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A pharmaceutical composition for preventing and treating hypertensive inflammatory response and its application

A technology of inflammatory response and composition, which is applied in the field of research and development of traditional Chinese medicine, and can solve the problems of undiscovered modern Chinese patent medicine varieties on the market.

Active Publication Date: 2022-06-24
SHANDONG ACAD OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Banxia Baizhu Tianma Decoction was included in the "Catalogue of Ancient Classical Prescriptions (First Batch)" issued by the State Administration of Traditional Chinese Medicine in 2018. It is one of the first batch of 100 classic famous prescriptions. No modern Chinese patent medicines have been found so far Variety listed

Method used

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  • A pharmaceutical composition for preventing and treating hypertensive inflammatory response and its application
  • A pharmaceutical composition for preventing and treating hypertensive inflammatory response and its application
  • A pharmaceutical composition for preventing and treating hypertensive inflammatory response and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Preparation of Syrup for Prevention and Treatment of Hypertension and Inflammation:

[0054] Take 110g of gastrodin, 30g of hesperidin, 40g of salicylic acid A, 100g of liquiritigenin and 150g of isoliquiritigenin, add appropriate amount of water to dissolve, stir, let stand, filter, add 250g of sucrose, 5g of sodium benzoate, add 1000ml of water, stir well , filling, sterilization, that is.

Embodiment 2

[0056] Preparation of dripping pills for preventing and treating hypertensive inflammation:

[0057] Take 45 g of gastrodin, 80 g of hesperidin, 92 g of salicylic acid, 180 g of liquiritigenin, 160 g of isoliquiritigenin, and 500 g of polyethylene glycol, heat to melt, mix well, transfer to the liquid reservoir of the pill-dropping machine, and keep the temperature at 90°C , drop into the cooled simethicone to make 1000g dropping pills.

Embodiment 3

[0059] Preparation of capsules for preventing and treating hypertensive inflammatory response:

[0060] Take 55 g of gastrodin, 75 g of hesperidin, 50 g of salicylic acid A, 100 g of liquiritigenin, and 170 g of isoliquiritigenin, add an appropriate amount of starch, mix well, put into capsules, and make 1,000 capsules.

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PUM

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Abstract

The invention belongs to the field of research and development of traditional Chinese medicines, and in particular relates to a pharmaceutical composition for preventing and treating hypertensive inflammatory response and its application. The pharmaceutical composition is composed of 3.2-12.8 parts of gastrodin; 2.4-9.6 parts of hesperidin; 2.5-10 parts of pachymic acid A; 5.3-21.2 parts of liquiritigenin and 4.5-18 parts of isoliquiritigenin. The potency of the pharmaceutical composition prepared by the invention to prevent or slow down the inflammatory response of hypertension can reach 98.77%. The pharmaceutical composition of the present invention does not contain the toxic components of Pinellia oxalate calcium oxalate needle crystals and lectin protein, avoiding the irritation and harm caused by the original prescription of Pinellia Baizhu Tianma Decoction on the human body, and can be used with confidence, and the curative effect is enhanced; finally, it is further developed Formulation of novel active ingredient combinations lays the foundation.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine research and development, and particularly relates to a pharmaceutical composition for preventing and treating hypertensive inflammatory reaction and its application. Background technique [0002] Hypertension is a systemic low-grade inflammatory disease. In recent years, accumulating evidence points to abnormal immune activation as an important factor in the development of elevated blood pressure and hypertensive pathology. Under the changes of blood flow rate and pressure in high blood pressure, red blood cells are stimulated and actively release a large number of ATP molecules. The homeostasis of blood pressure is maintained by the co-regulation of the cardiovascular, autonomic nervous system, kidney, etc., but the occurrence of inflammation impairs the regulatory functions of these systems, resulting in increased blood pressure. [0003] Banxia Baizhu Tianma Decoction originated f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P9/12A61P29/00A61K31/122A61K31/353A61K31/575A61K31/7034
CPCA61K31/7034A61K31/7048A61K31/575A61K31/353A61K31/122A61P9/12A61P29/00A61K2300/00
Inventor 徐男王平
Owner SHANDONG ACAD OF CHINESE MEDICINE