Small interfering RNA targeting penaeus monodon TRIM9 gene and application of small interfering RNA

A technology of penaeus monodon and small interference, applied in the field of small interference RNA, can solve problems such as outbreaks, and achieve the effects of ensuring economic benefits, inhibiting replication, and improving survival rate
CN112725338AActive Publication Date: 2021-04-30SOUTH CHINA SEA FISHERIES RES INST CHINESE ACAD OF FISHERY SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SOUTH CHINA SEA FISHERIES RES INST CHINESE ACAD OF FISHERY SCI
Publication Date
2021-04-30

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Abstract

The invention discloses a small interfering RNA targeting a penaeus monodon TRIM9 gene, wherein the small interfering RNA has a sense strand sequence of 5'-GCUCCGUUCUGACGCCGACAGACG-3' and an antisense strand sequence of 5'-CGUCUGUCGGCGUCAGAACGGAGC-3'. The invention also discloses an application of the small interfering RNA. The TRIM9-siRNA disclosed by the invention can obviously inhibit the expression of the penaeus monodon TRIM9 gene, promote the expression of various antibacterial peptide genes, inhibit the replication of vibrio parahaemolyticus in penaeus monodon, and improve the survival rate of the penaeus monodon under the infection of the vibrio parahaemolyticus.
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Description

technical field

[0001] The present invention relates to a small interfering RNA (small interfering RNA, siRNA), in particular to a small interfering RNA targeting the TRIM9 gene of Penaeus monodon. At the same time, the present invention also relates to its use in resisting Vibrio parahaemolyticus infection. Background technique

[0002] Small interfering RNA (small interfering RNA, siRNA) is a double-stranded RNA with a length of 20-25 nucleotides, which has many different uses in biology. At present, it is known that siRNA is mainly involved in the phenomenon of RNA interference (RNAi) in organisms, and regulates the expression of functional genes in a specific silencing manner. In recent years, RNA interference technology has made great progress in the treatment of bacteria, viruses and other diseases, especially in the treatment of human AIDS, hepatitis B and other diseases. The latest research shows that siRNA targeting HIV structural protein gene and long terminal re...

Claims

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