A kind of natural active ingredient anti-inflammatory repair essence and preparation method thereof
A technology of active ingredients and essence, applied in the field of anti-inflammatory essence of natural active ingredients and preparation thereof, can solve the problems of unsatisfactory skin absorption efficiency, safety and controllability of anti-inflammatory effect, high molecular weight, and achieve stability Efficacy and quality control, good biocompatibility, good anti-inflammatory effect
Active Publication Date: 2022-01-04
OCEAN UNIV OF CHINA
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Problems solved by technology
However, polysaccharides are polymers with high molecular weight and mostly heteropolymeric structures, and the active ingredients are not single, so the controllability of their skin absorption efficiency, safety and anti-inflammatory effects is still not ideal
Method used
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Embodiment
[0043] A natural active ingredient anti-inflammatory essence, its ingredients are calculated in parts by weight, 2 parts of D-galactose-4-sulfate freeze-dried powder, 0.1 part of carbomer, 0.02 part of alginate, 0.05 part of hyaluronic acid, 12 parts of glycerin, 0.05 part of lavender essential oil as essence, and deionized water make up to 100 parts.
[0044] The preparation method is that all the components are stirred evenly, and then sterilized to obtain the essence.
[0045] Wherein, the preparation method of D-galactose-4-sulfate is:
[0046] First, it is the preparation of agar. Using Porphyra variegata produced in Shandong as raw material, crush the dried Porphyra variegata through a grinder, pass through a 60-mesh sieve, accurately weigh 15g of laver powder into a 1L beaker, add 300mL of 95% ethanol, and stir at 40°C for 2 hours to remove Fat-soluble small molecular impurities such as polyphenols and pigments. Add 450 mL of pure water to the degreased laver powder ...
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The invention provides an anti-inflammatory and repairing essence with natural active ingredients, which is characterized in that it contains D-galactose-4-sulfate. The specific preparation method is as follows: first extract and prepare D-galactose-4-sulfate freeze-dried powder from Porphyra variegata; then take D-galactose-4-sulfate 0. 5~ 10. Carbomer 0.05~0.15, alginate 0.01~0.02, hyaluronic acid 0.01~0.1, glycerin 6~12, essence 0.01~0.1, deionized water to make up to 100, stir evenly and then sterilize to obtain essence. The notable feature of the present invention is that the anti-inflammatory active ingredient with D-galactose-4-sulfate extracted from seaweed as the core is a single pure small molecule compound, which is easy to absorb, and also convenient to precisely design the formula, stabilize the efficacy and quality control. Animal experiments and human experiments prove that the essence provided by the solution of the present invention is helpful for the treatment and repair of skin inflammation damage such as acne, papules, and pustules.
Description
technical field [0001] The invention relates to the technical field of cosmetics, in particular to an anti-inflammatory essence with natural active ingredients and a preparation method thereof. Background technique [0002] A large number of skin problems are related to inflammation. For example, common acne is a chronic inflammatory skin disease of pilosebaceous glands, which is mainly related to factors such as excessive secretion of sebaceous glands, colonization and overgrowth of Propionibacterium acnes, and abnormal keratinization of pilosebaceous gland ducts. Propionibacterium acnes can directly regulate the differentiation of keratinocytes in the formation of acne, and establish a positive feedback by stimulating keratinocytes to produce pro-inflammatory cytokines IL-1, IL-8, TNF-α, etc. in the local inflammatory response. Sustain promotes inflammatory processes, affects the expression of metalloproteinases MMPs during scar repair. [0003] In addition, inflammation...
Claims
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IPC IPC(8): A61K8/81A61K8/73A61K8/60A61K8/34A61P17/00A61P17/10A61P29/00A61Q19/00
CPCA61K8/60A61K8/735A61K8/73A61K8/345A61K8/8147A61Q19/00A61P29/00A61P17/10A61P17/00A61K2800/84
Inventor 付晓婷陈晓丹宋文佳
Owner OCEAN UNIV OF CHINA