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Preparation process of high-purity nicotine

A preparation process and technology of nicotine, which is applied in the field of industrial waste resource treatment, can solve the problems of high energy consumption, large solvent loss, and long time, and achieve the effects of improving economic benefits, reducing dosage, and shortening time

Inactive Publication Date: 2021-04-02
NORTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, it is necessary to improve this process to reduce energy consumption and improve efficiency in view of the long extraction and concentration process, large solvent loss, and high energy consumption.

Method used

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  • Preparation process of high-purity nicotine

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Effect test

Embodiment 1

[0019] Add 500L 40% nicotine sulfate to the 1000L jacketed reactor, then add 175L 32% NaOH, stir at room temperature for 15 minutes, then circulate water to cool the system until the system is maintained at 9°C, and let it stand for 2.5 hours. During this period, a little stirring can be used to promote the precipitation of crystals. After the precipitation is complete, centrifuge and filter, and the crude product sodium sulfate decahydrate obtained by filtration can be used for the preparation of anhydrous sodium sulfate. The filtrate was heated to 80°C with slow stirring in the heating kettle, then the temperature was kept and the stirring was stopped, and the mixture was left to stand for 20 minutes to wait for obvious separation. The upper organic layer (about 280 L) was separated and dried over 20 kg of anhydrous sodium sulfate. The lower aqueous phase (about 390L) is extracted with 1200L No. 6 solvent oil (centrifugal extraction or disc extraction), the extract is conce...

Embodiment 2

[0021] Add 400L 45% nicotine sulfate to a 1000L jacketed reactor, then add 140L 35% NaOH, stir at room temperature for 15 minutes, then circulate water to cool the system until the system is maintained at 7°C, and let stand for 2.5 hours; centrifuge and filter the obtained crude product after the precipitation is complete Sodium sulfate decahydrate was used for the preparation of anhydrous sodium sulfate; the filtrate was slowly stirred and heated to 82°C in a heating kettle, then kept at the temperature and stopped stirring, and stood for 20 minutes to wait for obvious separation. About 220 L of the upper organic layer was separated and dried with 20 kg of anhydrous sodium sulfate. The lower aqueous phase (about 320L) is extracted with 1000L No. 6 solvent oil (centrifugal extraction or disc extraction), the extract is concentrated under reduced pressure, the solvent is recovered, and the concentrated crude nicotine is combined with the above crude nicotine for rectification ....

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Abstract

The invention discloses a novel process for preparing high-purity nicotine from nicotine sulfate, and the process specifically comprises the following steps: neutralizing a 35-55% nicotine sulfate aqueous solution with a 25-35% sodium hydroxide aqueous solution, cooling the system after neutralization, keeping the temperature of the solution at 5-10 DEG C, and performing standing; performing filtering after the sodium sulfate decahydrate precipitates completely; heating the filtrate to 75-85 DEG C, standing for layering, collecting upper-layer nicotine after layering, performing drying to remove water, performing filtering to obtain coarse nicotine, and rectifying the coarse nicotine to obtain high-purity nicotine. The method can greatly reduce the consumption of the extraction agent and the energy consumption of evaporation and concentration of the extraction liquid, saves energy, reduces emission, and shortens the process time.

Description

technical field [0001] The invention relates to a new process for preparing high-purity nicotine from nicotine sulfate, which belongs to the technical field of industrial waste resource treatment. Background technique [0002] As a big country in tobacco production and processing, my country's annual profits and taxes created by the tobacco industry have exceeded one trillion yuan since 2014. In 2017, the national production of tobacco leaves exceeded 2.39 million tons. my country produces nearly 100,000 tons of waste tobacco powder and tobacco stems in the process of tobacco processing every year. Part of this waste is processed through fermentation to prepare biochemical fertilizers, and the other part is used to produce nicotine sulfate as a high-purity Raw material for nicotine preparation or biopesticide. High-purity nicotine is an important raw material for electronic cigarettes and pharmaceutical intermediates, with extremely high added value and a large market gap. ...

Claims

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Application Information

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IPC IPC(8): C07D401/04
CPCC07D401/04
Inventor 王晨宋一鸣管玉雷王洋洋秦浩
Owner NORTHWEST UNIV
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