Fluorine-containing antibacterial invisible appliance for improving enamel demineralization and preparation method of fluorine-containing antibacterial invisible appliance

Abstract

The invention discloses a fluorine-containing antibacterial invisible appliance for improving enamel demineralization and a preparation method of the fluorine-containing antibacterial invisible appliance. The appliance can effectively release fluorine and promote remineralization of a demineralized tooth surface, and is good and stable in antibacterial performance, good in biocompatibility and ideal in appearance. and lysozyme and the fluorine-containing hyaluronic acid are fixed through a layer-by-layer self-assembly method, the fluorine-containing antibacterial invisible appliance with the lysozyme antibacterial property and the fluorine remineralization promoting property is obtained, the biocompatibility of the lysozyme and the hyaluronic acid is good, the cost is low, and the efficiency is high. The fluorine-containing antibacterial appliance prepared by the invention can promote remineralization of enamel, can also inhibit generation and development of gingivitis, caries, dental pulp diseases and periodontitis related to bacteria, is simple, efficient and pollution-free in preparation process, and has a wide clinical application prospect.

Description

technical field [0001] The invention belongs to the technical fields of material modification and stomatology. More specifically, it relates to a fluorine-containing antibacterial invisible appliance for improving tooth enamel demineralization and a preparation method thereof. Background technique [0002] Invisible aligners have gradually become one of the mainstream orthodontic methods due to their advantages of being removable, easy to clean, beautiful, and comfortable. However, with the expansion of the population of patients wearing clear aligners, the complications caused by clear aligners are also gradually revealed. For example, clear aligners cover a large area of ​​the tooth surface and wear them for a long time, which can affect the oral microenvironment and increase the abundance of bacterial flora. Increase; the acid etching of the tooth surface and the rough surface around the attachment during the bonding process of the invisible appliance attachment can also...

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Problems solved by technology

[0003] So far, many appliances with antibacterial effects have been reported to prevent and treat related diseases caused by bacteria. For example, Chinese patent application 201110192472.8 discloses a radio frequency magnetron sputtering method to attach nitrogen-doped TiO2- The method of xNx thin film, but the reaction temperature of this method is high, it is difficult to promote in invisible appliances; Controlled sputtering ion plating equipment is expensive and the procedure is complicated, and due to the introduction of inorganic nanomaterials, it is difficult to ensure good biocompatibility of appliances; Chinese patent application 202010062403.4 provides antibacterial products formed by tertiary ammonization and in-situ quaternization Although invisible aligners avoid the release of antibacterial agents into human metabolism and affect biological safety, the grafted group is still an exogenous substance, and there is still a gap with the ideal biocompatibility, and the production process involves a variety of chemical reactions , the steps are more complicated

However, the manufacturing method of the antibacterial appliance products disclosed above has disadvantages such as expensive equipment, complicated operation, and high cost, and the antibacterial raw materials used are inorganic metals and their composites with poor biocompatibility

In addition, the above technologies only consider the antibacterial problem and do not involve the promotion of tooth enamel mineralization. The function is single and cannot fully meet the needs of consumers.

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