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Application of equisetin in preparation of anti-arthritis drugs

A technology of imamycin and anti-arthritis, applied in the direction of anti-inflammatory agent, drug combination, drug delivery, etc., can solve the problem of undiscovered imamycin application, achieve good therapeutic effect, reduce content, and slow foot swelling Effect

Inactive Publication Date: 2021-03-19
GUANGXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application of izamicin in other diseases or related aspects has not been found so far

Method used

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  • Application of equisetin in preparation of anti-arthritis drugs
  • Application of equisetin in preparation of anti-arthritis drugs
  • Application of equisetin in preparation of anti-arthritis drugs

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Embodiment Construction

[0049]In order to make the invention, the technical solution, and its technical effects are more clear, the present invention will be described in further detail below. It should be understood that the specific embodiments described in this specification are merely intended to illustrate the invention, and is not intended to limit the invention.

[0050]Experimental materials and reagents used are consumables and reagents that are conventionally available from commercial pathways without specifically description.

[0051]Iramymycin drug effective amount test

[0052]The present embodiment determines the effective amount of Irai hypermycin drug by activation of NF-κB, which is:

[0053]When the inflammatory response occurs in the body, the natural immune response will be activated, and the natural immune response cells can release inflammatory factors (such as interleukin IL-1, IL-6, IL-8, active oxygen, cycloal oxygenase-2, oxidizing Nitrogenase and growth factor, etc.), the transcription of th...

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PUM

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Abstract

The invention discloses an application of equisetin in preparation of an anti-arthritis drug. The content of the equisetin is greater than or equal to 0.1 [mu] M. A transdermal absorption preparationprepared by taking the equisetin as a raw material has the characteristic of direct and remarkable inhibition effect on carrageenan-induced acute arthritis, is good in treatment effect, can be used for effectively relieving foot swelling of mice, and can be used for treating arthritis and other related diseases. Moreover, the preparation can also effectively inhibit the expression of inflammatoryfactors IL-1, IL-6 and TNF-alpha, reduce the content of inflammatory factors in serum and reduce inflammation. The preparation is externally and directly applied to an affected part, is convenient touse and has extremely high use value.

Description

Technical field[0001]The invention belongs to the field of pharmaceutical preparations, and specific applications of Iraiomycin in preparing anti-arthritisia drugs.Background technique[0002]Arthritis is a common chronic disease. The number of patients is more, and the incidence rate is 13%, and one person is sick every 10 people. Arthritis is an inflammatory disease caused by hinders and its surrounding tissues, caused by inflammation, infection, degradation, trauma or other factors, can be divided into osteogeneity, rheumatic, strong, reactivity, gout, Tens of rheumatism and purulentness. Arthritis is huge, and its disability rate can be as high as 53%, which is extremely harmful. The severity of arthritis causes pain and dysfunction, which can be quite even greater than cardiovascular and cerebrovascular disease, and there is currently no stable and effective anti-arthritic drug, which is currently used in the treatment of arthritis, there are still many problems, such as Poor sel...

Claims

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Application Information

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IPC IPC(8): A61K31/4015A61K9/00A61K47/06A61K47/10A61P19/02A61P29/00
CPCA61K9/0014A61K31/4015A61K47/06A61K47/10A61P19/02A61P29/00
Inventor 谭艳辉谭小辉李智超罗小卫黄文婧
Owner GUANGXI NORMAL UNIV
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