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Method for distinguishing tetracycline and isomeride doxycycline thereof

An isomer, doxycycline technology, used in the analysis of materials, material analysis by electromagnetic means, measurement devices, etc.

Inactive Publication Date: 2021-03-26
ANHUI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the identification method for distinguishing the two has not been reported, so it is very necessary to find a qualitative analysis method with good distinguishing effect, simple and fast operation, and easy judgment of the results.

Method used

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  • Method for distinguishing tetracycline and isomeride doxycycline thereof
  • Method for distinguishing tetracycline and isomeride doxycycline thereof
  • Method for distinguishing tetracycline and isomeride doxycycline thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] The present embodiment verifies the feasibility of the method for distinguishing tetracycline and doxycycline of the present invention according to the following steps:

[0062] (1) Preparation solution

[0063] First prepare the sulfuric acid of 0.025mol / L with 98% concentrated sulfuric acid and distilled water as stock solution, then prepare respectively the potassium iodate solution of 0.14mol / L, the [NiL] of 0.0173mol / L with the sulfuric acid solution of 0.025mol / L ( ClO 4 ) 2 Solution, 2mol / L malonic acid solution, 4mol / L hydrogen peroxide solution. Add 14.7mL 0.025mol / L sulfuric acid solution, 5.3mL 0.14mol / L potassium iodate solution, 2.0mL 0.0173mol / L [NiL](ClO 4 ) 2 solution, 3mL 2mol / L malonic acid solution and 15.0mL 4mol / L hydrogen peroxide solution to ensure that "H 2 SO 4 - KIO 3 - [NiL](ClO 4 ) 2 - Malonic acid - H 2 o 2 The concentration of each component in the chemical oscillation system is sulfuric acid 0.025mol / L, potassium iodate 0.01855m...

Embodiment 2

[0073] The present embodiment verifies the feasibility of the method for distinguishing tetracycline and doxycycline of the present invention according to the following steps:

[0074] (1) Preparation solution

[0075] First prepare 0.025mol / L sulfuric acid with 98% concentrated sulfuric acid as a stock solution, then use 0.025mol / L sulfuric acid solution to prepare 0.14mol / L potassium iodate solution and 0.0173mol / L [NiL](ClO 4 ) 2 solution, 2mol / L malonic acid solution, 4mol / L hydrogen peroxide solution; add 15.0mL 0.025mol / L sulfuric acid solution, 5.3mL 0.14mol / L potassium iodate solution, 2mL 0.0173mol / L [NiL](ClO 4 ) 2 solution, 2.7mL 2mol / L malonic acid solution, 15mL 4mol / L hydrogen peroxide solution, to ensure that "H 2 SO 4 - KIO 3 - [NiL](ClO 4 ) 2 - Malonic acid - H 2 o 2 The concentration of each component in the chemical oscillation system is sulfuric acid 0.025mol / L, potassium iodate 0.01855mol / L, [NiL](ClO 4 ) 2 8.65×10 -4 mol / L, malonic acid 0.135m...

Embodiment 3

[0085] The present embodiment verifies the feasibility of the method for distinguishing tetracycline and doxycycline of the present invention according to the following steps:

[0086] (1) Preparation solution

[0087] First prepare the sulfuric acid of 0.025mol / L with 98% concentrated sulfuric acid and distilled water as stock solution, then prepare respectively the potassium iodate solution of 0.14mol / L, the [NiL] of 0.0173mol / L with the sulfuric acid solution of 0.025mol / L ( ClO 4 ) 2 Solution, 2mol / L malonic acid solution, 4mol / L hydrogen peroxide solution. Add 15mL of 0.025mol / L sulfuric acid solution, 5mL of 0.14mol / L potassium iodate solution, 1.8mL of 0.0173mol / L [NiL](ClO 4 ) 2 solution, 3.0mL 2mol / L malonic acid solution and 15.2mL 4mol / L hydrogen peroxide solution to ensure that "H 2 SO 4 - KIO 3 - [NiL](ClO 4 ) 2 - Malonic acid - H 2 o 2 The concentration of each component in the chemical oscillation system is sulfuric acid 0.025mol / L, potassium iodate 0...

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Abstract

A method for distinguishing tetracycline and isomeride doxycycline thereof is characterized in that an H2SO4-KIO3-[NiL](ClO4)2-malonic acid-H2O2 chemical oscillation system is used as a distinguishingsolution, and according to different influences of tetracycline and doxycycline on oscillation of the system, distinguishing of tetracycline and doxycycline is achieved. The potential oscillation spectrum provided by the distinguishing method has intuitiveness, tetracycline and doxycycline can be conveniently and quickly distinguished, and the distinguishing method is simple in equipment, high inaccuracy and easy to operate and observe.

Description

technical field [0001] The present invention relates to a kind of distinguishing method, specifically utilize a kind of nickel complex [NiL](ClO 4 ) 2 Method for distinguishing tetracycline isomer tetracycline and doxycycline by chemical oscillation system of catalysis, ligand L is 5, 7, 7, 12, 14, 14-hexamethyl-1, 4, 8, 11-Tetraazacyclotetradeca-4, 11-diene belongs to the field of qualitative analytical chemistry. Background technique [0002] Tetracycline and doxycycline are isomers of tetracycline antibiotics, each playing a pivotal role in their respective fields. Tetracycline, molecular formula: C 22 h 24 N 2 o 8 , Tetracycline can be used as a bacteriostatic agent, clinically used for bacillary dysentery, trachoma, pertussis, pneumonia, suppurative meningitis, skin infection, otitis media, etc. Doxycycline, molecular formula: C 22 h 24 N 2 o 8 , Doxycycline is an antibiotic drug, tetracycline drug, mainly used to treat respiratory tract, urinary tract and bi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/416
CPCG01N27/416
Inventor 胡刚陈卓周彦珂
Owner ANHUI UNIVERSITY
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