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Hydrogel, preparation method thereof and medical equipment

A hydrogel and solution technology, used in medical science, prosthesis, tissue regeneration, etc.

Active Publication Date: 2021-04-02
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the repair effect of these materials currently used for tissue damage repair needs to be further improved

Method used

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  • Hydrogel, preparation method thereof and medical equipment
  • Hydrogel, preparation method thereof and medical equipment
  • Hydrogel, preparation method thereof and medical equipment

Examples

Experimental program
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Effect test

preparation example Construction

[0052] The preparation method of the above-mentioned hydrogel is simple and convenient, and the prepared hydrogel can significantly inhibit regeneration cells and tissue aging, and can improve the repair effect of tissue damage.

[0053] An embodiment of the present invention also provides a medical device, which can be used for tissue repair, such as cartilage repair, and the medical device includes the above-mentioned hydrogel.

[0054] In one of the embodiments, the medical device includes a storage chamber for storing the hydrogel and an extruding part, and the extruding part is used to extrude the hydrogel in the storage chamber. When in use, the above-mentioned hydrogel in the storage cavity is squeezed out and used on the tissue that needs to be repaired.

[0055] In another embodiment, the above-mentioned medical device includes a stent and the above-mentioned hydrogel, and the above-mentioned hydrogel is located on the stent. Optionally, the stent is a degradable ste...

Embodiment 1

[0061] The hydrogel of Example 1 includes strontium alginate and metformin hydrochloride, and its preparation method includes but not limited to the following steps:

[0062] (1) Dissolve 3g of sodium alginate (weight-average molecular weight of 86kDa) in 150mL of ultrapure water, stir with a magnetic stirrer at a rate of 300rpm until completely dissolved, and obtain alginic acid with a concentration of 20g / L of sodium alginate Sodium solution, namely 2% (m / v) sodium alginate solution.

[0063] (2) According to the final concentration of metformin being 1 mM, the metformin hydrochloride aqueous solution was dropped into the sodium alginate solution prepared in step (1) and fully stirred to prepare a mixture.

[0064] (3) Put 5 g of strontium chloride in a petri dish with a diameter of 10 cm, add 100 mL of ultrapure water, stir well to dissolve it completely, and prepare a 5% (m / v) strontium salt solution.

[0065] (4) Use a Pasteur pipette to absorb the mixture prepared in st...

Embodiment 2

[0068] The hydrogel of embodiment 2 is strontium alginate hydrogel, does not contain metformin and metformin salt, the preparation method of the hydrogel of embodiment 2 is roughly the same as the preparation method of the hydrogel of embodiment 1, and its difference is, The preparation method of the hydrogel in Example 2 omits step (2), that is, omits the step of adding metformin salt to the sodium alginate solution.

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Abstract

The invention relates to hydrogel, a preparation method thereof and medical equipment. The hydrogel comprises a first component and a second component, wherein the first component is selected from atleast one of metformin and metformin salt, and the second component is strontium alginate. The hydrogel has a good repairing effect when being used for repairing tissue damage.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a hydrogel, a preparation method thereof, and a medical device. Background technique [0002] Tissue damage is a clinically difficult problem, among which tissue damage in the motor system is particularly common, for example, cartilage damage. Due to the special structure of cartilage tissue, there are no nerves, blood vessels and lymphatic vessels in it. Although juvenile articular cartilage can obtain part of nutrition through the subchondral pathway, adult articular cartilage does not have subchondral nutrition pathway, and the nutrition supply of cartilage is through the pressure changes generated by joint activities, so that the synovial fluid flows between the joint cavity and the cartilage matrix, so Cartilage itself lacks effective repair ability, and cartilage damage often occurs at the same time as soft tissue damage around the joint, which is more serious than si...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/52A61L27/54
CPCA61L27/20A61L27/54A61L27/52A61L2300/206A61L2300/41A61L2300/40A61L2300/404A61L2430/34C08L5/04
Inventor 唐斌徐镭覃承诃马粉波
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA