8 results about "Asialoganglioside" patented technology

The application belongs to the field of natural product extraction and cosmetic raw materials, and discloses a preparation method and application of a composition containing asiaticoside-paeoniflorin, which comprises two key and functionally different stages: ① extraction stage: using asiaticoside as an extraction aid and using propylene glycol as a complex medium, efficiently dissolving and forming an "asiaticoside-paeoniflorin" supramolecular complex; ② complexing and stabilizing stage: using glycerol as a stabilizer to maintain the long-term kinetic stability of the formed supramolecular complex and prevent its dissociation and aggregation. The method solves the technical problem that the extraction rate and stability of paeoniflorin are difficult to be considered simultaneously in the field by functional division of extraction and stabilization, and the composition containing asiaticoside-paeoniflorin obtained finally has excellent soothing performance, not only rapid effect, but also persistent and stable soothing protection effect, which can effectively resist and repair the influence of external stimulation on the skin.

The application discloses an anti-wrinkle and firming composition suitable for multiple skin types and a preparation method and application thereof, and belongs to the technical field of cosmetics. The composition contains, in mass parts, 2.5-9.5 parts of an active functional component, 5-10 parts of a targeted delivery carrier system and cosmetically acceptable adjuvants. The active functional component is composed of ginsenoside Rb1, green tea extract-white resveratrol compound and asiaticoside-dipotassium glycyrrhizinate compound, and the targeted delivery carrier system is a transdermal peptide modified liposome and a natural nano-structured lipid carrier. The application constructs a double-targeted delivery system according to different skin aging mechanisms and skin characteristics, realizes single formula adaptation to multiple skin types, improves the transdermal efficiency of active ingredients and the targeted enrichment effect on the dermis, has no carrier residue, and multiple components synergistically play the effects of anti-wrinkle and firming, soothing and protection, is safe, and can be widely applied to the preparation of anti-aging skin care products.

The present application provides a kind of pharmaceutical composition for vulvar sclerosing lichen and its preparation method, the pharmaceutical composition includes active ingredient and pharmaceutically acceptable vulva local administration adjuvant, active ingredient is made of 0.005-0.02 parts of mometasone furoate, 0.05-0.3 parts of calcineurin inhibitor, 0.5-2 parts of paeoniflorin, 0.8-3 parts of asiaticoside, 0.3-1.5 parts of recombinant collagen, 0.2-1 part of ginkgolide B.The present application is aimed at the core pathogenesis of disease, constructs multi-target whole course of disease synergistic therapy system, can realize anti-inflammatory regulation, anti-fibrosis, basement membrane repair, microcirculation improvement simultaneously, low-dose strong effect, greatly reduce side effect and recurrence rate;Liposome targeted delivery technology is used, the stability of active ingredient is guaranteed, process controllable adaptation industrialization production, and clinical application prospect is wide.

This invention belongs to the field of natural product extraction and cosmetic raw materials, and discloses a method for preparing a composition containing asiaticoside-paeoniflorin and its application. The preparation method includes two key and functionally distinct stages: ① Extraction stage: using asiaticoside as an extraction aid and propylene glycol as a composite medium, efficiently dissolving and forming a supramolecular complex of "asiaticoside-paeoniflorin"; ② Complex stabilization stage: using glycerol as a stabilizer to maintain the long-term kinetic stability of the formed supramolecular complex and prevent its dissociation and aggregation. This method, through the functional division of labor between extraction and stabilization, synergistically solves the long-standing technical problem in the field of balancing the extraction rate and stability of paeoniflorin. Furthermore, the composition containing asiaticoside-paeoniflorin obtained by this invention possesses excellent soothing properties, not only acting rapidly but also providing long-lasting and stable soothing protection, effectively combating and repairing the effects of external stimuli on the skin.

The application discloses a pH-sensitive asiaticoside drug-loaded micelle as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations. The drug-loaded micelle takes mPEG-PLGA-PHis triblock copolymer as a carrier, realizes high drug loading, high encapsulation efficiency and pH 5.5 precise response drug release by limiting the molar ratio of lactic acid and glycolic acid to 70:30-80:20, the specific molecular weight interval of each block and the mass ratio, the micelle particle size is 30-120 nm, the structure is stable in a neutral environment, and the drug is quickly released by depolymerization in an inflammatory micro-acid environment. The preparation adopts a film dispersion-dialysis process, has low organic solvent residue, uniform particle size, good batch repeatability and is suitable for industrial production. The drug-loaded micelle can be made into gel, cream and other external preparations, is used for skin inflammation repair, wound healing, scar lightening and post-medical beauty repair and has good clinical application and industrial value.

This invention discloses a composition with whitening and anti-wrinkle functions, its preparation method, and its application. The composition combines Asian birch sap and Rosa damascena flower water to replenish basic moisture and nutrients to the skin, soothing discomfort. Niacinamide, α-arbutin, 3-o-ethyl ascorbic acid, 4-butylresorcinol, and glutathione work synergistically to achieve whitening effects. Acetyl hexapeptide-8 reduces expression line formation by inhibiting neurotransmitter release, and, combined with palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, and hydroxypropyl tetrahydropyranotriol, reduces fine lines, achieving anti-wrinkle and firming effects. Hyaluronic acid, sodium hyaluronate, hydrolyzed hyaluronic acid, sodium hyaluronate crosspolymer, and acetylated sodium hyaluronate form a multi-moisturizing system, combined with butylene glycol, trehalose, betaine, and glycerin to lock in skin moisture. Centella asiatica extract, asiaticoside, asiaticoside, Scutellaria baicalensis root extract, Paeonia lactiflora root extract, and other plant extracts soothe the skin.

This invention discloses a stable synergistic composition based on asiaticoside and ergothioneine, which mainly comprises asiaticoside and ergothioneine, wherein the weight ratio of asiaticoside to ergothioneine is 0.5-5:1-8, and the content of asiaticoside in the composition is 0.05-2 wt%. This invention also discloses the application of asiaticoside in inhibiting the photodegradation of ergothioneine, the antioxidant use of the composition based on asiaticoside and ergothioneine, the use of the composition based on asiaticoside and ergothioneine as an FLG gene expression promoter, or a LOR gene expression promoter, or a Claudin-1 gene expression promoter, and the use of this composition in topical skin preparations.

The present invention relates to a pharmaceutical composition comprising a TGF-beta receptor inhibitor selected from the group consisting of Galunisertib (LY2157299), Vactosertib (EW-7197), Itacnosertib (TP-0184), and Repsox (E-616452), and at least one pharmaceutically acceptable carrier, excipient and / or diluent, for use in the treatment of a fibrotic lung disease, in particular idiopathic pulmonary fibrosis (IPF). Preferably, the at least one excipient of the pharmaceutical composition for use according to the invention comprises triterpenoid saponin molecules, more preferably asiaticoside and / or glycyrrhizin molecules.