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Method for preparing functional postoperative anti-adhesion material through 3D printing

A 3D printing and shaping technology, used in surgery, pharmaceutical formulations, medical science, etc., can solve problems such as application limitations, adhesion failure of anti-adhesion materials, etc., to achieve safe handling and use, keep the wound moist, and meet individual requirements. Effect

Active Publication Date: 2021-04-09
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims to solve the problem that the existing postoperative anti-adhesion materials are prone to bonding failure and the application in complex wounds is limited, and proposes a method for preparing functional postoperative anti-adhesion materials by 3D printing

Method used

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  • Method for preparing functional postoperative anti-adhesion material through 3D printing

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specific Embodiment approach 1

[0033] Specific Embodiment 1: In this embodiment, the method for preparing functional postoperative anti-adhesion materials by 3D printing is carried out according to the following steps:

[0034] One, the preparation of N, O-carboxymethyl chitosan:

[0035] Add chitosan powder into isopropanol, stir magnetically for 8-24h at a temperature of 25-80°C, then add NaOH solution to the mixed solution every 5min, add NaOH solution 5-12 times in total, and then Add chloroacetic acid dropwise to the mixed solution 5 times within 20 minutes, adjust the temperature of the reaction solution to 40-80°C for 2-8 hours, stop the reaction with an excess of 75-80v / v% ethanol aqueous solution, and then use 75- Wash the precipitate with 80v / v% ethanol aqueous solution for 2-4 times, then continue to wash with absolute ethanol for 3-5 times, and finally dry the precipitate in a vacuum oven to obtain a water-soluble N,O-carboxymethyl shell Glycans (N,O-CS);

[0036] 2. Preparation of aldehydated...

specific Embodiment approach 2

[0046] Embodiment 2: This embodiment differs from Embodiment 1 in that: the drying time in step 1 is 18-24 hours, and the drying temperature is 40-60°C.

specific Embodiment approach 3

[0047] Specific embodiment three: this embodiment is different from body implementation one or two: the ratio of the quality of chitosan described in step one and the volume of isopropanol is 1g: (5-12) mL; Said chitosan The ratio of the mass of NaOH solution to the volume of all the NaOH solutions added is 1g:2.5mL; the concentration of NaOH solution is 10mol / L; the mass ratio of chitosan to chloroacetic acid is 1:(2-6). The chitosan is milky white powder, the degree of deacetylation is 80%, and the grade is medical grade.

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Abstract

The invention discloses a method for preparing a functional postoperative anti-adhesion material through 3D printing, relates to a method for preparing an anti-adhesion material, and aims to solve the problems that an existing postoperative anti-adhesion material is prone to suffer from cohesion failure, and application of the existing postoperative anti-adhesion material in complicated wounds is limited. The method comprises the following steps: preparing N, O-carboxymethyl chitosan, preparing aldehyde oxidized cellulose nanofibers, preparing dopamine modified oxidized cellulose nanofibers, dissolving the N, O-carboxymethyl chitosan, epsilon-polylysine and the dopamine modified oxidized cellulose nanofibers in deionized water and performing mixing to obtain printing ink, and performing 3D printing. The hydrogel disclosed by the invention has the characteristics of high wet adhesion, self-repairability, high strength, high toughness, softness, is prone to fit with skin and the like, and has the functions of resisting bacteria, stopping bleeding, controlling degradation, absorbing tissue exudate, keeping a wound surface moist and effectively promoting healing, and the usage amount can be accurately controlled by 3D printing to meet individual requirements of patients. The method is suitable for preparing the postoperative anti-adhesion material.

Description

technical field [0001] The invention relates to a method for preparing an anti-adhesion material. Background technique [0002] Postoperative adhesions are the most common adverse reaction after surgery, affecting millions of people worldwide and costing billions of dollars in medical costs. The formation of postoperative adhesions will lead to many serious consequences, such as chronic pain, female infertility, intestinal obstruction, etc., which not only increases the pain and financial burden of patients, but also seriously affects the daily life of patients. Especially in the field of obstetrics and gynecology, postoperative adhesions may occur in all women who undergo relatively simple operations such as ovarian cystectomy, hysteromyomectomy, and tubal plastic surgery. Therefore, the prevention of postoperative adhesions has become an important issue that all doctors urgently need to solve. [0003] Current adhesion prevention materials include solid polymers or hydro...

Claims

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Application Information

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IPC IPC(8): A61L31/04A61L31/06A61L31/14A61L31/16D06M13/368
CPCA61L31/041A61L31/042A61L31/14A61L31/148A61L31/16A61L2300/232A61L2300/404A61L2300/418A61L2400/04D06M13/368D06M2101/06C08L77/04C08L5/08C08L1/04
Inventor 程凤栗洪彬贺金梅黄玉东
Owner HARBIN INST OF TECH
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