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Preparation method of magnesium oxide/hydroxyapatite porous composite material

A technology of porous composite material and hydroxyapatite, which is applied in the field of biomedical material preparation, can solve problems such as inducing inflammation and gas generation, and achieves the effects of convenient operation, simple process, slow and long-term release

Pending Publication Date: 2021-04-02
KUNMING UNIV OF SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The template (porous material) is prepared in advance by using organic foam, and then prepared by squeeze casting. Although this method can accurately design the shape and size of the hole, it does not prepare the coexistence of large and small holes and a through-hole structure; and magnesium or magnesium alloy Easy to degrade rapidly in the body fluid environment, produce gas, induce inflammation, etc.

Method used

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  • Preparation method of magnesium oxide/hydroxyapatite porous composite material
  • Preparation method of magnesium oxide/hydroxyapatite porous composite material
  • Preparation method of magnesium oxide/hydroxyapatite porous composite material

Examples

Experimental program
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Effect test

Embodiment 1

[0033] A preparation method of magnesium oxide / hydroxyapatite porous composite material, specifically comprising the following steps:

[0034] (1) With purity ≥ 99.9%, nano-magnesia with particle size 100-200nm and purity ≥ 99.9%, nano-hydroxyapatite with particle size 150-300nm as raw materials, the mass percentage of magnesia powder in the mixed powder is 1 %, the mass percentage of hydroxyapatite is 99%.

[0035] (2) Put the powder weighed in step (1) into an agate ball mill jar, and put in an appropriate amount of agate balls (the ratio of agate balls and raw materials is 4:1, wherein the mass ratio of agate balls is large ball: medium ball: small ball = 1:4:5), and add an appropriate amount of absolute ethanol and dispersant (Span 80, the amount added is 0.3% of the original powder mass); ball mill at a speed of 300r / min for 8h; after ball milling, dry (drying temperature is 35 ℃), grinding.

[0036] (3) Pour the slurry obtained in step (1) into a petri dish, put the pe...

Embodiment 2

[0040] A preparation method of magnesium oxide / hydroxyapatite porous composite material, specifically comprising the following steps:

[0041](1) With purity ≥ 99.9%, nano-magnesia with particle size 100-200nm and purity ≥ 99.9%, nano-hydroxyapatite with particle size 150-300nm as raw materials, the mass percentage of magnesia powder in the mixed powder is 3 %, the mass percentage of hydroxyapatite is 97%.

[0042] (2) Put the powder weighed in step (1) into an agate ball mill jar, and put in an appropriate amount of agate balls (the ratio of agate balls and raw materials is 3:1, wherein the mass ratio of agate balls is large ball: medium ball: small ball = 1:7:9), and add an appropriate amount of absolute ethanol and dispersant (Span 80, the amount added is 0.5% of the original powder mass); ball mill at a speed of 300r / min for 8h. After ball milling, drying (drying temperature is 35° C.) and grinding are carried out.

[0043] (3) Pour the slurry obtained in step (1) into a...

Embodiment 3

[0047] A preparation method of magnesium oxide / hydroxyapatite porous composite material, specifically comprising the following steps:

[0048] (1) With purity ≥ 99.9%, nano-magnesia with particle size 100-200nm and purity ≥ 99.9%, nano-hydroxyapatite with particle size 150-300nm as raw materials, the mass percentage of magnesia powder in the mixed powder is 5 %, the mass percentage of hydroxyapatite is 95%.

[0049] (2) Put the powder weighed in step (1) into an agate ball mill jar, and put in an appropriate amount of agate balls (the ratio of agate balls and raw materials is 4:1, wherein the mass ratio of agate balls is large ball: medium ball: small ball = 1:6:7), and add an appropriate amount of absolute ethanol and dispersant (Span 80, the amount added is 0.4% of the original powder mass); ball mill at a speed of 400r / min for 10h; after ball milling, dry (drying temperature is 35 ℃), grinding.

[0050] (3) Pour the slurry obtained in step (1) into a petri dish, put the p...

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Abstract

The invention discloses a preparation method of a magnesium oxide / hydroxyapatite porous composite material, and belongs to the technical field of biomedical materials. The method comprises the following steps: by taking nano magnesium oxide powder and nano hydroxyapatite powder as raw materials, proportioning the magnesium oxide powder and hydroxyapatite according to the mass percent of (1-10%): (99-90%), weighing, ball-milling, drying and grinding to obtain composite powder; mixing the composite powder with medical-grade ammonium bicarbonate according to a volume percentage ratio of (40-80%):(60-20%), uniformly mixing, and pressing to obtain a long-strip-shaped green body; and preparing the magnesium oxide / hydroxyapatite porous composite material by spark plasma sintering. The porosity of the prepared composite material is 20%-60%, the pore size is 100-500 [mu] m and is controllable, and the composite material meeting various different requirements, such as bone scaffolds, bone filling and repair materials of hard tissue defect parts, can be prepared according to actual requirements.

Description

technical field [0001] The invention relates to a preparation method of a magnesium oxide / hydroxyapatite porous composite material, which belongs to the preparation technology in the field of biomedical materials. Background technique [0002] Biomedical composite materials refer to biomedical materials composed of two or more different biomedical materials, which are mainly used for the repair and replacement of human tissue and the manufacture of artificial organs. There are many natural composite materials in nature and human tissues, such as human bone, which is a fiber-reinforced composite material composed of collagen, protein and inorganic substances. The traditional single type of biomedical materials can meet the needs of biomedicine in some aspects, but it can not meet the standards in other aspects, and even produce adverse effects, which cannot meet the clinical application. Biomedical materials made of materials with different properties not only have the prope...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B35/447C04B35/64C04B38/02
CPCC04B35/447C04B35/64C04B38/02C04B2235/3206C04B2235/6562C04B2235/6581C04B2235/6567C04B2235/442C04B2235/96C04B38/0074C04B38/0054
Inventor 张玉勤黄文洁孟增东罗丽琳朱斌
Owner KUNMING UNIV OF SCI & TECH