radioactive glass microspheres

A glass microsphere, radioactive technology, applied in the field of biomedical materials, can solve the problems of radiation dose limitation, unable to achieve tumor radical cure dose, etc., and achieve the effect of high radiation energy

Active Publication Date: 2022-06-07
HEFEI BREATH MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Using external radiation therapy to treat malignant tumors, in consideration of avoiding damage to normal tissues near the irradiation site or causing systemic side effects, the radiation dose is greatly limited, and the dose of external radiation application often cannot reach the radical cure dose of the tumor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040]This embodiment provides a first radioactive glass microsphere group and a preparation method of each radioactive glass microsphere in the first radioactive glass microsphere group. The preparation method of each radioactive glass microsphere in the first radioactive glass microsphere group is as follows:

[0041] S11: Provide a well-mixed first inorganic mixture as a raw material, vacuum dry at 100° C. for 1-3 hours, and preheat to 1350° C.-1600° C. in a high-temperature box furnace to obtain a melt.

[0042] S12: Quenching the melt in water to obtain a frit, and then vacuum drying the frit at 100° C. for 24 hours to obtain a dry frit.

[0043] S13: Using a planetary ball mill to grind the dry frit into solid powder.

[0044] S14: Place the solid powder in a gas flame to re-melt to obtain a spheroidized melt.

[0045] S15: sequentially cooling and screening the spheroidized melt to obtain radioactive glass microspheres with an average particle size of 15-200 microns. ...

Embodiment 2

[0086] Embodiment 2 of the present invention provides a second radioactive glass microsphere group, and the preparation method of each radioactive glass microsphere in the second radioactive glass microsphere group is the same as that of the first radioactive glass microsphere group in Example 1. The difference in the preparation method of each radioactive glass microsphere is that the raw material for preparing the radioactive glass microsphere is the second inorganic mixture.

[0087] Each radioactive glass microsphere in the second inorganic mixture and the second radioactive glass microsphere group is composed of a molar percentage of 13-30% Y 2 O 3 , 40-60 mol% SiO 2 , 10-30 mol% MnO and 5-15 mol% ZrO 2 composition.

[0088] Table 6 of Example 2 of the present invention provides the molar percentage content of each component of 15 kinds of radioactive glass microspheres with glass sample numbers S201 to S215.

[0089] Table 6

[0090]

[0091] In Example 2 of the ...

Embodiment 3

[0097] Embodiment 3 of the present invention provides a third group of radioactive glass microspheres. The difference in the preparation method of each radioactive glass microsphere is that the raw material for preparing the radioactive glass microsphere is the third inorganic mixture.

[0098] Each radioactive glass microsphere in the third inorganic mixture and the third radioactive glass microsphere group is composed of a molar percentage of 13-30% Y 2 O 3 , 40-60 mol% SiO 2 , 10-30 mol% MnO and 5-15 mol% TaO 2 composition.

[0099] Table 8 of Example 3 of the present invention provides the molar percentage of each component of 15 kinds of radioactive glass microspheres with glass sample numbers S301 to S315.

[0100] Table 8

[0101]

[0102] In Example 3 of the present invention, the densities ρ of the 15 kinds of radioactive glass microspheres recorded in Table 8 were investigated according to the ASTM B923 test standard, and the axial CT scan was loosely placed ...

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Abstract

The invention provides a radioactive glass microsphere, which is composed of yttrium oxide with a molar percentage of 10-30%, silicon oxide with a molar percentage of 35-70%, and strontium carbonate with a molar percentage of 0-25%. Any one of manganese oxide and potassium oxide at 0-40 mole percent, praseodymium oxide at 0-25 mole percent, cesium oxide at 0-25 mole percent, 0-25 mole percent 25% zirconium oxide and 0-25% tantalum oxide by mole. The 10-30% yttrium oxide contained in the radioactive glass microspheres can release a certain dose of radioactive element yttrium-90 after being activated in vivo to provide higher radiation energy, and the radioactive microspheres have 2 ‑3.7 g / cm3 low density, composed of inorganic substances, non-shrinkable and radiopaque, which is conducive to smooth delivery to the tumor site in the body and uniform distribution in the tumor site, so as to facilitate the delivery process Visual guidance using CT scans, fluoroscopy, and X-ray imaging.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to radioactive glass microspheres. Background technique [0002] The use of external radiation therapy to treat malignant tumors takes into account the avoidance of damage to normal tissues near the irradiation site or causing systemic side effects. [0003] The radioactive microspheres are infused into the human body through local arteries, so that the radioactive nuclides are concentrated in the tumor area, so as to produce a radical irradiation effect on the tumor area. The damage is small, and it will not cause systemic side effects, so it has a good application prospect. [0004] The key to internal radiation therapy is to enable the radiopharmaceuticals to be uniformly distributed in the tumor to cover the entire tumor tissue, and to provide sufficient radiation energy to achieve the radical dose of the tumor, and requires full fluoroscopic guidance. [0005] Th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C03C12/00C03C4/00A61K51/12A61P35/00A61K103/32
CPCA61K51/1251A61P35/00A61K49/048
Inventor 张晓芳曹金象宋保组逄永刚冯福玲逄君瑶
Owner HEFEI BREATH MEDICAL CO LTD
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