39 results about "Asialoganglioside" patented technology

The invention discloses a compound with a wrinkle removing function. The compound comprises triterpenoid saponin and triterpene acid, wherein the triterpenoid saponin and the triterpene acid are active ingredients from centella. The triterpenoid saponin comprises one or two of asiaticoside and hydroxy asiaticoside, and the triterpene acid comprises one or two of asiatic acid and madasiatic acid. By compounding any one or two of the triterpenoid saponin with any one or two of the triterpene acid, human skin fibroblast secretes type I collagen, and the like can be remarkably improved, the obvious effect of aging skin regeneration is realized, and the compound can be used for the development of wrinkle removing cosmetics.

The invention provides camellia extract-containing gel with an after-sun repair effect and a preparation method thereof. The gel is prepared from the following components in percentage by weight: 5 to20 percent of camellia extract inclusion; 10 to 40 percent of aloe leaf juice; 0.1 to 1 percent of asiaticoside; 0.1 to 1 percent of radix sophorae flavescentis extract; 0.1 to 1 percent of beta-glucan; 0.01 to 0.2 percent of dipotassium glycyrrhizinate; 0.01 to 0.1 percent of sodium hyaluronate; 0.1 to 1 percent of a thickening agent; 0.1 to 1 percent of a preservative; and the balanced of deionized water. The gel with the after-sun repair effect also comprises a pH regulator which is added to adjust the pH value to be neutral. According to the invention, a plurality of functional componentsare compounded according to an optimal ratio, so that the gel can effectively relieve skin inflammation, repair skin barrier, supplement water and preserve moisture, and can effectively relieve skindiscomfort caused by strong sunlight irradiation.

The invention discloses an anti-inflammatory composition as well as a preparation method and application thereof. The anti-inflammatory composition is prepared from the following components: magnololand asiaticoside, wherein the concentration of asiaticoside is 10 uM or 2.5 uM. The preparation method of the anti-inflammatory composition comprises the steps that magnolol and asiaticoside are prepared to be mother liquid with the concentration being 20 mM by using solvents, then a DMEM (dulbecco modified eagle medium) culture medium is adopted to dilute the asiaticoside mother liquid to be 10 uM, the DMEM culture medium is adopted to dilute the magnolol to be 10 uM, 5 uM or 2.5 uM; and finally the diluted magnolol mother liquid and asiaticoside mother liquid are mixed to be uniform, and theanti-inflammatory composition is obtained. The invention discovers that asiaticoside can effectively enhance the anti-inflammatory activity of low-concentration magnolol (10, 5 and 2.5 uM), magnololand asiaticoside have the synergistic effect, and the effect can be better when magnolol and asiaticoside are matched at the ratio of 1 to 1.

The invention discloses a medical composition. The medical composition is a preparation prepared from the following components in parts by weight: 10 to 100 parts of nano-silver, 30 to 80 parts of hydrolyzed collagen, 10 to 50 parts of bletilla striata gelatin and 0.5 to 3 parts of asiaticoside. The invention further discloses a preparation method and application of the medical composition. The medical composition disclosed by the invention can be used for rapidly reducing a wound area of damaged skin, remarkably shortening scabbing, scab falling and wound healing time and accelerating skin wound healing speed; the medical composition can be used for effectively repairing the damaged skin and has relatively strong actual application value.

The invention relates to a medicinal preparation for promoting healing of body surface injury and a method for preparing the medicinal preparation. Silver sulfadiazine (a), pain killers (b), asiaticoside (c) and other pharmaceutically acceptable carriers (d) are compatible with one another according to suitable proportions to obtain the medicinal preparation. The medicinal preparation and the method have the advantages that the medicinal preparation has double synergistic antibacterial and pain alleviating functions, accordingly, healing of wound surfaces can be promoted, epidermis hyperpigmentation due to the silver sulfadiazine can be prevented, and scar can be reduced; the shortcomings of poor hydrophilicity after existing pain killers and existing silver sulfadiazine are directly compatible with one another and easiness in volatilizing moisture in wound surfaces can be overcome.

The invention discloses a medicine composition for preventing and treating diabetes mellitus and application of the medicine composition. The medicine composition comprises a component (i) rebamipideand / or an analog thereof, and a component (ii) asiaticoside and / or an analog thereof. The medicine composition disclosed by the invention is capable of remarkably reducing the blood sugar and the incidence rate of an NOD (no obesity diabetes) mouse, improving the response capability to a glucose load, relieving pancreas islet inflammation, inhibiting expression of a Th1 type cell factor, promotingexpression of a Th2 type cell factor, reducing the death rate and taking functions of preventing and treating diabetes mellitus into play, and has wide application prospects.

The invention discloses a skin care product for improving skin anti-sensitivity and repairing ability, which is made of the following raw materials: 30-90 parts of pachysan, 0.1-10 parts of glycerin, 0.1-5 parts of trimethylglycine, and 0.01 parts of baicalin -3 parts, glycyrrhizin 0.01-5 parts, asiaticoside 0.01-5 parts, deionized water 0-69.77 parts. The present invention selects amino acid moisturizer with natural structure and naturally sourced polysaccharide compound, which can not only rapidly improve the water retention capacity of the skin, firmly lock the water, stimulate cell vitality, but also improve the skin's response to baicalin and glycyrrhizin. , asiaticoside and other natural anti-inflammatory active ingredients, so as to play anti-inflammatory and anti-itching effects, improve skin anti-sensitivity and repair ability; the formula is simple, and the raw materials are almost all derived from plant ingredients, avoiding the stimulation of chemical synthetic ingredients , can effectively improve the redness, swelling, itching, peeling and other symptoms of sensitive skin, make the skin feel comfortable and safe and re-establish the skin barrier function; the preparation process is simple and the cost is low.

The invention relates to a plant active component composition with slow anti-allergic action. The plant active component composition is mainly prepared from natural plant active components: 0.1-5wt% of glycyrrhetinic acid, 0.05-1wt% of apigenin, 0.05-1% of table gallic catechin gallic acid ester, 0.1-3wt% of asiaticoside, 0.1-5wt% of baicalin and 0.1-10wt% of fucus serratus extract. The composition is used for preparing cosmetics or personal care products with a plurality of effects of resisting skin allergy, diminishing inflammation, relieving itching, resisting oxidation, moisturizing and the like. The composition is safe and free of toxic and side effects, and can be compounded with a plurality of components, sensitive skin and dry skin are effectively improved, and the barrier function of the skin is reinforced.

The invention discloses a medicine composition for treating acne and an application thereof. The medicine composition is prepared by combining the following components: asiaticoside, osthole, cryptotanshinone, paeonol and chlorogenic acid, wherein the weight ratio of asiaticoside to osthole to cryptotanshinone to paeonol to chlorogenic acid is (3-6) to (3-6) to (2-4) to (2-4) to (3-6). The medicine composition is applied to preparation of a medicine preparation for skin or a cosmetic. The medicine composition has the effect of treating acne, has good effects and is safe and reliable.

The invention belongs to the field of medical preparations, and in particular relates to a liquid wound dressing and a preparation method thereof. The liquid wound dressing of the present invention comprises the following components in mass percentage: 52.29% to 78% antibacterial liquid, 8.51% to 29.5% healing liquid and 10% % to 20% film-forming agent; based on the mass percentage of the liquid wound dressing, the healing liquid contains 0.01% to 0.5% hyaluronic acid and 0.5% to 3% asiaticoside; the antibacterial liquid contains 0.09% to 0.9% Antimicrobial peptides and 0.9% to 9% chitosan. The liquid wound dressing of the invention has good air permeability and water resistance, has a delicate smell, is easy to peel off after film formation, has short film formation time, and has excellent antibacterial and wound healing effects.

The invention provides an anti-aging composition and application thereof, and particularly relates to the anti-aging composition having an effect of stabilizing adhesion between epidermis and dermis as well as application thereof. The composition is prepared from the following various components in percentage by weight: 20 to 30 percent of peony extract, 5 to 15 percent of oat polypeptide, 5 to 10percent of asiaticoside, 5 to 15 percent of soy isoflavone, 5 to 15 percent of ormosia henryi Prain bark extract, 1 to 5 percent of acetyl hydroxyproline, 10 to 20 percent of ginseng extract, and 10to 20 percent of cordyceps sinensis extract. The anti-aging composition disclosed by the invention has the following beneficial effects that the anti-aging composition has more action targets, promotion on expression of collagen protein is achieved, the stable adhesion between the epidermis and the dermis also can be maintained; the collaborative ability is strong, the effect of the composition exceeds the effect of a single raw material; the action effect is mild and irritability is low.

A kind of spinning, which is made by blending PLGA, PEO and asiaticoside through stable jet electrospinning technology, and has the same orientation. Wherein, the weight ratio of PLGA to PEO is 4:1, and the dosage of asiaticoside is 10wt% of PLGA. The spinning of the present invention has significantly improved hydrophilicity, has the effect of regulating macrophage phenotype transformation and anti-inflammation in vivo, and can be used to prepare medicines or medical devices for regulating macrophage phenotype transformation and anti-inflammation in vivo (such as: stand).

The invention discloses a medicine composition for preventing and treating diabetes mellitus and application of the medicine composition. The medicine composition comprises a component (i) rebamipideand / or an analog thereof, and a component (ii) asiaticoside and / or an analog thereof. The medicine composition disclosed by the invention is capable of remarkably reducing the blood sugar and the incidence rate of an NOD (no obesity diabetes) mouse, improving the response capability to a glucose load, relieving pancreas islet inflammation, inhibiting expression of a Th1 type cell factor, promotingexpression of a Th2 type cell factor, reducing the death rate and taking functions of preventing and treating diabetes mellitus into play, and has wide application prospects.

The invention discloses asiaticoside-chitosan-sodium alginate microspheres, a preparation method and application thereof, and belongs to the technical field of biomedical materials. The microspheres are prepared by an emulsification cross-linking method and finally obtained by freeze-drying. The preparation method comprises the following steps: 1) preparing sodium alginate solution and asiaticoside-chitosan acetic acid solution respectively; 2) slowly and uniformly adding sodium alginate solution to the oil phase, stirring at high speed to form colostrum; 3) ) Slowly and evenly add the asiaticoside-chitosan acetic acid solution to the colostrum, stir, and fully emulsify; 4) Slowly and evenly add the glyceraldehyde solution to cross-link and solidify, centrifuge, and the precipitate is washed with petroleum ether successively. washing, washing with absolute ethanol, and vacuum freeze-drying to obtain light yellow powder of asiaticoside-sodium alginate-chitosan microspheres.

The invention belongs to the technical field of medicine, in particular, it relates to an HPLC characteristic spectrum of Sanjin preparation and a construction method thereof. The HPLC characteristic spectrum includes 9 characteristic peaks, wherein No. 6 peak is the asiaticoside reference peak, and the relative retention times of the other 8 characteristic peaks are: No. 1 peak 0.41, No. 2 peak 0.53, No. 3 peak 0.13, Peak No. 4 is 0.12, Peak No. 5 is 0.26, Peak No. 7 is 0.14, Peak No. 8 is 0.13, and Peak No. 9 is 0.12. The present invention establishes the characteristic map of n-butanol part of Sanjin tablet for the first time, which can synchronously track and detect multiple main components of the 4 flavors of the prescription under simple conditions, comprehensively improve the quality control standard of Sanjin preparation, and enhance the core competitiveness of the product. Lay a solid foundation to ensure the product quality and clinical efficacy of Sanjin Tablets are stable. In addition, the establishment method of the HPLC characteristic map has strong operability and good reproducibility, which provides a scientific basis for better controlling the quality of Sanjin preparations.

The invention belongs to the technical field of make-ups, and particularly relates to an acne removing preparation. The acne removing preparation is prepared from the following components in parts byweight: 1-3 parts of plant oil control factor, 0.5-2 parts of carboxymethyl yeast beta-glucan, 3-10 parts of acne bane, 0.2-1 part of asiaticoside, 0.05-0.2 part of dipotassium glycyrrhizinate and 1-6parts of folium / caulis myrothamni flabellifoliae extract. The preparation has a fast significant acne removing effect, a scar removing effect, an effect of significantly removing active oxygen in neutrophil, a bacteriostasis effect, effects of enhancing cell activity and promoting TIMP-1 factor secretion, and more uncommonly, a very good effect of repairing scars left in a disease course within one year.

The invention discloses for the first time the application of asiaticoside in the preparation of medicaments for treating skin cancer. The results of the DMBA / TPA two-step chemically induced mouse skin cancer model show that the therapeutic effect of asiaticoside on skin cancer is significantly better than that of the drugs used to treat scars, other AMPK agonists, clinical drugs for other cancers, and similar structures. medicine. The present invention provides a new drug choice for clinical treatment of skin cancer.