39 results about "Asialoganglioside" patented technology

An anti-aging composition comprising: (i) at least one biomimetic oligopeptide having a sequence of 20 amino acids or less; (ii) at least one lipoaminoacid; (iii) at least one pentacyclic triterpenoid selected from the group consisting of asiaticoside, madecassic acid, asiatic acid and madecassoside; (iv) at least one antioxidant; and (v) tetrahydropiperine; a kit comprising such composition and a method of use.

The invention discloses a compound with a wrinkle removing function. The compound comprises triterpenoid saponin and triterpene acid, wherein the triterpenoid saponin and the triterpene acid are active ingredients from centella. The triterpenoid saponin comprises one or two of asiaticoside and hydroxy asiaticoside, and the triterpene acid comprises one or two of asiatic acid and madasiatic acid. By compounding any one or two of the triterpenoid saponin with any one or two of the triterpene acid, human skin fibroblast secretes type I collagen, and the like can be remarkably improved, the obvious effect of aging skin regeneration is realized, and the compound can be used for the development of wrinkle removing cosmetics.

The invention provides camellia extract-containing gel with an after-sun repair effect and a preparation method thereof. The gel is prepared from the following components in percentage by weight: 5 to20 percent of camellia extract inclusion; 10 to 40 percent of aloe leaf juice; 0.1 to 1 percent of asiaticoside; 0.1 to 1 percent of radix sophorae flavescentis extract; 0.1 to 1 percent of beta-glucan; 0.01 to 0.2 percent of dipotassium glycyrrhizinate; 0.01 to 0.1 percent of sodium hyaluronate; 0.1 to 1 percent of a thickening agent; 0.1 to 1 percent of a preservative; and the balanced of deionized water. The gel with the after-sun repair effect also comprises a pH regulator which is added to adjust the pH value to be neutral. According to the invention, a plurality of functional componentsare compounded according to an optimal ratio, so that the gel can effectively relieve skin inflammation, repair skin barrier, supplement water and preserve moisture, and can effectively relieve skindiscomfort caused by strong sunlight irradiation.

The invention discloses an anti-allergy repairing skin care preparation. The preparation contains high-content active ingredients such as phytosterol oleate and asiaticoside, so that the skin care preparation is enabled to have the effects of resisting allergy, repairing and the like. Experiments show that the prepared skin care preparation has good stability and has a good repairing effect on skin cells.

The invention relates to a method for extracting asiaticoside from centella. The method for extracting the asiaticoside from the centella comprises the following processing steps: smashing raw materials, sieving by adopting a sieve with 80 meshes, fermenting by adopting compound enzyme, adding 50-60% ethyl alcohol with the amount being 5-8 times that of the raw material into the fermented raw material, placing the obtained mixture into a double-frequency ultrasonic extractor, extracting at the temperature of 50-60 DEG C for 60-90 minutes with ultrasonic frequencies being 40KHz and 80KHz and power being 400-600W, filtering, concentrating, carrying out petroleum ether-water extraction, taking a lower layer, and carrying out separation and purification by virtue of an alumina column, concentration and recrystallization, so that the asiaticoside is obtained. The method for extracting the asiaticoside from the centella is short in extraction time, high in yield, easy in operation, safe and reliable, high in efficiency and energy-saving and is applicable to industrial production.

The invention provides a factor composition and composite freeze-dried powder for promoting skin cell growth and a skin care product. The factor composition for promoting skin cell growth comprises EGF, bFGF and KGF; the composite freeze-dried powder for promoting skin cell growth is prepared from, by weight, 0.0003-0.0018% of the factor composition for promoting skin cell growth, 0.1-5% of asiaticoside, 5-28% of freeze-drying protecting agent and the balance water. By the adoption of the technical scheme, the three cell growth factors serve as ingredients for achieving main effects, and can achieve a synergistic effect to well promote growth of human body skin cells and improve the skin of people; through the freeze-drying process, bioactivity of the cell growth factors can be effectively guaranteed; the obtained skin care product has multiple effects and can comprehensively improve the skin of people.

The invention discloses a multi-effect moisturizing skin care mask, which is prepared from the following raw materials in parts by weight: 5-11 parts of radix angelicae, 3-9 parts of semen coicis, 4-8 parts of L-vitamin C, 3-9 parts of isoimperatorin, 4-7 parts of asiaticoside, 3-8 parts of polydimethylsiloxane, 2-7 parts of a rose extracting solution, 2-6 parts of poria cocos, 3-5 parts of lack soya bean, 1-4 parts of black rice, 3-5 parts of hyaluronic acid, 2-8 parts of banana juice, 5-9 parts of a cucumber extracting solution and 4-6 parts of a lemon extracting solution. The multi-effect moisturizing skin care mask has the beneficial effects that the multi-effect moisturizing skin care mask is capable of effectively moisturizing and locking water, and enhancing the elasticity of the skin, so that the skin is smooth and tight.

The invention, which belongs to the related technical field of skin care products, discloses skin care serum containing stem cell active factors and application thereof. The skin care serum comprisesthe following components, by weight: 10 to 20 parts of a stem cell active factor extracting solution, 0.08 to 0.2 part of silk protein, 0.2 to 0.6 part of asiaticoside, 1 to 2 parts of yeast extract,0.2 to 2 parts of allantoin, 0.05 to 2 parts of tocopherol, 5 to 8 parts of squalane, 0.3 to 1 part of olive oil, .5 to 0.8 part of EDTA-2Na, 0.05 to 0.2 part of triethanolamine, 0.6 to 3 parts of polyglutamic acid, 0.05 to 0.2 part of vitamin C, 5 to 10 parts of glycerol and 80 to 100 parts of water. According to the invention, a large number of bioactive factors beneficial to skin regeneration and repair, especially stem cell active factors, are contained in the formula, so that skin self-renewal and regeneration are promoted and the striae gravidarum repair effect is enhanced.

The invention provides a composition for improving scar hyperplasia and hyperpigmentation in a skin repair process. The composition comprises the following raw materials: asiaticoside, heparin sodium, allantoin and indispensable auxiliary materials, and the composition further comprises the following raw materials in parts by weight: 0.03-0.5 part of clostridium histolyticum collagenase. By adopting the composition for improving the scar hyperplasia and hyperpigmentation in the skin repair process, scar tissue can be quickly softened, the drug can be quickly absorbed under the condition of realizing quick application operation of the drug, and acne pits and depression scars can also be improved.

The invention discloses an anti-inflammatory composition as well as a preparation method and application thereof. The anti-inflammatory composition is prepared from the following components: magnololand asiaticoside, wherein the concentration of asiaticoside is 10 uM or 2.5 uM. The preparation method of the anti-inflammatory composition comprises the steps that magnolol and asiaticoside are prepared to be mother liquid with the concentration being 20 mM by using solvents, then a DMEM (dulbecco modified eagle medium) culture medium is adopted to dilute the asiaticoside mother liquid to be 10 uM, the DMEM culture medium is adopted to dilute the magnolol to be 10 uM, 5 uM or 2.5 uM; and finally the diluted magnolol mother liquid and asiaticoside mother liquid are mixed to be uniform, and theanti-inflammatory composition is obtained. The invention discovers that asiaticoside can effectively enhance the anti-inflammatory activity of low-concentration magnolol (10, 5 and 2.5 uM), magnololand asiaticoside have the synergistic effect, and the effect can be better when magnolol and asiaticoside are matched at the ratio of 1 to 1.

The invention discloses a preparation method of an asiaticoside extract and application of the asiaticoside extract in cosmetics, firstly, ground centella asiatica is subjected to preliminary impurity removal, then extraction is performed by using water as an extracting solution by utilizing the hydrophilicity of asiaticoside, and then multi-step impurity removal and purification are performed to obtain high-yield and high-purity asiaticoside. Moreover, the method is simple and convenient in process, few in used harmful chemical agents, complete in solvent recovery and free of environmental pollution, and most importantly, the method is suitable for extraction of asiaticoside in any type of centella asiatica, has universality and is suitable for industrial production and application.

The invention discloses a medical composition. The medical composition is a preparation prepared from the following components in parts by weight: 10 to 100 parts of nano-silver, 30 to 80 parts of hydrolyzed collagen, 10 to 50 parts of bletilla striata gelatin and 0.5 to 3 parts of asiaticoside. The invention further discloses a preparation method and application of the medical composition. The medical composition disclosed by the invention can be used for rapidly reducing a wound area of damaged skin, remarkably shortening scabbing, scab falling and wound healing time and accelerating skin wound healing speed; the medical composition can be used for effectively repairing the damaged skin and has relatively strong actual application value.

The invention belongs to the field of a medical preparation, and particularly relates to a liquid adhesive bandage and a preparation method thereof. The liquid adhesive bandage disclosed by the invention comprises the following components in percentage by mass: 52.29% to 78% of antibacterial liquid, 8.51% to 29.5% of healing liquid and 10% to 20% of film-forming agent; based on the mass percentage of the liquid adhesive bandage, the healing liquid contains 0.01% to 0.5% of hyaluronic acid and 0.5% to 3% of asiaticoside; and the antibacterial liquid contains 0.09% to 0.9% of antibacterial peptide and 0.9% to 9% of chitosan. The liquid adhesive bandage disclosed by the invention has good air permeability and waterproofness, is fragrant in smell, is easy to strip after film formation, is short in film formation time, and has excellent antibacterial activity and an effect of promoting wound healing.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a preparation method of asiaticoside. An enzymolysis method of asiaticoside provided by the invention has obviously higher yield and purity than those in an acid-base hydrolysis method, has low requirements on equipment, has the advantages of small environmental pollution, no environmental pressure and the like, and provides an effective method for researching and developing active substances of traditional Chinese medicine centella asiatica.

The invention discloses a medicine composition for preventing and treating diabetes mellitus and application of the medicine composition. The medicine composition comprises a component (i) rebamipideand / or an analog thereof, and a component (ii) asiaticoside and / or an analog thereof. The medicine composition disclosed by the invention is capable of remarkably reducing the blood sugar and the incidence rate of an NOD (no obesity diabetes) mouse, improving the response capability to a glucose load, relieving pancreas islet inflammation, inhibiting expression of a Th1 type cell factor, promotingexpression of a Th2 type cell factor, reducing the death rate and taking functions of preventing and treating diabetes mellitus into play, and has wide application prospects.

The invention discloses a skin care product for improving skin anti-sensitivity and repairing ability, which is made of the following raw materials: 30-90 parts of pachysan, 0.1-10 parts of glycerin, 0.1-5 parts of trimethylglycine, and 0.01 parts of baicalin -3 parts, glycyrrhizin 0.01-5 parts, asiaticoside 0.01-5 parts, deionized water 0-69.77 parts. The present invention selects amino acid moisturizer with natural structure and naturally sourced polysaccharide compound, which can not only rapidly improve the water retention capacity of the skin, firmly lock the water, stimulate cell vitality, but also improve the skin's response to baicalin and glycyrrhizin. , asiaticoside and other natural anti-inflammatory active ingredients, so as to play anti-inflammatory and anti-itching effects, improve skin anti-sensitivity and repair ability; the formula is simple, and the raw materials are almost all derived from plant ingredients, avoiding the stimulation of chemical synthetic ingredients , can effectively improve the redness, swelling, itching, peeling and other symptoms of sensitive skin, make the skin feel comfortable and safe and re-establish the skin barrier function; the preparation process is simple and the cost is low.

The invention relates to a plant active component composition with slow anti-allergic action. The plant active component composition is mainly prepared from natural plant active components: 0.1-5wt% of glycyrrhetinic acid, 0.05-1wt% of apigenin, 0.05-1% of table gallic catechin gallic acid ester, 0.1-3wt% of asiaticoside, 0.1-5wt% of baicalin and 0.1-10wt% of fucus serratus extract. The composition is used for preparing cosmetics or personal care products with a plurality of effects of resisting skin allergy, diminishing inflammation, relieving itching, resisting oxidation, moisturizing and the like. The composition is safe and free of toxic and side effects, and can be compounded with a plurality of components, sensitive skin and dry skin are effectively improved, and the barrier function of the skin is reinforced.

The invention discloses a medicine composition for treating acne and an application thereof. The medicine composition is prepared by combining the following components: asiaticoside, osthole, cryptotanshinone, paeonol and chlorogenic acid, wherein the weight ratio of asiaticoside to osthole to cryptotanshinone to paeonol to chlorogenic acid is (3-6) to (3-6) to (2-4) to (2-4) to (3-6). The medicine composition is applied to preparation of a medicine preparation for skin or a cosmetic. The medicine composition has the effect of treating acne, has good effects and is safe and reliable.

The invention provides an anti-aging composition and application thereof, and particularly relates to the anti-aging composition having an effect of stabilizing adhesion between epidermis and dermis as well as application thereof. The composition is prepared from the following various components in percentage by weight: 20 to 30 percent of peony extract, 5 to 15 percent of oat polypeptide, 5 to 10percent of asiaticoside, 5 to 15 percent of soy isoflavone, 5 to 15 percent of ormosia henryi Prain bark extract, 1 to 5 percent of acetyl hydroxyproline, 10 to 20 percent of ginseng extract, and 10to 20 percent of cordyceps sinensis extract. The anti-aging composition disclosed by the invention has the following beneficial effects that the anti-aging composition has more action targets, promotion on expression of collagen protein is achieved, the stable adhesion between the epidermis and the dermis also can be maintained; the collaborative ability is strong, the effect of the composition exceeds the effect of a single raw material; the action effect is mild and irritability is low.

A kind of spinning, which is made by blending PLGA, PEO and asiaticoside through stable jet electrospinning technology, and has the same orientation. Wherein, the weight ratio of PLGA to PEO is 4:1, and the dosage of asiaticoside is 10wt% of PLGA. The spinning of the present invention has significantly improved hydrophilicity, has the effect of regulating macrophage phenotype transformation and anti-inflammation in vivo, and can be used to prepare medicines or medical devices for regulating macrophage phenotype transformation and anti-inflammation in vivo (such as: stand).

The invention discloses a medicine composition for preventing and treating diabetes mellitus and application of the medicine composition. The medicine composition comprises a component (i) rebamipideand / or an analog thereof, and a component (ii) asiaticoside and / or an analog thereof. The medicine composition disclosed by the invention is capable of remarkably reducing the blood sugar and the incidence rate of an NOD (no obesity diabetes) mouse, improving the response capability to a glucose load, relieving pancreas islet inflammation, inhibiting expression of a Th1 type cell factor, promotingexpression of a Th2 type cell factor, reducing the death rate and taking functions of preventing and treating diabetes mellitus into play, and has wide application prospects.

The invention discloses asiaticoside-chitosan-sodium alginate microspheres, a preparation method and application thereof, and belongs to the technical field of biomedical materials. The microspheres are prepared by an emulsification cross-linking method and finally obtained by freeze-drying. The preparation method comprises the following steps: 1) preparing sodium alginate solution and asiaticoside-chitosan acetic acid solution respectively; 2) slowly and uniformly adding sodium alginate solution to the oil phase, stirring at high speed to form colostrum; 3) ) Slowly and evenly add the asiaticoside-chitosan acetic acid solution to the colostrum, stir, and fully emulsify; 4) Slowly and evenly add the glyceraldehyde solution to cross-link and solidify, centrifuge, and the precipitate is washed with petroleum ether successively. washing, washing with absolute ethanol, and vacuum freeze-drying to obtain light yellow powder of asiaticoside-sodium alginate-chitosan microspheres.

The invention discloses acne-removing gel. The acne-removing gel comprises the following ingredients in parts by weight: a phase A: 60-80 parts of water, 0.01-0.03 part of EDTA-2Na, 0.40-0.60 part ofCarbomer 2020, 2-4 parts of glycerin and 2-4 parts of glyceryl polyether-26; a phase B: 0.50-0.70 part of arginine and 4-6 parts of water; and a phase C: 1.5-2.5 parts of sophorolipid, 1-3 parts of wrapping salicylic acid, 1-3 parts of bioflavanoid, 1-3 parts of witch hazel extract, 1-3 parts of aloe extract, 2-4 parts of asiaticoside and 2-4 parts of methyl propanediol. The invention simultaneously discloses a preparation method for the acne-removing gel. According to the acne-removing gel and the preparation method therefor, the witch hazel extract and the aloe extract have the characteristics of high rate of extraction, good extract activity and good acne-removing product performance.

The invention belongs to the field of traditional Chinese medicine, provides a medicine composition for treating rhinitis and discloses a medicine composition for treating rhinitis, a preparation method thereof and a quality inspection method. The medicine composition is prepared from, by weight, 1-2 parts of cypress fruits, 1-2 parts of microsorium fortunei ching, 1-2 parts of thyrocarpus glochidiatus and 1-2 parts of panax notoginseng. The medicine composition is prepared into nose drops through a conventional pharmaceutical method in traditional Chinese medicine pharmacology. The method for measuring the content of asiaticoside through efficient liquid phase chromatography is provided and a method for measuring the content of ageratum conyzoides chromene and coumarin through gas chromatography is further provided. The medicine composition can be used for preparing medicine for treating rhinitis, allergic rhinitis and chronic hypertrophic rhinitis.

The invention relates to a sunscreen composition with a cellular level repairing effect and application thereof. The sunscreen composition comprises the following components in percentage by weight of15-25% of camellia extract, 0.5-1.5% of green tea extract, 0.5-1.5% of of algal polysaccharides, 0.5-1.5% of glabridin, 0.5-1.5% of asiaticoside, 65-80% of water and 1-5% of emulsifier. The sunscreencomposition provided by the invention can repair skin injury caused by UVB from a cellular level, alleviates the phenomena of skin barrier damage, skin aging, erythema and the like caused by UVB, andcan also increase the sunscreen index of a sunscreen agent and improve the sunscreen effect of a product through a synergistic effect. Water-soluble and oil-soluble components are fused through an emulsification process, so that the application of active substances is facilitated, and in addition, the composition is mild in action effect, natural, safe and low in irritation.

The invention belongs to the technical field of medicine, in particular, it relates to an HPLC characteristic spectrum of Sanjin preparation and a construction method thereof. The HPLC characteristic spectrum includes 9 characteristic peaks, wherein No. 6 peak is the asiaticoside reference peak, and the relative retention times of the other 8 characteristic peaks are: No. 1 peak 0.41, No. 2 peak 0.53, No. 3 peak 0.13, Peak No. 4 is 0.12, Peak No. 5 is 0.26, Peak No. 7 is 0.14, Peak No. 8 is 0.13, and Peak No. 9 is 0.12. The present invention establishes the characteristic map of n-butanol part of Sanjin tablet for the first time, which can synchronously track and detect multiple main components of the 4 flavors of the prescription under simple conditions, comprehensively improve the quality control standard of Sanjin preparation, and enhance the core competitiveness of the product. Lay a solid foundation to ensure the product quality and clinical efficacy of Sanjin Tablets are stable. In addition, the establishment method of the HPLC characteristic map has strong operability and good reproducibility, which provides a scientific basis for better controlling the quality of Sanjin preparations.

The invention belongs to the technical field of make-ups, and particularly relates to an acne removing preparation. The acne removing preparation is prepared from the following components in parts byweight: 1-3 parts of plant oil control factor, 0.5-2 parts of carboxymethyl yeast beta-glucan, 3-10 parts of acne bane, 0.2-1 part of asiaticoside, 0.05-0.2 part of dipotassium glycyrrhizinate and 1-6parts of folium / caulis myrothamni flabellifoliae extract. The preparation has a fast significant acne removing effect, a scar removing effect, an effect of significantly removing active oxygen in neutrophil, a bacteriostasis effect, effects of enhancing cell activity and promoting TIMP-1 factor secretion, and more uncommonly, a very good effect of repairing scars left in a disease course within one year.

The invention discloses for the first time the application of asiaticoside in the preparation of medicaments for treating skin cancer. The results of the DMBA / TPA two-step chemically induced mouse skin cancer model show that the therapeutic effect of asiaticoside on skin cancer is significantly better than that of the drugs used to treat scars, other AMPK agonists, clinical drugs for other cancers, and similar structures. medicine. The present invention provides a new drug choice for clinical treatment of skin cancer.