Optical clearing agent and preparation method thereof

A light-clearing agent and a transparent technology, which is applied in the field of light-clearing agent and its preparation, can solve the problems of inability to achieve tissue light-transparency, and the refractive index of the light-clearing agent cannot be arbitrarily adjusted as needed, and achieves a large penetration depth of light tissue. , the effect of reducing the degree of scattering and enhancing the depth of penetration

Inactive Publication Date: 2021-03-09
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is still a certain difference between the refractive index of these light clearing agents and the essence of the tissue, which cannot achieve optimal light transparency of the tissue, and the refractive index of the tissue in different parts is also slightly different, and the refractive index of these light clearing agents reported It cannot be adjusted arbitrarily as needed to be suitable for the phototransparency of different tissue parenchyma, so there are still huge challenges in r

Method used

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  • Optical clearing agent and preparation method thereof
  • Optical clearing agent and preparation method thereof
  • Optical clearing agent and preparation method thereof

Examples

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Embodiment 1

[0048] This embodiment provides a light transparent agent, including the first component and the second component; wherein:

[0049] The first component is composed of PEG400 and glycerol with a volume ratio of 0.73:1;

[0050] The second component is thioketone;

[0051] The volume ratio of the first component to the second component is 19:1.

[0052] This embodiment also provides the preparation method of the above-mentioned optical transparent agent, comprising the following steps:

[0053] (1) Add 1.1mL glycerin to 0.8mL PEG400, stir and mix well with a magnetic stirrer to obtain the first component;

[0054] (2) Put thione in a glass bottle, heat the oil bath to 45°C to melt thione, then use a pipette gun to draw 0.1mL of thione liquid into the first component, and use a magnetic stirrer to fully stir Mix well and serve.

Embodiment 2

[0056] This embodiment provides a light-transparent agent, the only difference from Example 1 is that the first component is composed of PEG400 and glycerin with a volume ratio of 3:2, and the first component and the second group The volume ratio of the points is 10:1.

Embodiment 3

[0058] This embodiment provides a light-transparent agent, the only difference from Example 1 is that the first component is composed of PEG400 and glycerin with a volume ratio of 11:8, and the first component and the second group The volume ratio of the points is 19:1.

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Abstract

The invention relates to the technical field of biological imaging, in particular to an optical clearing agent and a preparation method thereof. The optical clearing agent comprises a first componentand a second component, wherein the first component is composed of PEG400 and glycerol in the volume ratio of (0.2-5.0): 1; the second component is thiazone; and the volume ratio of the first component to the second component is (1-50): 1. The optical clearing agent obtained by selecting the specific components and compounding the components according to the specific ratio can reduce the scattering degree of tissues to light, and compared with other optical clearing agents in the prior art, the optical clearing agent provided by the invention has the advantage that the optical tissue penetration depth is larger.

Description

technical field [0001] The invention relates to the technical field of biological imaging, in particular to an optical transparent agent and a preparation method thereof. Background technique [0002] In recent years, with the development of optical devices, the medical application of light has become more and more mature, and has also spawned some new disciplines, such as biomedical photonics. At present, light has been widely used in the clinical diagnosis and treatment of diseases, including medical imaging (such as fluorescence imaging, up-conversion imaging, photothermal imaging, photoacoustic imaging, etc.), phototherapy (including photothermal therapy, photodynamic therapy, laser ablation, UV therapy, etc.) and optogenetics. In medical imaging, near-infrared light is used to excite indocyanine green (ICG) fluorescence imaging to observe its clearance in the human body in real time, so as to judge the liver reserve function of patients. In terms of photothermal thera...

Claims

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Application Information

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IPC IPC(8): A61K49/00A61K49/22A61K41/00A61P35/00G01N1/28G01N1/30
CPCA61K41/0042A61K41/0052A61K41/0057A61K49/00A61K49/0019A61K49/0021A61K49/22A61P35/00G01N1/28G01N1/30
Inventor 赵彦兵赵浩徐家宝杨祥良
Owner HUAZHONG UNIV OF SCI & TECH
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