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Anisotropic wound dressing and preparation method thereof

An anisotropic, wound-surface technology, applied in pharmaceutical formulations, pharmaceutical sciences, absorbent pads, etc., to achieve the effects of controllable size, simple preparation method and low cost

Active Publication Date: 2021-03-30
NANJING DRUM TOWER HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, it is necessary to change the dressing many times to keep the wound in a relatively dry environment, which brings great pain to the patient.

Method used

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  • Anisotropic wound dressing and preparation method thereof
  • Anisotropic wound dressing and preparation method thereof

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preparation example Construction

[0027] The invention provides a kind of preparation method of anisotropic wound dressing, comprises the following steps:

[0028] S1. Mix and stir the dopamine solution, nanoparticle solution, Tris base and hydrochloric acid for 6 hours under light-shielding conditions, so that the surface of the polydopamine-wrapped nanoparticle is obtained to obtain a polydopamine-wrapped nanoparticle solution, and the polydopamine-wrapped nanoparticle The diameter is 200nm; the nanoparticles are selected from silica nanoparticles or titania nanoparticles;

[0029] S2, adding the solution prepared in S1 to ethanol, so that the polydopamine-wrapped nanoparticles are uniformly dispersed in ethanol;

[0030] S3. Use a spray gun to spray the liquid obtained in S2 on the surface of the dressing for 3-5 times to ensure uniform coating. After the ethanol volatilizes, put the dressing with the sprayed side up and place it in the cultured place together with the dichloromethane solution of fluorosila...

Embodiment 1

[0034] Preparation of anisotropic wound dressing:

[0035] (1) Superhydrophobic treatment:

[0036] Mix 1.5 mL of dopamine solution (13.3 mg / mL), 2.03 mL of silica nano-solution (0.1 g / mL), 5 mL of Tris base (0.1 mol / L) and 1.47 mL of HCl (0.1 mol / L) into a glass bottle Stir in medium for 6 hours, so that polydopamine wraps the surface of silica nanoparticles. The obtained polydopamine-wrapped silica nanoparticles are evenly dispersed in ethanol, and sprayed repeatedly on the surface of polyurethane sponge with a spray gun for 3-5 times. Place them together in a petri dish, seal them with a parafilm, place them in an oven at 70 degrees Celsius, and the evaporation process lasts for 12 hours. like figure 1 As shown, a superhydrophobic surface is obtained.

[0037] (2) Super hydrophilic treatment:

[0038] In the case of protecting the superhydrophobic surface prepared in step (1), the rest of the dressing was treated with oxygen plasma for 15 minutes to make it superhydrop...

Embodiment 2

[0040] Preparation of anisotropic wound dressing:

[0041] (1) Superhydrophobic treatment:

[0042] Mix 1.5 mL of dopamine solution (13.3 mg / mL), 2.03 mL of silica nano-solution (0.1 g / mL), 5 mL of Tris base (0.1 mol / L) and 1.47 mL of HCl (0.1 mol / L) into a glass bottle Stir in medium for 6 hours, so that polydopamine wraps the surface of silica nanoparticles. Evenly disperse the obtained nanoparticles in ethanol, and use a spray gun to spray repeatedly on the surface of the chitosan sponge for 3-5 times. After the ethanol volatilizes, place the sprayed side upwards and place it on a petri dish together with the dichloromethane solution of fluorosilane , sealed with a parafilm, placed in an oven at 70 degrees Celsius, and the evaporation process lasted for 12 hours to obtain a superhydrophobic surface.

[0043] (2) Super hydrophilic treatment:

[0044] In the case of protecting the superhydrophobic surface prepared in step (1), the rest of the dressing was treated with oxyg...

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Abstract

The invention provides a preparation method of an anisotropic wound dressing. The method comprises the following steps: on the basis of a common hydrophilic dressing, modifying the dressing twice, carrying out super-hydrophobic treatment on the surface of one side of the dressing, and carrying out super-hydrophilic treatment on the rest part to obtain an anisotropic composite dressing; due to thedifference of surface tension between two parts with different wettability, the anisotropic wound dressing can realize directional delivery of wound exudate, solves the problem that a common hydrophilic dressing cannot keep the wound dry, reduces the infection risk, and promotes wound healing; the invention further provides the anisotropic wound dressing prepared according to the method. The preparation method is reasonable in design, simple and rapid, low in cost and high in experimental repeatability, and the prepared dressing is uniform in structure and controllable in shape and size and has important application value in the field of medical drainage.

Description

technical field [0001] The invention belongs to the technical field of biological materials, and in particular relates to an anisotropic wound dressing and a preparation method thereof. Background technique [0002] The treatment of excess exudate in the process of wound healing has gradually attracted attention, because it is easy to cause wound infection and hinder wound healing. Currently, various dressings have been used clinically to absorb excess exudate. However, whether it is traditional dressings such as gauze and cotton, or newly developed dressings such as hydrogel dressings and polyurethane sponges, in order to achieve better absorption effects, they often exhibit hydrophilic properties. After absorbing fluid, the interface between the dressing and the wound is often over-wet. Therefore, it is necessary to change the dressing many times to keep the environment of the wound relatively dry, which brings great misery to the patient. Therefore, it is necessary to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/26A61L15/28A61L15/40A61L15/18A61L15/42
CPCA61L15/26A61L15/28A61L15/40A61L15/18A61L15/42A61L2300/624C08L79/04
Inventor 赵远锦张涵王月桐王健张大淦
Owner NANJING DRUM TOWER HOSPITAL
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