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Preparation method of zinc oxide-magnesium oxide/hydroxyapatite porous composite material

A technology of porous composite materials and hydroxyapatite, which is applied in the field of biomedical materials, can solve the problems of impure composite materials, narrow safety range, and induced inflammation, and achieve the effects of avoiding cell toxicity, convenient operation, and simple process

Pending Publication Date: 2021-04-06
FIRST PEOPLES HOSPITAL OF YUNNAN PROVINCE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Hydroxyapatite is used as the additive phase, and zinc-magnesium alloy is used as the matrix. Zinc is a metal element with a narrow safety range. After implantation, zinc ions are released quickly, causing cell toxicity, and zinc-magnesium alloys are prone to gas-induced induction in body fluids. Inflammation; using NaCl as a pore-forming agent, it is easy to react with HA to generate Ca during the sintering process 5 (PO 4 ) 3 Compounds such as Cl, resulting in impurity of the composition of the composite material

Method used

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  • Preparation method of zinc oxide-magnesium oxide/hydroxyapatite porous composite material
  • Preparation method of zinc oxide-magnesium oxide/hydroxyapatite porous composite material
  • Preparation method of zinc oxide-magnesium oxide/hydroxyapatite porous composite material

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Embodiment 1

[0032] A preparation method of zinc oxide-magnesium oxide / hydroxyapatite porous composite material, specifically comprising the following steps:

[0033] (1) Nano-zinc oxide with a purity of ≥99.7% and a particle size of 200-300nm, nano-magnesium oxide with a purity of ≥99.9% and a particle size of 100-200nm, and nano-hydroxyphosphorus with a purity of ≥99.9% and a particle size of 150-300nm Limestone is used as raw material, wherein the mass percentage of zinc oxide is 1%, the mass percentage of magnesium oxide powder is 1%, and the mass percentage of hydroxyapatite is 98%.

[0034] (2) Put the powder weighed in step (1) into an agate ball mill jar, and put in an appropriate amount of agate balls (the ratio of agate balls and raw materials is 3:1, wherein the mass ratio of agate balls is large ball: medium ball: small ball=1:4:5), and add appropriate amount of absolute ethanol and dispersant (dispersant is Span 80, its chemical formula is C 24 h 44 o 6 , pharmaceutical gra...

Embodiment 2

[0039] (1) Nano-zinc oxide with a purity of ≥99.7% and a particle size of 200-300nm, nano-magnesium oxide with a purity of ≥99.9% and a particle size of 100-200nm, and nano-hydroxyphosphorus with a purity of ≥99.9% and a particle size of 150-300nm Limestone is used as raw material, wherein the mass percentage of zinc oxide is 3%, the mass percentage of magnesium oxide powder is 3%, and the mass percentage of hydroxyapatite is 94%.

[0040] (2) Put the powder weighed in step (1) into an agate ball mill jar, and put in an appropriate amount of agate balls (the ratio of agate balls and raw materials is 4:1, wherein the mass ratio of agate balls is large ball: medium ball: small ball=2:7:9), and add appropriate amount of absolute ethanol and dispersant (dispersant is Span 80, its chemical formula is C 24 h 44 o 6 , pharmaceutical grade, the amount added is 0.5% of the original powder mass); ball milling at a speed of 300r / min for 8h. After ball milling, drying (drying temperatu...

Embodiment 3

[0045] (1) Nano-zinc oxide with a purity of ≥99.7% and a particle size of 200-300nm, nano-magnesium oxide with a purity of ≥99.9% and a particle size of 100-200nm, and nano-hydroxyphosphorus with a purity of ≥99.9% and a particle size of 150-300nm Limestone is used as a raw material, wherein the mass percentage of zinc oxide is 5%, the mass percentage of magnesium oxide powder is 5%, and the mass percentage of hydroxyapatite is 90%.

[0046] (2) Put the powder weighed in step (1) into an agate ball mill jar, and put in an appropriate amount of agate balls (the ratio of agate balls and raw materials is 3:1, wherein the mass ratio of agate balls is large ball: medium ball: small ball=1:4:9), and add appropriate amount of absolute ethanol and dispersant (dispersant is Span 80, its chemical formula is C 24 h 44 o 6 , pharmaceutical grade, the amount added is 0.4% of the original powder mass); ball milling at a speed of 400r / min for 10h. After ball milling, dry and grind.

[00...

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Abstract

The invention discloses a preparation method of a zinc oxide-magnesium oxide / hydroxyapatite porous composite material, and belongs to the technical field of biomedical materials. The method comprises the following steps: by taking nano zinc oxide, magnesium oxide and nano hydroxyapatite powder as raw materials, proportioning the zinc oxide, the magnesium oxide powder and hydroxyapatite according to a mass ratio of (1-10%): (99-90%), and carrying out weighing, ball-milling, drying and grinding to obtain composite powder; mixing the composite powder with medical-grade ammonium bicarbonate according to a volume percentage ratio of (40-80%): (60-20%), uniformly mixing, and pressing to obtain a long-strip-shaped green body; and preparing the zinc oxide magnesium oxide / hydroxyapatite porous composite material by spark plasma sintering. The porosity of the prepared composite material is 20%-60%, the pore size is 100-500 [mu] m and is controllable, and the composite material meeting various different requirements, such as bone scaffolds, bone filling and repair materials of hard tissue defect parts, can be prepared according to actual requirements.

Description

technical field [0001] The invention relates to a preparation method of a zinc oxide-magnesia / hydroxyapatite porous composite material, which belongs to the preparation technology in the field of biomedical materials. Background technique [0002] Biomedical composite materials refer to biomedical materials composed of two or more different biomedical materials, which are mainly used for the repair and replacement of human tissue and the manufacture of artificial organs. There are many natural composite materials in nature and human tissues, such as human bone, which is a fiber-reinforced composite material composed of collagen, protein and inorganic substances. The traditional single type of biomedical materials can meet the needs of biomedicine in some aspects, but it can not meet the standards in other aspects, and even produce adverse effects, which cannot meet the clinical application. Biomedical materials made of materials with different properties not only have the p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B35/447C04B35/622C04B38/02A61L27/42A61L27/56A61L27/58A61L27/50
CPCC04B35/447C04B35/622C04B38/02A61L27/425A61L27/56A61L27/58A61L27/50C04B2235/3206C04B2235/3284C04B2235/3208C04B2235/5445C04B2235/6581C04B2235/6562C04B2235/6567C04B2235/96A61L2430/02C04B38/0074C04B38/0051
Inventor 孟增东李晶莹罗丽琳张玉勤朱斌
Owner FIRST PEOPLES HOSPITAL OF YUNNAN PROVINCE