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Tumor targeting carrier for low-dose radiotherapy, preparation method of tumor targeting drug and tumor targeting drug

A tumor-targeted and radiotherapy technology, applied in the preparation of tumor-targeted carriers and the field of tumor-targeted drugs, can solve the problems of low reflex sensitivity of tumor cells and poor tumor targeting, so as to improve the curative effect and enhance the sensitivity degree of effect

Pending Publication Date: 2021-05-07
SHENZHEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In view of this, the present invention provides a tumor-targeting carrier for low-dose radiation therapy, and the present invention also provides a preparation method for the tumor-targeting carrier for low-dose radiation therapy, and the present invention also provides A drug for low-dose radiotherapy to solve the defects of poor tumor targeting and low tumor cell reflex sensitivity in existing radiotherapy

Method used

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  • Tumor targeting carrier for low-dose radiotherapy, preparation method of tumor targeting drug and tumor targeting drug
  • Tumor targeting carrier for low-dose radiotherapy, preparation method of tumor targeting drug and tumor targeting drug
  • Tumor targeting carrier for low-dose radiotherapy, preparation method of tumor targeting drug and tumor targeting drug

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preparation example Construction

[0035] In the second aspect, the present invention also provides a method for preparing a tumor-targeting carrier for low-dose radiation therapy, comprising the following steps:

[0036] Anaerobic bacteria and black phosphorus quantum dots are provided, the anaerobic bacteria are subjected to surface ammonification treatment, and the surface ammonified anaerobic bacteria are mixed with black phosphorus quantum dots so that the black phosphorus quantum dots are adsorbed on the anaerobic bacteria, Tumor-targeting vectors for low-dose radiation therapy were produced.

[0037] Preferably, the preparation method of the black phosphorus quantum dots is as follows: black phosphorus powder is provided and the black phosphorus powder is dissolved in N-methylpyrrolidone, and the N-methylpyrrolidone dispersion of the black phosphorus powder is sequentially subjected to probe ultrasonication and water bath Ultrasound, the dispersion system after ultrasonication in the water bath is firstl...

Embodiment 1

[0052] Such as figure 1 Shown, the preparation method of the tumor-targeted carrier for low-dose radiotherapy comprises the following steps:

[0053] (1) Preparation of black phosphorus quantum dots (BPQD) by ultrasonic exfoliation

[0054] Add 25mg of BP powder into a 50ml sealed conical tube containing 25ml NMP (N-methylpyrrolidone), and use a pulse probe to ultrasonicate for 3h at a power of 1200W, the ultrasonic frequency is set to 22kHz, and the pulse setting of the pulse probe ultrasonic For work 2s, interval 4s. After the probe sonication, the dispersion after the pulse probe sonication was transferred to the water bath ultrasonic to continue the ultrasonic dispersion. The power of the water bath sonication was 300W, the time of the water bath sonication was 10h, and the temperature of the water bath sonication was kept below 4°C. The dispersion system after the two-step ultrasonic dispersion was first centrifuged at 7000 rpm for 20 minutes, and the supernatant contai...

Embodiment 2

[0060] A method for preparing a tumor-targeted carrier for low-dose radiotherapy, comprising the following steps:

[0061] (1) Preparation of black phosphorus quantum dots (BPQD) by ultrasonic exfoliation

[0062] Add 6.25mg of BP powder into a 50ml sealed conical tube containing 25ml of NMP (N-methylpyrrolidone), and use a pulse probe to ultrasonicate for 1h at a power of 2400W, set the ultrasonic frequency to 25kHz, and pulse the ultrasonic pulse of the pulse probe Set to work 2s, interval 4s. After the probe sonication, the dispersion after the pulse probe sonication was transferred to the water bath ultrasonic to continue the ultrasonic dispersion. The power of the water bath ultrasonic was 150W, the time of the water bath ultrasonic was 20h, and the temperature of the water bath ultrasonic was kept below 2°C. The dispersion system after the two-step ultrasonic dispersion was first centrifuged at 8000rpm for 10 minutes, and the supernatant containing black phosphorus quan...

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Abstract

The invention provides a tumor targeting carrier for low-dose radiotherapy. The tumor targeting carrier comprises anaerobic bacteria and black phosphorus quantum dots adsorbed on the anaerobic bacteria. The invention further provides a preparation method of the tumor targeting carrier for low-dose radiotherapy and a medicine for low-dose radiotherapy. The tumor targeting carrier for low-dose radiotherapy has anaerobic bacteria, and by means of the anaerobic tropism of the anaerobic bacteria, the tumor targeting carrier can be accurately positioned to tumor cells. The tumor targeting carrier for low-dose radiotherapy adopts the black phosphorus quantum dots (BPQD), has high photothermal conversion efficiency, and achieves the effect of targeted therapy of hypoxia tumor cells through the photothermal effect; and on the other hand, the black phosphorus quantum dots (BPQD) further have a radiation therapy sensitization effect, and the black phosphorus quantum dots and the tumor targeting carrier cooperate to significantly improve the curative effect of radiation therapy, so that low-dose tumor treatment is realized, and huge clinical application potential is achieved.

Description

technical field [0001] The present invention relates to the technical field of anti-tumor bio-nano medicine, in particular to a tumor-targeting carrier for low-dose radiation therapy, and also relates to a method for preparing a tumor-targeting carrier for low-dose radiation therapy. The present invention also relates to a tumor-targeting drug comprising the aforementioned tumor-targeting carrier for low-dose radiotherapy. Background technique [0002] Radiation therapy (RT), one of the three main approaches used to treat cancer, relies on the targeted delivery of high-energy X-rays or γ-rays to induce DNA damage and tumor cell apoptosis, thereby promoting tumor ablation. Although RT is a common treatment modality, RT is accompanied by severe side effects, and its efficacy may be limited by oxygen deficiency within the tumor microenvironment (TME), resulting in incomplete eradication of target tumors. At present, many clinical trials try to overcome the oxygen dependence of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/69A61K33/42A61P35/00
CPCA61K41/0038A61K41/0052A61K47/6901A61K33/42A61P35/00A61K2300/00Y02A50/30
Inventor 张晗朵燕红张家宜
Owner SHENZHEN UNIV
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