oil and stirred at 500r / min for 50min until uniform, and oil phase B was obtained. Dissolve glycerin, sodium saccharin, peppermint extract, and peppe...

Embodiment 3

[0111] The present embodiment provides a kind of florfenicol solution, and each component and proportioning ratio are as follows:

[0112] Florfenicol 50%

[0113] PEG 6000 5.25%

[0114] Alpha-Lactose 4.5%

[0115] Soy Lecithin 6%

[0116] Fatty acid glycerides 12%

[0117] Polyglycerides 2%

[0118] Polyoxyethylene hydrogenated castor oil (RH40) 8%

[0119] Simple Syrup 0.46%

[0120] Ike Bensweet 1.62%

[0121] Cinnamon Extract 0.42%

[0122] Pepper Extract 2%

[0123] water balance

[0124] The preparation method is as follows:

[0125] Heat the mixture of PEG 6000 and α-lactose to 60°C, stir until it melts, add florfenicol and stir at 1000r / min for 30min, until the mixture is completely melted, and the drug-loaded complex A is obtained. Soybean lecithin, fatty acid glycerides, polyglycerol esters, and polyoxyethylene hydrogenated castor oil (RH40) were mixed and stirred at 1000 r / min for 30 minutes until uniform, and oil phase B was obtained. Dissolve simple s...

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PUM

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Abstract

The invention provides a florfenicol solution as well as a preparation method and application thereof. The florfenicol solution comprises the following components of, in parts by weight, 10-55 parts of florfenicol, 2-12 parts of a drug carrier, 5-20 parts of an emulsifier, 1-7 parts of a co-emulsifier, 5-25 parts of grease, 0.5-5 part of a flavoring agent and 0.5-4 part of a taste blocker; and theflavoring agent comprises a sweetening agent and an aromatic. The florfenicol solution has the advantages of strong stability, high efficiency, safety, sour and sweet taste and wide application prospect, and can stimulate drinking water.

Description

technical field [0001] The invention belongs to the field of veterinary medicine and relates to a florfenicol solution and a preparation method and application thereof, in particular to a florfenicol solution for pigs and a preparation method and application thereof. Background technique [0002] Florfenicol, also known as florfenicol, is a new type of broad-spectrum antibacterial drug, which is widely used in aquaculture and animal husbandry, especially in the prevention and control of diseases caused by Actinobacillus pleuropneumoniae. In terms of treatment, it has irreplaceable economic value. [0003] At present, the main florfenicol preparations in the Veterinary Pharmacopoeia are: florfenicol soluble powder, florfenicol injection, florfenicol powder, florfenicol premix and florfenicol solution. Usually, florfenicol powder and florfenicol premix are administered as admixtures, which have problems such as inconvenient operation, uneven mixing, and inability to control t...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/165A61K47/10A61K47/12A61K47/14A61K47/24A61K47/26A61K47/44A61P31/04
CPCA61K31/165A61K9/107A61K9/0095A61K47/26A61K47/10A61K47/12A61K47/14A61K47/24A61K47/44A61P31/04
Inventor 赵一阳黎剑坤刘肖娟王振兴谭志坚符德文
Owner FOSHAN STANDARD BIO TECH