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Atomizing agent for treating chronic obstructive pulmonary disease and preparation and application thereof

A chronic obstructive pulmonary disease and aerosol technology, which is applied in nebulizers for treatment, aerosol delivery, and respiratory diseases. The effect of reducing cell tolerance and improving drug efficacy

Pending Publication Date: 2021-03-05
青海省监狱管理局中心医院 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although it can effectively alleviate the symptoms of some patients, it is difficult to suppress the progressive damage of chronic lung disease with western medicine treatment. After long-term use, it may cause a series of side effects, such as osteoporosis, fungal infection, etc.

Method used

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  • Atomizing agent for treating chronic obstructive pulmonary disease and preparation and application thereof
  • Atomizing agent for treating chronic obstructive pulmonary disease and preparation and application thereof
  • Atomizing agent for treating chronic obstructive pulmonary disease and preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0035] Preparation example 1: the preparation of atomizing agent is:

[0036] Weigh an appropriate amount of rhododendron, add 7 times the amount of medicinal materials and soak in distilled water for 1 hour, extract the volatile oil by steam distillation, collect the volatile oil, seal it and put it in the refrigerator for refrigeration. The extract was filtered, and the filtrate was concentrated to an appropriate amount, and set aside. Add gentian flower 100g, barberry bark 500g, corydalis dwarf 100g, horse urine bubble 10g, licorice 50g, fritillary fritillary 50g, crab shell 50g, egg ginseng 50g and Tibetan woody fragrance 80g nine herbs , add 7 times the amount of medicinal materials, soak in distilled water for 1 hour, reflux extraction twice, each time for 2 hours, combine the two extracts, filter, and concentrate the filtrate under reduced pressure to an appropriate amount, add the first extract concentrate of Rhododendron rhododendron, and continue to concentrate under...

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PUM

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Abstract

The invention provides an atomizing agent for treating the chronic obstructive pulmonary disease. The atomizing agent at least comprises at least one of choline, gentiopicroside, peimine, berberine and glycyrrhetinic acid. Research in the invention finds that active ingredients cooperate with each other, and the synergistic active ingredients are locally administrated in respiratory tracts and lungs through an atomization means, so that the effects of cleaning the airway, humidifying the airway, reducing infiltration of inflammatory cells, inhibiting release of interleukin and other cytokines,improving airway stenosis and remarkably improving the treatment effect can be achieved; moreover, the cell intolerance of local administration can be synergistically reduced; and the cytotoxicity can be remarkably reduced.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to an atomized medicine for chronic lung diseases. Background technique [0002] Chronic pulmonary diseases often include chronic obstructive pulmonary disease, bronchial asthma, bronchiectasis, pulmonary interstitial disease, etc., which are mostly caused by long-term respiratory inhalation of smoke or other harmful particles, especially for individuals with weakened innate respiratory system immunity, chronic Lung disease is more likely to occur. Among them, chronic obstructive pulmonary disease (COPD) is one of the diseases with the highest morbidity and mortality worldwide. COPD is a common respiratory disease characterized by incompletely reversible airflow limitation and progressive development. Diseases and frequently-occurring diseases are one of the main causes of death worldwide, and its incidence is increasing year by year. It is estimated that it may become the third ...

Claims

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Application Information

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IPC IPC(8): A61K9/72A61K9/12A61K31/14A61K31/4375A61K31/56A61K31/58A61K31/7048A61M11/00A61K36/8966A61P11/00A61P29/00
CPCA61K9/0078A61K31/14A61K31/7048A61K31/58A61K31/4375A61K31/56A61K36/515A61K36/45A61K36/484A61K36/66A61K36/8966A61K36/29A61K36/344A61K36/53A61K36/28A61K36/81A61K36/80A61M11/00A61P11/00A61P29/00A61K2300/00
Inventor 吴尚洁孙智娜李顺祥雷思李娟李城拉毛卓玛何秀琴
Owner 青海省监狱管理局中心医院
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