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Preparation method of asiaticoside extract and application of asiaticoside extract in cosmetics

A technology of asiaticoside and extract, which is applied in the field of preparation of asiaticoside extract, can solve the problems of different biological activities and achieve the effect of easy operation

Inactive Publication Date: 2021-05-11
广州贝塔健康生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although their structures are extremely similar, their biological activities are not the same. Among them, madecassoside has anti-inflammatory and therapeutic activities such as rheumatoid arthritis; asiaticoside can promote wound healing, and has obvious effects on burn scars. Healing effect, often used as a symbolic component to evaluate the pharmacological activity of Centella asiatica; due to the difficulty of obtaining pure asiaticoside-B, there has been no report on its pharmacological activity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A preparation method of asiaticoside extract, specifically comprising the following steps:

[0025] (1) Grind Centella asiatica with high asiaticoside content into powder and disperse into 8 times the weight of acetone, stir and mix for 15 minutes, filter and wash twice with sufficient ethanol to obtain a solid and a filtrate;

[0026] (2) Disperse the solid matter obtained in step (1) in 10 times the weight of water at 50°C for reflux extraction 3 times, each time for 1 hour, extract and filter to obtain a filtrate, and combine the filtrates to obtain a powder after spray drying;

[0027] (3) Disperse the powder obtained in step (2) in 3 times the weight of methyl isobutyl ketone, stir and mix for 20 min and then filter to obtain solids and filtrate, and the filtrate is rotary evaporated to recover methyl isobutyl ketone;

[0028] (4) Dissolve the solid substance 2 obtained in step (3) in 3 times the weight of methanol at 55° C., filter, cool and stand for 60 minutes t...

Embodiment 2

[0033] A preparation method of asiaticoside extract, specifically comprising the following steps:

[0034] (1) Grind Centella asiatica with low asiaticoside content into powder and disperse into 6 times the weight of acetone, stir and mix for 20 minutes, filter and wash with sufficient ethanol for 3 times to obtain solids and filtrate;

[0035] (2) Disperse the solid matter obtained in step (1) in 10 times the weight of water at 450°C for reflux extraction 4 times, each time for 1.5 hours, extract and filter to obtain the filtrate, and combine the filtrate to obtain a powder after spray drying;

[0036] (3) Disperse the powder obtained in step (2) in 3 times the weight of methyl isobutyl ketone, stir and mix for 20 min and then filter to obtain solids and filtrate, and the filtrate is rotary evaporated to recover methyl isobutyl ketone;

[0037] (4) Dissolve the solid substance 2 obtained in step (3) in 3 times the weight of methanol at 60° C., filter, cool and stand for 60 mi...

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PUM

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Abstract

The invention discloses a preparation method of an asiaticoside extract and application of the asiaticoside extract in cosmetics, firstly, ground centella asiatica is subjected to preliminary impurity removal, then extraction is performed by using water as an extracting solution by utilizing the hydrophilicity of asiaticoside, and then multi-step impurity removal and purification are performed to obtain high-yield and high-purity asiaticoside. Moreover, the method is simple and convenient in process, few in used harmful chemical agents, complete in solvent recovery and free of environmental pollution, and most importantly, the method is suitable for extraction of asiaticoside in any type of centella asiatica, has universality and is suitable for industrial production and application.

Description

technical field [0001] The invention relates to the technical field of extracting plant components, in particular to a preparation method of asiaticoside extract and its application in cosmetics. Background technique [0002] Centella asiatica (L.) Urban, also known as mint, ground grass, etc., is a plant of the genus Centella asiatica in the umbelliferous family. It is widely distributed in South Africa, India and south of the Yangtze River Basin in my country. It is a traditional Chinese herbal medicine. . According to research reports, Centella asiatica has various physiological activities such as anti-inflammation, enhancing memory, promoting collagen synthesis, anti-depression and anti-cancer, and has a wide range of applications in the preparation of medicines and cosmetics. [0003] The chemical composition of Centella asiatica is complex, mainly including triterpenoids, flavonoids, volatile oils, polyynenes and so on. At present, it is believed that the main active ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61Q19/00
CPCA61K8/9789A61Q19/00A61K2800/10A61K2800/805
Inventor 姚灿辉陆青蓉
Owner 广州贝塔健康生物科技有限公司
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