The invention discloses a waterproof and oil-proof agent. The waterproof and oil-proof agent comprises thermoplastic waterproof and oil-proof acrylic resin and thermoplastic reinforced acrylic resin, the thermoplastic waterproof and oil-proof acrylic resin contains a waterproof monomer and an oil-proof monomer; the waterproof monomer comprises an acrylate monomer and a styrene monomer; the oil-proof monomer is an acrylate monomer containing at least one of hydroxyl, amino and carboxyl; and the thermoplastic reinforced acrylic resin contains a self-crosslinking group. According to the waterproof and oil-proof agent, domestic acrylic resin is adopted, the cost is lower, two kinds of acrylic resin with different functions are adopted, the double-acrylic resin is scientifically compounded, a coating can be endowed with waterproof, oil-proof, temperature-resistant, non-sticky and peelable functions, when the waterproof and oil-proof agent is applied to paper-based packaging, a paper base can be re-pulped and recycled, and the adopted acrylic resin has heat sealability, so that the paper material of which the surface is coated with the waterproof and oil-proof agent can be directly heat-sealed and molded into various paper-based packages, and the paper material does not contain fluorine, and is non-toxic and odorless.