Method for continuous recrystallization of furan ammonium salt crude product

Abstract

The invention relates to the technical field of pharmaceutical intermediates, in particular to a method for continuous recrystallization of a furan ammonium salt crude product. The crude ammonium furan salt is dissolved, decolorized, and enters the temperature-controlled evaporator for evaporation and crystallization. The liquid level in the temperature-controlled evaporator is maintained constant by controlling the feed rate and output speed; crystallization, filtration, and drying to obtain furan ammonium salt, thereby realizing the continuous recrystallization of the furan ammonium salt crude product. By keeping the liquid level constant during the recrystallization process, the present invention effectively improves the heat utilization rate of the equipment, greatly reduces the generation of unqualified products hanging on the wall, maintains a balanced and stable state for recrystallization throughout the process, and improves the efficiency of distillation and the quality of products. The yield can effectively increase the heat utilization rate, reduce the amount of waste liquid, and reduce the cost of power.

Description

Method for continuous recrystallization of furan ammonium salt crude product technical field The present invention relates to pharmaceutical intermediate technical field, be specifically related to a kind of method for continuous recrystallization of furan ammonium salt crude product Law. Background technique [0002] Furan ammonium salt is a key intermediate for synthesizing the second-generation cephalosporin antibiotic cefuroxime. Cefuroxime is antibacterial Since it was launched in 1988, it has become the best-selling product in the world. one of the drugs. At present, the method for refining and recrystallization in the chemical industry production technique of furan ammonium salt is mainly vacuum distillation, by liter The crude furan ammonium salt was dissolved in methanol, activated carbon was added for decolorization to obtain a decolorizing solution, and methanol was distilled off under reduced pressure. Recrystallization is carried out to obtain a produ...

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Problems solved by technology

The product refining method is mainly based on the intermittent discharge method. In the second half of the product distillation, the distillation efficiency is greatly reduced with the enrichment of the water content, and the energy consumption increases. A large number of unqualified products are deposited on the wall, the product quality declines rapidly, the heat utilization rate is low and the time period is long, and the production efficiency is low