Glucosamine chondroitin tablet containing active peptide and organic calcium and preparation method of glucosamine chondroitin tablet

A technology of plain tablets and active peptides, which is applied in the field of glucosamine chondroitin tablets and its preparation, can solve the problems of tablet mold damage, unfavorable large-scale production, and low absorption and utilization rate of calcium ions

Active Publication Date: 2021-04-30
SHENZHEN TAITAI PHARMA IND +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the glucosamine products currently on the market for increasing bone density generally contain glucosamine, chondroitin sulfate, calcium carbonate and collagen as the main ingredients. The release efficiency of calcium ions is poor, and there are also problems of poor stability, resulting in low absorption and utilization of calcium ion...

Method used

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  • Glucosamine chondroitin tablet containing active peptide and organic calcium and preparation method of glucosamine chondroitin tablet
  • Glucosamine chondroitin tablet containing active peptide and organic calcium and preparation method of glucosamine chondroitin tablet
  • Glucosamine chondroitin tablet containing active peptide and organic calcium and preparation method of glucosamine chondroitin tablet

Examples

Experimental program
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Embodiment 1 to 30

[0051] In the following examples 1-30, a glucosamine chondroitin tablet containing active peptide and organic calcium and its preparation method are provided. in,

[0052] Formula: the formula composition of the glucosamine chondroitin tablet containing active peptide and organic calcium is shown in Table 1.

[0053] Preparation method: Prepare the corresponding glucosamine chondroitin tablets containing active peptide and organic calcium according to the following method:

[0054] (1) Pass the active peptide, calcium citrate malate, diluent and dry adhesive through a 60-mesh sieve respectively, pass chondroitin sulfate sodium and lubricant through a 80-mesh sieve respectively, and pass the anti-sticking agent, film-forming agent, The plasticizer and masking agent are respectively passed through a 100-mesh sieve for subsequent use;

[0055] (2) Mix glucosamine sulfate potassium salt and adsorption hardening agent for 5 minutes at a rotating speed of 10 r / min to obtain materi...

Embodiment 31

[0071] Prescription: form with embodiment 16 prescription.

[0072] Preparation:

[0073] (1) Pass the active peptide, calcium citrate malate, sodium chondroitin sulfate, diluent, dry adhesive, and lubricant through a 40-mesh sieve respectively; Pass through 80-mesh sieve respectively, set aside;

[0074] (2) Mix glucosamine sulfate potassium salt and adsorption hardening agent for 2 minutes at a rotating speed of 10 r / min to obtain material I;

[0075] (3) Pass material I through a 50-mesh sieve, and mix for 3 minutes at a rotating speed of 20 r / min to obtain material II;

[0076] (4) Mix the sieved active peptide, calcium citrate malate, sodium chondroitin sulfate, diluent, dry adhesive, lubricant and material II at a speed of 5 r / min for 45 minutes to obtain the material III;

[0077] (5) The tablet hardness is controlled to be 80N, and the material III is pressed into tablets to obtain the material IV;

[0078] (6) Mix the anti-adhesive agent, film-forming agent, plas...

Embodiment 32

[0082] Prescription: form with embodiment 30 prescription.

[0083] Preparation method: (1) Pass the active peptide, calcium citrate malate, sodium chondroitin sulfate, diluent, dry adhesive and lubricant through an 80-mesh sieve respectively; and masking agent are respectively passed through a 400-mesh sieve for subsequent use;

[0084] (2) Mix glucosamine sulfate potassium salt and adsorption hardening agent for 8 minutes at a rotating speed of 20r / min to obtain material I;

[0085] (3) Pass material I through a 80-mesh sieve, and mix for 10 minutes at a rotating speed of 10 r / min to obtain material II;

[0086] (4) Mix the sieved active peptide, calcium citrate malate, sodium chondroitin sulfate, diluent, dry adhesive, lubricant and material II at a speed of 20r / min for 15 minutes to obtain the material III;

[0087] (5) The tablet hardness is controlled to be 250N, and material III is pressed into tablets to obtain material IV;

[0088] (6) Mix the anti-adhesive agent, f...

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Abstract

The invention provides a glucosamine chondroitin tablet containing active peptide and organic calcium and a preparation method of the glucosamine chondroitin tablet. The glucosamine chondroitin tablet comprises 50 to 250 parts of active peptide, 180 to 550 parts of calcium citrate malate, 80 to 520 parts of glucosamine potassium sulfate, 110 to 290 parts of chondroitin sulfate sodium, 10 to 90 parts of diluent, 30 to 170 parts of dry adhesive, 1 to 20 parts of adsorption hardening agent, 1 to 14 parts of lubricant, 0.05 to 3 parts of anti-sticking agent, 1 to 22 parts of film-forming agent, 0.01 to 7 parts of plasticizer and 0.05 to 5 parts of screening agent. The glucosamine chondroitin tablet disclosed by the invention is good in stability and high in calcium ion human body absorption and utilization rate, and can provide a safe and effective calcium source for patients with osteoporosis; meanwhile, damage to the tabletting mold in the production process is effectively reduced, the production and maintenance cost is reduced, dust on one side during tabletting is reduced, the product yield is increased, and the tabletting device is suitable for industrial large-scale production.

Description

technical field [0001] The invention relates to the technical field of functional foods, in particular to a glucosamine chondroitin tablet containing active peptides and organic calcium and a preparation method thereof. Background technique [0002] At present, it is known that supplementing dietary ingredients such as glucosamine, chondroitin sulfate sodium, calcium, calcium absorption promotion (CPP), and adhesion promotion (collagen peptide) is very beneficial to the alleviation and control of osteoporosis. Therefore, The compound of glucosamine and chondroitin sulfate sodium or other components has become the most widely used dietary supplement in the treatment of bone and joint diseases. [0003] However, the glucosamine products currently on the market for increasing bone density generally contain glucosamine, chondroitin sulfate, calcium carbonate and collagen as the main components. Such products have poor calcium ion release efficiency and poor stability, resulting ...

Claims

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Application Information

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IPC IPC(8): A23L33/125A23L33/18A23L33/10A23P10/28A61K9/36A61K9/32A61K31/194A61K31/7008A61K31/737A61K38/17A61K38/39A61K47/04A61K47/02A61K47/32A61K47/38A61K47/26A61P19/10
CPCA23L33/125A23L33/18A23L33/10A23P10/28A61K38/1706A61K31/7008A61K31/737A61K31/194A61K38/1709A61K38/39A61K9/2054A61K9/2027A61K9/2009A61K9/2018A61K9/2866A61K9/286A61K9/2893A61K9/2095A61P19/10A23V2002/00A61K2300/00A23V2200/306
Inventor 陆文岐伍彪常弘杰张业敏余孝云何水杰
Owner SHENZHEN TAITAI PHARMA IND
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