Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Theaflavin composition and application thereof

A technology of theaflavins and composition, which is applied in the application field of theaflavins, and can solve the problems that theaflavins are rarely seen

Active Publication Date: 2021-03-26
HUNAN AGRICULTURAL UNIV
View PDF2 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on theaflavins is mainly focused on the anti-oxidation effect, and there are few reports on the use of theaflavins in the fields of anti-ultraviolet and anti-inflammation. How to efficiently use theaflavins for the prevention of photoaging caused by ultraviolet rays , with significant significance

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Theaflavin composition and application thereof
  • Theaflavin composition and application thereof
  • Theaflavin composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A theaflavin composition comprising theaflavin-3'-gallate,

[0040] And, a skin care product carrier or a pharmaceutically acceptable carrier.

[0041] The concentration of theaflavin-3'-gallate (TF3'G, theaflavin-3'-gallate) is 0.1-40 μM.

[0042] The theaflavin composition is water, emulsion, ointment or cream.

[0043] The skin care product carrier includes a liquid carrier, excipient, reagent or a combination thereof.

[0044] The liquid carrier includes water, saline solution, aqueous dextrose solution, glycerol solution or combinations thereof.

[0045] Said excipients include starch, glucose, lactose, sucrose, gelatin, malt, rice, flour, chalk, silica gel, sodium stearate, glyceryl monostearate, talc, sodium chloride, skimmed milk powder, glycerin, propylene , ethylene glycol, ethanol or combinations thereof.

[0046] Such agents include wetting agents, stabilizers, emulsifiers, pH buffers, thickeners, lubricants, colorants or combinations thereof.

[0047] ...

Embodiment 2

[0092] A theaflavin composition of this embodiment, comprising theaflavin-3'-gallate and theaflavin, theaflavin-3-gallate or theaflavin-3,3'-gallate A mixture of 4 monomers,

[0093] And, a skin care product carrier or a pharmaceutically acceptable carrier.

[0094] The concentration of the theaflavin-3-gallate (TF3'G, theaflavin-3-gallate) is 0.5 μM, and theaflavin-3'-gallate and theaflavin, theaflavin-3- The mixture of gallate or theaflavin-3,3'-gallate four monomers accounts for 0.05%-2.0% by weight of the composition.

[0095] The theaflavin composition is water, emulsion, ointment or cream.

[0096] The skin care product carrier includes a liquid carrier, excipient, reagent or a combination thereof.

[0097] The liquid carrier includes water, saline solution, aqueous dextrose solution, glycerol solution or combinations thereof.

[0098] Said excipients include starch, glucose, lactose, sucrose, gelatin, malt, rice, flour, chalk, silica gel, sodium stearate, glyceryl m...

Embodiment 3

[0102] A theaflavin composition, comprising salts or derivatives, hydrates or solvates of theaflavin-3'-gallate available in the field of skin care products,

[0103] And, a skin care product carrier or a pharmaceutically acceptable carrier.

[0104] The concentration of the salt or derivative, hydrate or solvate of theaflavin-3-gallate (TF3'G, theaflavin-3'-gallate) is 0.25-20 μM, and theaflavin-3'-gallate The mass ratio of the acid ester salt or derivative, hydrate or solvate to the composition is 0.05%-2%.

[0105] The skin care product carrier or pharmaceutically acceptable carrier of the theaflavin composition in this embodiment is the same as that in Embodiment 1.

[0106] The application of a theaflavin composition of this embodiment is to use the theaflavin to prepare skin care products for the prevention of photoaging, specifically, to use the theaflavin to prepare skin photoaging caused by ultraviolet radiation. Aging skin care products, or using the theaflavins to...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A theaflavin composition comprising: theaflavin-3 '-gallate, or a separation mixture of theaflavin-3 '-gallate and one or more of theaflavin, theaflavin-3'-gallate or theaflavin-3, 3 '-gallate, or salt or derivative, hydrate or solvent compound of theaflavin-3 '-gallate capable of being obtained in the field of skin care products, and a skin care product carrier or a pharmaceutically acceptable carrier. The theaflavin composition can improve the activity of antioxidant enzyme, reduce the content of MDA and ROS, repair mitochondrial membrane potential to a certain extent and further reduce oxidative damage of UVB radiation to cells, thereby resisting photoaging damage of ultraviolet radiation to human skin. On the other hand, theaflavin-3'-gallate TF3 'G can effectively inhibit inflammatoryresponse caused by UVB radiation and reduce generation of HaCaT intracellular aggregates, and has a wide prospect in preparation of skin care products or drugs for preventing photoaging.

Description

technical field [0001] The invention relates to the field of application of theaflavin, in particular to a theaflavin composition and its application. Background technique [0002] Tea pigment is a kind of water-soluble pigment mixture derived from the oxidation of polyphenolic compounds mainly composed of catechins in tea, including theaflavins, thearubigins and theabrownins. Among them, theaflavins (Theaflavins, TFs) are the core functional components of black tea, which are called "soft gold" in tea. Theaflavins are a kind of benzotropenone structural compounds that are soluble in ethyl acetate, contain multiple phenolic hydroxyl groups, and are orange-yellow, produced by catechins through enzymatic reaction of phenylpropanoid cyclization. Important quality components and functional components of black tea, including theaflavin (theaflavin), theaflavin-3-gallate (theaflavin-3-gallate), theaflavin-3'-gallate (theaflavin-3'- gallate) and theaflavin-3,3′-digallate (theafla...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K8/49A61Q19/08A61Q17/04A61K31/353A61P17/16A61P17/18A61P29/00
CPCA61K8/498A61Q19/08A61Q17/04A61K31/353A61P17/16A61P17/18A61P29/00A61K2300/00
Inventor 蔡淑娴郑新冯美燕万娟潘雯婧谢昕雅胡宝珠石玉兰刘仲华王坤波王英姿文海涛李家峰
Owner HUNAN AGRICULTURAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com