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Chitosan/Mxene antibacterial composite sponge for hemostasis and preparation method thereof

A technology of composite sponge and chitosan, applied in application, pharmaceutical formulation, surgical adhesive and other directions, can solve the problems of poor flexibility of hemostatic sponge, increase process complexity, and insignificant hemostatic effect, and is beneficial to large-scale industrial production. , Improve flexibility, expand the effect of application

Active Publication Date: 2021-03-19
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although chitosan has dual properties of hemostasis and antibacterial properties, a single non-alkaline chitosan hemostatic sponge has poor flexibility and is easy to collapse when exposed to water (Carbohyd. Polym., 2017, 174, 432-442), and the hemostatic effect is not significant. Weak healing ability, difficult to meet the requirements of war wound hemostasis and clinical rapid hemostasis
The alkalization treatment not only increases the complexity of the process, but also the residual alkali will stimulate the deterioration of the wound
In addition, the alkalization process may destroy the original structure of the sponge, which is not conducive to blood enrichment (RSC Adv., 2017, 7, 34655-34663)

Method used

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  • Chitosan/Mxene antibacterial composite sponge for hemostasis and preparation method thereof
  • Chitosan/Mxene antibacterial composite sponge for hemostasis and preparation method thereof
  • Chitosan/Mxene antibacterial composite sponge for hemostasis and preparation method thereof

Examples

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Effect test

Embodiment 1

[0032] The preparation of chitosan / Mxene antibacterial composite sponge for hemostasis, concrete steps are as follows:

[0033] (1) under stirring condition, join the chitosan that molecular weight is 100,000 to be dissolved in the acetic acid solution that volume percent concentration is 0.4%, obtain the chitosan acetic acid solution that chitosan concentration is 5g / L;

[0034] (2) Under stirring conditions, add N-(2-hydroxyethyl)acrylamide (the mass ratio of N-(2-hydroxyethyl)acrylamide to chitosan is 3:10) into chitosan-acetic acid solution and mix Uniformly, a mixed solution is obtained;

[0035] (3) Under stirring conditions, add Ti to the mixed solution 3 C 2 T x , mixed evenly to obtain 0.5g / L Ti 3 C 2 T x Chitosan / N-(2-hydroxyethyl)acrylamide / Ti 3 C 2 T x The mixed solution; the mixed solution is vacuum freeze-dried to obtain the chitosan / Mxene antibacterial composite sponge for hemostasis.

[0036] The chitosan / Mxene antibacterial composite sponge prepared ...

Embodiment 2

[0040] The preparation of chitosan / Mxene antibacterial composite sponge for hemostasis, concrete steps are as follows:

[0041] (1) under stirring condition, molecular weight is that 200,000 chitosans are joined in the acetic acid solution that volume percent concentration is 0.5%, obtain the chitosan acetic acid solution that chitosan concentration is 5g / L;

[0042] (2) Under stirring conditions, add N-(2-hydroxyethyl)acrylamide (mass ratio to chitosan is 1:2) into the chitosan acetic acid solution and mix evenly to obtain a mixed solution;

[0043] (3) Under stirring conditions, add Ti to the mixed solution 3 C 2 T x , mixed evenly to obtain 5g / LTi 3 C 2 T x Chitosan / N-(2-hydroxyethyl)acrylamide / Ti 3 C 2 T x The mixed solution; the mixed solution is vacuum freeze-dried to obtain the chitosan / Mxene antibacterial composite sponge for hemostasis.

[0044] The microscopic appearance data picture of the chitosan / Mxene antibacterial composite sponge prepared by embodiment 2...

Embodiment 3

[0048] The preparation of chitosan / Mxene antibacterial composite sponge for hemostasis, concrete steps are as follows:

[0049] (1) under stirring condition, adding molecular weight is that 250,000 chitosan is dissolved in the acetic acid solution that volume percentage concentration is 0.8%, obtains the chitosan solution that chitosan concentration is 5g / L;

[0050] (2) Under stirring conditions, add N-(2-hydroxyethyl)acrylamide (the mass ratio of N-(2-hydroxyethyl)acrylamide to chitosan is 1:1) into chitosan acetic acid solution and mix Uniformly, a mixed solution is obtained;

[0051] (3) Under stirring conditions, add Ti to the mixed solution 3 C 2 T x , mixed evenly to obtain 20g / LTi 3 C 2 T x Chitosan / N-(2-hydroxyethyl)acrylamide / Ti 3 C 2 T x The mixed solution; the mixed solution is vacuum freeze-dried to obtain the chitosan / Mxene antibacterial composite sponge for hemostasis.

[0052] The chitosan / Mxene antibacterial composite sponge prepared in Example 3 pre...

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Abstract

The invention discloses a chitosan / Mxene antibacterial composite sponge for hemostasis and a preparation method thereof. The method comprises the following step: carrying out vacuum freeze drying by taking chitosan as a raw material, N-(2-hydroxyethyl) acrylamide as a monomer and Ti3C2Tx as a reinforcing agent to prepare the chitosan / Mxene composite hemostatic sponge for hemostasis. The chitosan / Mxene composite sponge obtained by the invention solves the problem that the chitosan sponge collapses when touching water, has excellent flexibility, porosity and the capacity of rapidly absorb waterin a short time to expand, can rapidly absorb blood and generate physical compression on surrounding tissue to promote hemostasis and healing of a wound surface, can be used for rapid hemostasis and wound surface healing of various wound surfaces and lumens, and has relatively good clinical application prospects.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a chitosan / Mxene antibacterial composite sponge for hemostasis and a preparation method thereof. Background technique [0002] In recent years, uncontrolled bleeding is still the main cause of death of patients. In emergency treatment, hemostasis is the top priority. The survival rate of patients is largely related to whether bleeding can be effectively controlled. In order to better To control traumatic bleeding, researchers are constantly looking for and developing efficient and safe hemostatic materials. At present, there are many hemostatic materials available in the market, such as zeolite powder, Arista hemostatic microspheres, medical gelatin sponge, etc. Although they all have hemostatic function, there are still many deficiencies. [0003] Chitosan is a natural polycationic polysaccharide derived from partial deacetylation of chitin. Due to its good biocompatibilit...

Claims

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Application Information

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IPC IPC(8): A61L24/08A61L24/00A61L24/02
CPCA61L24/0078A61L24/0015A61L24/0036A61L2400/04A61L2300/102A61L2300/236A61L2300/404A61L2300/418C08L5/08Y02A50/30
Inventor 王小英吴正国唐淑玮
Owner SOUTH CHINA UNIV OF TECH
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