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Alginate soft capsule and preparation method thereof

An alginate and soft capsule technology, which is applied in the directions of capsule delivery, pharmaceutical formulations, and non-active ingredients medical preparations, can solve the problems of uneven thickness of the capsule, deformation of the soft capsule, and lack of heat-sealing properties. Avoid local deformation or even leakage of capsule material, precise fixed-point disintegration function, and protect the gastrointestinal tract

Inactive Publication Date: 2021-04-20
南京健辉生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since the alginate capsule material is not heat-sealable, the compression method in the traditional gelatin soft capsule production process cannot be used to prepare alginate soft capsules, and the cross-linking reaction between the alginate capsule material and multivalent metal ions is too high. If it is too fast, the formed droplets will solidify due to the cross-linking reaction before they can form a spherical shape under the action of surface tension, resulting in defects such as deformation of the soft capsule and uneven thickness of the capsule skin. Therefore, it is not suitable for the traditional gelatin soft capsule production process. Alginate Soft Capsules Prepared by Dropping Method

Method used

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  • Alginate soft capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046]A alginate soft capsule, prepared, including the following steps:

[0047]S1, potassium alginate 1 kg, 50 grams of endozogene, dissolved in 100 kg of purified water at 80 ° C, forming a transparent gel fluid;

[0048]S2, using fully automatic drip soft capsule production equipment (RDW-P type drip soft capsule machine, Beijing Xinhang Science Technology Development Co., Ltd.), content object is soybean oil, gel fluid and contents in double tap The outer layer flows out at different speeds, dripped into liquid paraffin, gradually cooled, solidified into spherical soft capsules (thermal reverse gel), alcohol to clean the surface of the soft capsule after collecting liquid paraffin;

[0049]S4, the cage is dried at room temperature, and the product made is oral disintegration or rapidly disintegration soft capsule.

[0050]Oral disintegration or rapid disintegration refers to disintegrating within 10 minutes in neutral water.

[0051]In this embodiment, since the crosslinking reaction is not re...

Embodiment 2

[0053]A algarate soft capsule, based on the components and preparation methods of Example 1, further comprising step S3, the soft capsule (thermocracked gelatin) collected by step S2 in Example 1 is 0.1% calcium with a mass concentration of 0.1%. The aqueous solution was soaked for 5 minutes;

[0054]Then, the product made by step S4 is a small intestinal collapsed soft capsule.

[0055]Small intestinal collapsed soft capsules refer to a soft capsule that is not disintegrated in neutral water and 120 minutes in artificial gastric juice, in 30 minutes within 30 minutes of artificial medium.

[0056]In this embodiment, in step S3, a multivalent metal ion crosslinking treatment of a relatively short time of a lower concentration is transmitted, and the multivalent metal ion is diffused into the superficial outer layer of thermoformed gel, soft capsules. The outer layer of the capsule forms a thinner thermal irreversible gel. The inner layer of the capsule is still a heat-reversible gel that doe...

Embodiment 3

[0058]An alginate soft capsule, based on the components and preparation methods of Example 1, further comprising step S3, a soft capsule (thermocracked gel) collected in Example 1 with a mass concentration of 5% chlorine Soak for 20 minutes;

[0059]Then, the product made by step S4 is a colon disintegration soft capsule.

[0060]Colon disintegration soft capsules refer to neutralized water, artificial gastric liquid, artificial intestinal fluid each 120 minutes without disintegration, in a 30-minute soft capsule that is 30 minutes in artificial colon liquid.

[0061]In this embodiment, the multivalent metal ion can diffuse into the deeper ,,,,,,,,,,,,,,,,,,,,,,,,,,, The outer layer of the capsule forms a layer of thick thermal irreversible gelatin, and the inner layer of the capsule is still a heat-reversible gel without the multivalent metal ion reaction, and the capsule material produced by step S4 is contained in the capsule material produced by step S4. More multivalent metal ions, thic...

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Abstract

The invention discloses an alginate soft capsule. A capsule material comprises thermal reversible gel, and the alginate soft capsule is prepared by dissolving a monovalent alginate salt and the thermal reversible gel in water in parts by mass and treating obtained thermal reversible gel liquid through a dropping or pressing process of the soft capsule. Through the thermal reversible gel, the capsule material has heat sealability and condensation formability, and meanwhile, the capsule material has feasibility of further carrying out a cross-linking reaction with a thermal irreversible gel initiator; a thermal irreversible gel layer can be accurately regulated and controlled by accurately regulating and controlling the thermal irreversible gel initiator; as a protective layer, the thermal irreversible gel layer can achieve a disintegration effect of the soft capsule on different parts of a digestive tract; and the thermal reversible gel layer can realize wrapping forming and instant dissolution of contents of the soft capsule. The alginate soft capsule disclosed by the invention can be completed by adopting a dropping method or a pressing method in an existing gelatin soft capsule production process; and a preparation method is simple, the cost is low, new process equipment does not need to be added, and quite high practicability and wide applicability are achieved.

Description

Technical field[0001]The present invention relates to a soft capsule, and more particularly to a beehalose soft capsule and a preparation method thereof.Background technique[0002]Soft capsules are used as a common package of liquid content, and have the advantages of convenient use, absorption and other advantages, and are widely accepted by consumers. At present, the soft capsules on the market are gelatin soft capsules made from gelatin as the main capsules, while gelatin is made by more and more plant soft capsules products due to their own animal sources and food safety issues. Reporting, alginate soft capsules are one of the soft capsules having large application prospects.[0003]The alginate is a natural vegetable polysaccharide material that is primarily extracted from the brown algae. Its maximum feature is that the ion crosslinking reaction can be generated with a number of valence metal cations, which is rapid, and the temperature is rapid. Insensitive, the gel can be forme...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/36A61K47/02
Inventor 张文辉刘凤彩
Owner 南京健辉生物科技有限公司
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