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Injectable hydrogel system and preparation method thereof

A hydrogel and system technology, applied in the field of injectable hydrogel system and its preparation, can solve the problems of expensive treatment, unstable curative effect, and long time consumption

Active Publication Date: 2021-03-30
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the common methods for treating meibomian gland dysfunction are divided into drug therapy and physical therapy. Drug therapy includes topical azithromycin smearing, anti-inflammatory eye drops, etc. Physical therapy includes eyelid margin cleaning and hot compress, intense pulse laser, etc. The curative effect of these methods Unstable, time-consuming and expensive to treat

Method used

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  • Injectable hydrogel system and preparation method thereof
  • Injectable hydrogel system and preparation method thereof
  • Injectable hydrogel system and preparation method thereof

Examples

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Effect test

Embodiment 1

[0043] Such as figure 1 with figure 2 As shown, weigh 1g of TG-18 and 100mg of rosiglitazone and add them to the solvent to obtain a mixed solution. The volume of the solvent is 10mL, and the volume ratio of DMSO to water in the solvent is 1:4, and then the mixed solution is heated Keep at 65°C for 15 minutes until TG-18 is completely dissolved, and then when the temperature is lowered to room temperature, an injectable hydrogel system will form after 10 minutes.

[0044] In the present embodiment, TG-18 is amphiphile triglyceride monostearate

Embodiment 2

[0046] Such as image 3Shown, the material properties of rosiglitazone hydrogel. Specifically, a, b: prepare blank TG-18 hydrogel and rosiglitazone hydrogel (the preparation process is the same as above), after vacuum freeze drying, the sample is gold-plated and photographed with a scanning electron microscope, and the blank can be observed The TG-18 hydrogel showed a lamellar structure, while the encapsulated rosiglitazone drug showed a fibrous structure in it. c, d: Rheological testing of TG-18 hydrogel and rosiglitazone hydrogel, it is found that when the temperature drops from 65 °C, the elastic modulus G' increases rapidly, and the formation of TG-18 hydrogel The gel temperature was 58.21°C and the rosiglitazone hydrogel was 60.78°C. e: As the shear rate increased, the viscosity of TG-18 hydrogel and rosiglitazone hydrogel decreased significantly, which indicated that both gels had shear-thinning behavior and were suitable for injection (shear rate From 0.1 to 100w / rad...

Embodiment 3

[0049] Such as Figure 4 As shown, specifically a, b: take the eyelid tissue of C57 / B6J mice, use micro scissors to remove the skin, subcutaneous tissue and conjunctiva of the eyelids under a microscope, and obtain simple mouse meibomian glands, and then use collagenase and Dispase The primary meibomian gland epithelial cells of mice were cultured after enzymatic digestion and inoculated on culture dishes; the meibomian gland epithelial cells were co-cultured with TG-18 hydrogel and rosiglitazone hydrogel for 2 days, and then stained with life and death Kit, the cells were stained for life and death and photographed. Green fluorescence showed live cells, and red fluorescence showed dead cells. It was found that neither rosiglitazone hydrogel nor TG-18 hydrogel could induce meibomian gland epithelial Cell death; c: The eyelid tissues of the experimental mice in each group were obtained and stained with HE. The staining observation found that there was no obvious inflammatory ce...

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Abstract

The invention relates to the technical field of hydrogel, and particularly provides an injectable hydrogel system which takes injectable hydrogel as a continuous substrate phase, rosiglitazone is distributed in the continuous substrate phase, and the injectable hydrogel is obtained by self-assembling amphiphilic triglyceride monostearate in a solvent. The invention provides a preparation method ofthe injectable hydrogel system. The method comprises the following steps: heating a mixed solution containing rosiglitazone and amphiphilic triglyceride monostearate, and standing and cooling to obtain the injectable hydrogel system. The invention provides an application of the injectable hydrogel system in preparation of a product for treating meibomian gland dysfunction. The injectable hydrogelsystem prepared by the method has feasibility and high efficiency in prevention and treatment of age-related meibomian gland dysfunction.

Description

technical field [0001] The invention relates to the field of hydrogel technology, in particular to an injectable hydrogel system and a preparation method thereof. Background technique [0002] Meibomian gland dysfunction (MGD) is "chronic diffuse abnormality of the meibomian glands, usually characterized by obstruction of distal ducts and / or qualitative / quantitative changes in glandular secretions. It may result in changes in the tear film , eye irritation symptoms, clinically significant inflammation and ocular surface disease. At the same time, meibomian gland dysfunction is the main cause of dry eye disease, according to a 2001 epidemiological study, more than 20 million people in the United States suffer from MGD. At present, the common methods for treating meibomian gland dysfunction are divided into drug therapy and physical therapy. Drug therapy includes local azithromycin smearing, anti-inflammatory eye drops, etc. Physical therapy includes eyelid margin cleaning and...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K47/14A61K31/4439A61P27/02
CPCA61K9/06A61K9/0019A61K47/14A61K31/4439A61P27/02
Inventor 傅瑶陈良波庞燕严丹
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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