Preparation method of magnesium/hydroxyapatite porous composite material

A technology of porous composite materials and hydroxyapatite, which is applied in the field of preparation of biomedical materials, can solve the problems of uneven composition structure, cell toxicity, induced inflammation, etc., and achieve the effect of avoiding rapid degradation and HA decomposition

Inactive Publication Date: 2021-04-13
FIRST PEOPLES HOSPITAL OF YUNNAN PROVINCE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is: the composition and structure of the magnesium or magnesium alloy-porous hydroxyapatite composite material prepared by the existing method is not uniform, and there is a risk of inducing inflammation and causing cell toxicity

Method used

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  • Preparation method of magnesium/hydroxyapatite porous composite material
  • Preparation method of magnesium/hydroxyapatite porous composite material
  • Preparation method of magnesium/hydroxyapatite porous composite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) Metal magnesium powder with a purity of 99.95-99.99% and a particle size of 10-20 μm and nano-hydroxyapatite with a purity of ≥99.9% and a particle size of 150-300 μm are used as raw materials, wherein magnesium powder and nano-hydroxyapatite According to the mass ratio of 1%:99% for proportioning.

[0032] (2) Put the powder weighed in step (1) into a stainless steel ball mill tank, put in an appropriate amount of stainless steel balls according to the ball-to-material ratio of 4:1, and evacuate it to 8Pa. The above process is carried out in a vacuum glove box Finished in middle; fixed on the planetary ball mill, ball milled at 200r / min for 2h; after the tank temperature dropped to room temperature, vacuum the tank again to 8Pa, and ball milled at 300 / min for 6h.

[0033] (3) Pour the slurry obtained in step (2) into a petri dish in a vacuum glove box, put the petri dish into a vacuum drying oven, the drying temperature in the oven is 35°C, and the vacuum degree is...

Embodiment 2

[0037](1) Using metal magnesium powder with a purity of 99.95-99.99% and a particle size of 10-20 μm and nano-hydroxyapatite with a purity of ≥99.9% and a particle size of 150-300 μm as raw materials, magnesium powder and nano-hydroxyapatite by The mass ratio is 3%: 97% for proportioning and weighing.

[0038] (2) Put the powder weighed in step (1) into a stainless steel ball mill jar, and put in an appropriate amount of stainless steel grinding balls according to the ball-to-material ratio of 3:1, wherein the mass ratio of the grinding balls is large ball: medium ball: small ball = 2:8:15, and vacuumize it to 9Pa, the above process is completed in a vacuum glove box; fix it on a planetary ball mill, and ball mill it at a speed of 200r / min for 2h; after the tank temperature drops to room temperature, The tank was evacuated to 9Pa again, and ball milled at a speed of 300 / min for 8 hours.

[0039] (3) Pour the slurry obtained in step (2) into a petri dish in a vacuum glove box,...

Embodiment 3

[0043] (1) Using metal magnesium powder with a purity of 99.95-99.99% and a particle size of 10-20 μm and nano-hydroxyapatite with a purity of ≥99.9% and a particle size of 150-300 μm as raw materials, magnesium powder and nano-hydroxyapatite by The mass ratio is 5%:95% for proportioning and weighing.

[0044] (2) Put the powder weighed in step (1) into a stainless steel ball mill jar, and put in an appropriate amount of stainless steel grinding balls according to the ball-to-material ratio of 3:1, wherein the mass ratio of the grinding balls is large ball: medium ball: small ball = 2:8:15, and vacuumize it to 10Pa, the above process is completed in a vacuum glove box; fix it on a planetary ball mill, and ball mill it at a speed of 300r / min for 2h; after the tank temperature drops to room temperature, The tank was evacuated to 10Pa again, and ball milled at a speed of 400 / min for 8 hours.

[0045] (3) Pour the slurry obtained in step (2) into a petri dish in a vacuum glove bo...

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Abstract

The invention discloses a preparation method of a magnesium/hydroxyapatite porous composite material, and belongs to the technical field of biomedical materials. The preparation method of the magnesium/hydroxyapatite porous composite material comprises the following steps: taking metal magnesium powder and nano-hydroxyapatite as raw materials, wherein the magnesium powder and nano-hydroxyapatite are proportioned according to a mass ratio of (1%-10%): (99%-90%), and then, carrying out weighing, ball-milling, drying and grinding so as to obtain composite powder; mixing the composite powder with medical-grade ammonium bicarbonate according to a volume percentage ratio of (40%-60%): (60%-40%), and carrying out uniform mixing and pressing so as to obtain a long-strip-shaped green body; and then, carrying out spark plasma sintering so as to obtain the magnesium/hydroxyapatite porous composite material. The prepared composite material has a porosity of 40%-60%; and the pores are 100-500 [mu] m in size and controllable; Therefore, composite materials meeting various different requirements, such as bone scaffolds, bone fillers, repair materials of hard tissue defect parts and the like. can be prepared according to actual requirements.

Description

technical field [0001] The invention relates to a preparation method of a magnesium / hydroxyapatite porous composite material, which belongs to the preparation technology in the field of biomedical materials. Background technique [0002] Biomedical composite materials refer to biomedical materials composed of two or more different biomedical materials, which are mainly used for the repair and replacement of human tissue and the manufacture of artificial organs. There are many natural composite materials in nature and human tissues, such as human bone, which is a fiber-reinforced composite material composed of collagen, protein and inorganic substances. The traditional single type of biomedical materials can meet the needs of biomedicine in some aspects, but it can not meet the standards in other aspects, and even produce adverse effects, which cannot meet the clinical application. Biomedical materials made of materials with different properties not only have the properties ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/04A61L27/12A61L27/54A61L27/50B22F3/11B22F9/04C22C29/00C22C1/08
CPCA61L27/56A61L27/047A61L27/12A61L27/54A61L27/50B22F3/1134B22F9/04C22C29/005A61L2430/02A61L2300/102A61L2300/412A61L2300/602B22F2009/043
Inventor 孟增东张玉勤罗丽琳朱斌李晶莹
Owner FIRST PEOPLES HOSPITAL OF YUNNAN PROVINCE
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