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A kind of traditional Chinese medicine composition for treating allergic rhinitis and application thereof

A technology for allergic rhinitis and composition, which is applied to a traditional Chinese medicine composition for the treatment of allergic rhinitis and its application field, can solve the problems of systemic hormone side effects, unsatisfactory treatment effect and the like, and achieves the effect of improving the pathology of rhinitis

Active Publication Date: 2022-05-10
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the therapeutic effects of western medicine are not satisfactory in clinic. The local application of corticosteroids in the nasal cavity is used for anti-allergy, and the local application of ephedrine in the nasal cavity is mainly used to shrink blood vessels.
Topical application of corticosteroids in the nasal cavity will be absorbed into the blood for long-term application, causing side effects of systemic hormones

Method used

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  • A kind of traditional Chinese medicine composition for treating allergic rhinitis and application thereof
  • A kind of traditional Chinese medicine composition for treating allergic rhinitis and application thereof
  • A kind of traditional Chinese medicine composition for treating allergic rhinitis and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Take 1000 grams of cloves and add 6000mL of water, steam distillation to obtain an extract containing eugenol (eugenol purity 80%), distill twice to obtain a final volume of 10000mL, i.e. clove extract solution; after low-temperature vacuum concentration, you can get Clove extract (about 100g), wherein the eugenol purity is 80%.

[0058] Take 1000 grams of astragalus, add 5000 mL of 70% ethanol to extract twice, evaporate the ethanol, add to D101 resin column, after adsorption for half an hour, wash with 5 times the column volume of water, then wash the column with 0.2% NaOH, wash with water until neutral, Rinse the column with 20% ethanol, then wash the column with 70% ethanol and collect, and evaporate the ethanol to obtain 2000 mL of Astragalus extract solution rich in total astragalosides (purity of total astragalus saponins is 70%), add 0.3% potassium sorbate for later use. Wherein, after evaporating ethanol, drying can obtain Radix Astragali extract (about 20 g), ...

Embodiment 2

[0063] Purchase 10g eugenol (purity 90%) from the market, dissolve it with Tween 80, and dilute it to 1000mL; purchase 20g total saponins of astragalus (purity 90%) from the market, dissolve it with Tween 80, and dilute it to 1000mL; press 1: 1 mixed, divided into 200 bottles of 10mL nasal drops.

Embodiment 3

[0065] Get 1000 grams of cloves, crush them into coarse powder, place them in a supercritical extraction device, and extract them at a pressure of 25 MPa and a temperature of 55° C., analyze them at a pressure of 6 MPa and a temperature of 40° C., and obtain a light yellow translucent extract 100 gram (eugenol purity 80%), add solubilizer Tween 80 and dilute to obtain a final volume of 10000mL, i.e. clove extract solution.

[0066] Take 1000 grams of Astragalus membranaceus, add 5000 mL of water to extract twice, concentrate and extract with n-butanol saturated with water, take the n-butanol layer liquid, wave off the n-butanol, wash with absolute ethanol, dissolve in water, and obtain 2000 mL of astragalus total saponins rich in The extract solution (purity of total astragalus saponins 70%), add 0.3% potassium sorbate for subsequent use. Wherein, after washing with absolute ethanol, drying, the extract of Radix Astragali (about 20 g) can be obtained, and the purity of total s...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating allergic rhinitis and application thereof. The traditional Chinese medicine composition consists of eugenol and total astragalus saponins. The nasal spray made of the traditional Chinese medicine composition can be used for the treatment of allergic rhinitis through local nasal administration. The experimental drug effect is better than the first-line treatment drug, and the effect is fast, and it can take effect within 1 to 3 minutes after spraying. , reduce nasal congestion, runny nose, etc., without side effects, and can have a radical effect on some people. After administration to rats, the results illustrate: Dinghuang group nasal spray of the present invention is superior to triamcinolone acetonide (positive control group) in reducing allergy main mediator IgE, reducing nasal mucous membrane secretory mucin MUC5AC, improving rhinitis pathology (positive control group), clove The combination of phenol and total astragalus saponins has brought into play a synergistic effect, and the effect is more than single use of eugenol and total astragalus saponins.

Description

technical field [0001] The invention relates to a nasal spray and nasal drops for treating allergic rhinitis with a combination of active ingredients of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating allergic rhinitis and its application. The traditional Chinese medicine composition consists of eugenol and total astragalus saponins. The nasal spray prepared from the traditional Chinese medicine composition of the invention can be used to treat allergic rhinitis, and the experimental drug effect is better than that of the first-line treatment drug: corticosteroid preparation, and has no side effects of hormone drugs. Background technique [0002] Allergic rhinitis (allergic rhinitis) is a disease mainly characterized by immune allergy and chronic inflammation with sneezing, runny nose, nasal congestion and nasal itching as the main clinical symptoms, affecting the quality of life of more than 20% of the world's populati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/481A61K36/61A61K9/12A61K9/06A61K9/08A61K47/10A61K47/32A61P11/02A61P37/08A61K31/085
CPCA61K31/085A61K36/481A61K36/61A61K9/0043A61K9/08A61K9/12A61K9/06A61K47/10A61K47/32A61P11/02A61P37/08A61K2236/331A61K2236/39A61K2236/333A61K2236/55A61K2236/35A61K2300/00
Inventor 王剑
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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