Novel NIR-II diagnosis and treatment integrated silicon-carbon nanoprobe and preparation method thereof

A nano-probe and carbon nano-technology, applied in the field of nano-biomedical material preparation, can solve problems such as difficulty in penetration, and achieve the effect of improving the degree of enrichment and improving the performance of imaging and treatment

Active Publication Date: 2021-03-09
SHANXI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Light is scattered and absorbed by inner biological tissues, including water, blood, fat and skin, making it difficult to penetrate

Method used

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  • Novel NIR-II diagnosis and treatment integrated silicon-carbon nanoprobe and preparation method thereof
  • Novel NIR-II diagnosis and treatment integrated silicon-carbon nanoprobe and preparation method thereof
  • Novel NIR-II diagnosis and treatment integrated silicon-carbon nanoprobe and preparation method thereof

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preparation example Construction

[0035] A method for preparing a novel NIR-II integrated silicon-carbon nanoprobe for diagnosis and treatment, comprising the following steps:

[0036] S1. According to the molar ratio of deionized water: template agent: aluminum source: sodium hydroxide: silicon source = 10.02~16.67: 1.15~1.91: 1.25~2.08: 0.12~0.20: 1.99~3.33; deionized water, template agent Mix with aluminum source to form a mixed solution, stir at room temperature for 30 minutes; add 2 mol / L sodium hydroxide solution to the mixed solution, and stir for 30 minutes; add silicon source to it under stirring, and stir for 2 hours to form a white gel mixed solution ;

[0037] S2. Move the white gel mixed solution prepared in S1 into a polytetrafluoroethylene container, then place it in a reaction kettle, seal it, and place the reaction kettle in a thermostat to heat it tightly, with a heating temperature of 170°C, constant temperature, heat preservation, static Crystallize for 60 hours to form a crystallized gel ...

Embodiment 1

[0046] Take 83.33g of sodium hydroxide and 1L of deionized water, add them into a beaker and mix them thoroughly, transfer the mixed solution to a volumetric flask, and prepare a sodium hydroxide solution with a concentration of 2moL / L for later use;

[0047] Take 8.333g of sodium hydroxide and 1L of deionized water, add them into a beaker and mix them thoroughly, transfer the mixed solution to a volumetric flask, and prepare a sodium hydroxide solution with a concentration of 0.2moL / L for later use;

[0048] Take 135mL of deionized water, 155mL of tetraethylammonium hydroxide, and 2.565mg of sodium metaaluminate into a beaker in order to fully mix, stir at room temperature for 30min, add 30mL of 2mol / L sodium hydroxide solution to the mixed solution, stir for 30min, and take Add 30 g of white carbon black into the above mixed solution under stirring, and stir for 2 hours to form a white gel mixed solution;

[0049] Move the white gel mixed solution into a polytetrafluoroethyl...

Embodiment 2

[0053] Take 83.33g of sodium hydroxide and 1L of deionized water, add them into a beaker and mix them thoroughly, transfer the mixed solution to a volumetric flask, and prepare a sodium hydroxide solution with a concentration of 2moL / L for later use;

[0054] Take 8.333g of sodium hydroxide and 1L of deionized water, add them into a beaker and mix them thoroughly, transfer the mixed solution to a volumetric flask, and prepare a sodium hydroxide solution with a concentration of 0.2moL / L for later use;

[0055] Take 80mL of deionized water, 100mL of tetraethylammonium hydroxide, and 1.54mg of sodium metaaluminate into a beaker in order to fully mix, stir at room temperature for 30min, add 18mL of 2mol / L sodium hydroxide solution to the mixed solution, stir for 30min, and take Add 20 g of white carbon black into the above mixed solution under stirring, and stir for 2 hours to form a white gel mixed solution;

[0056] Move the white gel mixed solution into a polytetrafluoroethylen...

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Abstract

The invention relates to the technical field of preparation of nano biomedical materials, and particularly relates to a novel NIR-II diagnosis and treatment integrated silicon-carbon nanoprobe and a preparation method thereof. According to the nanoprobe, a surfactant and white carbon black are used as a template agent and a silicon source, a Beta molecular sieve which is uniform in dispersion anduniform in particle size is synthesized, the Beta molecular sieve is used as a template to load ionic liquid, and the nanoprobe with NIR-II fluorescence/ NIR-II photoacoustic dual-mode imaging and NIR-II photothermal therapy is constructed through high-temperature carbonization and template etching.

Description

technical field [0001] The invention relates to the technical field of preparation of nano biomedical materials, and more specifically relates to a novel NIR-II integrated silicon-carbon nanoprobe for diagnosis and treatment and a preparation method thereof. Background technique [0002] Tumor is one of the important diseases that threaten human health, and realizing simultaneous diagnosis and treatment is one of the important means to overcome cancer. In recent years, with the development of bionanotechnology and nanomedicine, multifunctional nanomaterials with diagnostic and therapeutic functions have attracted extensive attention. With the rise of nanotechnology, using the characteristics of nanomaterials to combine the functions of targeted drug delivery, living body tracking, drug therapy and prognosis monitoring, the development of a safe, efficient and integrated nano-platform for diagnosis and treatment that meets specific needs has become a major issue in today's ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K49/22A61K49/00A61P35/00C01B33/021C01B32/15B82Y30/00B82Y40/00
CPCA61K41/0052A61K49/0002A61K49/22A61K49/0019A61P35/00C01B33/021C01B32/15B82Y30/00B82Y40/00
Inventor 郑子良张瑞平贾卓秦宇飞段艾林
Owner SHANXI MEDICAL UNIV
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