Small molecule compound for treating osteoarthritis and application of small molecule compound
A technology of small molecule compounds and osteoarthritis, applied in the field of small molecule compounds for the treatment of osteoarthritis, can solve the problem of unclear pathogenesis of KOA
Pending Publication Date: 2021-05-07
LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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Although biomechanical, metabolic, and genetic risk factors have been identified, the exact pathogenesis of KOA remains unclear, and finding targets for the prevention and treatment of KOA is a very active area of research
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[0022] Forty clean-grade 3-month-old C57BL male mice were randomly divided into Sham group, KOA group, positive control group, and notopterythol group according to body weight. The rats in the control group were intragastrically administered with the same amount of normal saline every day, and the positive control group were intragastrically administered with Mobico every day. After continuous gavage treatment for 12 weeks, the swelling degree of the knee joint and the function of joint lymphatic reflux were detected, and then the knee joint was taken to make paraffin specimens, 4 μm serial sections, and stained with Alcian blue and orange red G (ABOG) to observe tissue damage, synovial hyperplasia and Articular cartilage destruction, immunohistochemistry and immunofluorescence staining to observe cartilage COLII and MMP13, and the number of lymphatic vessels.
[0023] 4.1 ABOG staining detection of mouse joint specimens
[0024] After the mouse knee joint was collected, fix ...
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The invention relates to a small molecule compound for treating osteoarthritis. The effective component of the small molecule compound is notopterol, the small molecule compound is used as a medicine for treating osteoarthritis, and the effective action concentration of the notopterol is 5-25 [mu] M. The notopterol is mixed with pharmaceutically acceptable pharmaceutical excipients to form powder medicines, ointment, powder, injection, water aqua, enteric sustained release preparations or injections. Animal experiments prove that notopterol can reduce the OARSI score, synovial area and cartilage defect of osteoarthritis mice and relieve knee joint tissue damage and swelling of the osteoarthritis mice. The invention also discloses an application of the notopterol to preparation of medicines or health-care products for treating the osteoarthritis.
Description
technical field [0001] The invention relates to a small molecular compound for treating osteoarthritis, and proposes the application of the small molecular compound in preparing various forms of medicines or health food for preventing and treating osteoarthritis. Background technique [0002] Osteoarthritis (OA) is a common chronic degenerative disease of weight-bearing joints in clinical practice. , swelling, and joint deformity are the main clinical manifestations of total joint disease. The degeneration of articular cartilage in OA is irreversible, and there is still a lack of effective treatment drugs. High tibial osteotomy and joint replacement surgery are currently recognized as effective treatments for KOA. Although biomechanical, metabolic, and genetic risk factors have been discovered, the exact pathogenesis of KOA remains unclear, and finding targets for the prevention and treatment of KOA is a very active research area. [0003] In recent years, our research has...
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IPC IPC(8): A61K31/366A61P19/08A61P19/02A61P29/00A23L33/105
CPCA61K31/366A61P19/08A61P19/02A61P29/00A23L33/105A23V2002/00A23V2200/30A23V2250/21
Inventor 徐浩王拥军梁倩倩易南星施杞王琼张霆杨燕萍常君丽卢盛
Owner LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE