A drug-eluting intraocular lens with sustained-release function and its preparation method

An intraocular lens and drug technology, used in intraocular lens, drug devices, eye implants, etc., can solve the problems of difficult control of coating quality, effect greatly affected by coating stability, damage to structural strength, etc. Good drug release and biocompatibility, ensure foldability and stability, and prevent inflammation

Active Publication Date: 2022-03-08
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above methods can play a certain role in the prevention and treatment of complications to a certain extent, there are still some shortcomings: 1) the structural modification carried out by loading the drug release device on the intraocular lens loop has greatly damaged its structural strength; 2) The surface modification or drug loading in the optical zone of the intraocular lens greatly affects its optical performance; 3) It is difficult to control the drug loading and release rate of the device, so the effectiveness and safety of the drug cannot be guaranteed; 4) Intraocular lens The preparation of drug coatings has disadvantages such as complex preparation process, slow speed, low efficiency, less total coating, difficult control of coating quality, and difficulty in customizing the coating shape.
5) Adding photocatalytic substances or antibody coatings to the intraocular lens has a certain effect on inhibiting cell or bacterial proliferation, but its range of action is small, and the effect is greatly affected by the stability of the coating

Method used

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  • A drug-eluting intraocular lens with sustained-release function and its preparation method
  • A drug-eluting intraocular lens with sustained-release function and its preparation method
  • A drug-eluting intraocular lens with sustained-release function and its preparation method

Examples

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preparation example Construction

[0045] The preparation method provided by the invention is carried out sequentially according to the following steps:

[0046] 1) Prepare the intraocular lens according to the design plan, and use it after ultrasonic cleaning;

[0047] 2) Preparation of drug-eluting coating: dissolve the degradable polymer and drug powder in an organic solvent; in the obtained spray solution, the concentration of the degradable polymer is 0.1-10%, preferably 5%; the concentration of the drug is 0.01%- 5%, preferably 0.2%; stand-by;

[0048] 3) Preparation of drug-eluting intraocular lens:

[0049] (1) Block the optics of the intraocular lens in step 1), and the haptics of the intraocular lens are selected as the spraying area;

[0050] (2) Apply the solution prepared in step 2) to the haptics of the intraocular lens accurately by using an ultrasonic atomization spraying system to form a drug coating on the surface, while keeping the optical part of the intraocular lens smooth and transparent...

Embodiment 1

[0061] The intraocular lens in this embodiment is made of hydrophobic polyacrylate material, and the non-steroidal anti-inflammatory drug bromfenac sodium is used as the drug.

[0062] Bromfenac sodium is a non-steroidal anti-inflammatory drug commonly used in ophthalmology. It mainly exerts anti-inflammatory effect by inhibiting cyclooxygenase-2, and has low cytotoxicity. Brookshire et al. found that IOLs pretreated with bromfenic acid were more effective at inhibiting the development of posterior capsule opacities in laboratory dogs than IOLs pretreated with prednisolone acetate.

[0063] Concrete manufacturing method comprises the following steps:

[0064] Apply hydrophobic polyacrylate material as per figure 1 The planar planar haptic intraocular lens produced by the design shown has two wide and symmetrically arranged flat haptics about the optic, which can provide a sufficient drug-loading platform for the drug-eluting coating. The optical part is designed with one sph...

Embodiment 2

[0068] This example is made of hydrophobic polyacrylate material, and the difference from Example 1 is that the drug used is indomethacin.

[0069] Indomethacin is a hydrophobic drug, which has a higher drug-loading potential than bromfenac sodium in Example 1. Recent studies have shown that indomethacin can not only exert anti-inflammatory effects by inhibiting cyclooxygenase-2, but also inhibit cell proliferation by inducing autophagy.

[0070] The preparation method of the intraocular lens is the same as that in Example 1. The PLGA and indomethacin powders are dissolved in ethyl acetate solution, the PLGA concentration is 5%, the drug concentration is 0.5%, and the loop of the intraocular lens is set as the spraying area. The drug PLGA solution was precisely sprayed onto the intraocular lens loop by using an ultrasonic atomization spraying system. The drug loading amount of each intraocular lens indomethacin was 100 μg or 500 μg, sterilized with ethylene oxide and sealed and ...

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Abstract

The invention relates to an artificial lens and a preparation method thereof. The purpose is to provide a drug-eluting intraocular lens with slow-release function and its preparation method; the intraocular lens should be able to effectively prevent cataract after phacoemulsification without affecting the light transmission and stability of the intraocular lens. A variety of common complications, so as to ensure the recovery of postoperative visual quality and avoid unnecessary serious consequences. The technical solution is: a drug-eluting intraocular lens with slow-release function, including the optical part of the intraocular lens and several haptics located on the edge of the optical part; A drug-eluting coating is attached to the surface of each loop, and the surface area of ​​the drug-eluting coating of each loop is more than 30% of the surface area of ​​the optical part.

Description

technical field [0001] The invention relates to an intraocular lens and a preparation method thereof, in particular to a foldable intraocular lens capable of replacing the intraocular lens in cataract phacoemulsification with drug sustained release function and a preparation method thereof, which can effectively inhibit microbial infection after cataract surgery , inflammatory response, and postoperative complications such as posterior capsule opacity. Background technique [0002] Cataract is still the leading cause of blindness worldwide. According to the report of the World Health Organization, there are about 285 million visually impaired people in the world, of which about 94 million are caused by cataract. As the population ages, the incidence and number of cataracts will continue to increase. Phacoemulsification is the only effective way to treat cataract at present. However, there are still some postoperative complications in modern cataract surgery, such as endopht...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F9/007A61M31/00A61F2/16
CPCA61F9/00736A61M31/002A61F2/16A61F2/1601A61M2210/0612A61M2210/005
Inventor 韩海杰姚克计剑张晓波汪璟
Owner ZHEJIANG UNIV
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