18 results about "Asialoganglioside" patented technology

The invention provides a composition and cream with anti-inflammatory and skin barrier injury repairing effects as well as a preparation method and application of the composition and cream, and belongs to the technical field of skin injury repairing. The invention provides a composition with anti-inflammatory and skin barrier injury repairing effects. The composition is prepared from matrine, dipotassium glycyrrhizinate, bisabolol and asiaticoside according to the weight ratio of 1: 1: 1: 1. The composition provided by the invention can play a role through a multi-target mechanism, such as up-regulation of Invoucrin, and provides a more effective prevention and treatment scheme for skin barrier dysfunction related diseases and sensitive skin.

The invention discloses a composition for treating intractable skin infection, sores and ulcers and inflammation as well as a preparation method and application of the composition, and belongs to the technical field of functional compositions. The composition is prepared from the following components in parts by mass: 1 to 5 parts of baicalin, 0.5 to 3 parts of antibacterial alkaloid, 2 to 6 parts of asiaticoside, 3 to 8 parts of salvianolic acid B, 1 to 4 parts of gallic acid, 5 to 10 parts of rhizoma bletillae polysaccharide, 3 to 10 parts of konjac glucomannan, 3 to 5 parts of chitosan, 8 to 20 parts of glycerol, 0.5 to 2 parts of genipin, 1 to 3 parts of calcium chloride, 1 to 3 parts of laurocapram and 40 to 80 parts of water. The antibacterial alkaloid comprises berberine or phellodendrine. Based on deep understanding of an intractable skin pathological mechanism, the components are scientifically matched, and the composition shows a remarkable synergistic effect in in-vitro antibacterial, anti-biofilm and anti-inflammatory experiments. The preparation process is simple, low in cost and suitable for industrial production.

This invention relates to the field of asiaticoside technology, and discloses asiaticoside liposome compositions, preparation methods, and applications. Specifically, based on molecular design principles, monoprotonated tertiary amine permeation enhancers and diprotonated tertiary amine permeation enhancers are synthesized. Using egg yolk lecithin, cholesterol, monoprotonated or diprotonated tertiary amine permeation enhancers, and asiaticoside as raw materials, asiaticoside liposome compositions are prepared by thin-film dispersion. The liposome composition exhibits a transdermal permeability of >90% after 48 hours, demonstrating excellent transdermal performance, and also possesses excellent encapsulation and drug loading properties, making it suitable for preparing gel formulations for treating skin lesions.

The application belongs to the field of natural product extraction and cosmetic raw materials, and discloses a preparation method and application of a composition containing asiaticoside-paeoniflorin, which comprises two key and functionally different stages: ① extraction stage: using asiaticoside as an extraction aid and using propylene glycol as a complex medium, efficiently dissolving and forming an "asiaticoside-paeoniflorin" supramolecular complex; ② complexing and stabilizing stage: using glycerol as a stabilizer to maintain the long-term kinetic stability of the formed supramolecular complex and prevent its dissociation and aggregation. The method solves the technical problem that the extraction rate and stability of paeoniflorin are difficult to be considered simultaneously in the field by functional division of extraction and stabilization, and the composition containing asiaticoside-paeoniflorin obtained finally has excellent soothing performance, not only rapid effect, but also persistent and stable soothing protection effect, which can effectively resist and repair the influence of external stimulation on the skin.

The invention provides a recombinant collagen patch for treating facial dermatitis and eczema and fading pigmentation and a preparation method of the recombinant collagen patch. The application comprises a base material layer and a functional composition loaded on the base material layer, wherein the functional composition comprises recombinant human collagen III, an anti-inflammatory active component and a whitening active component. Wherein the anti-inflammatory active component is a compound of ganoderma sinensis spore powder zymolyte, dipotassium glycyrrhizinate and asiaticoside in a specific mass ratio, and the whitening active component is an alpha-arbutin-ferulic acid condensate and a compound of tranexamic acid and glabridin in a specific mass ratio. And the base material layer is alginate-sodium carboxymethyl cellulose composite hydrogel which is modified by gamma-ray irradiation. Through the synergistic effect of all the active ingredients and the optimized preparation process, the multiple effects of resisting inflammation, repairing a barrier and fading hyperpigmentation are achieved, and the product is good in biocompatibility and remarkable in effect.

The application discloses an anti-wrinkle and firming composition suitable for multiple skin types and a preparation method and application thereof, and belongs to the technical field of cosmetics. The composition contains, in mass parts, 2.5-9.5 parts of an active functional component, 5-10 parts of a targeted delivery carrier system and cosmetically acceptable adjuvants. The active functional component is composed of ginsenoside Rb1, green tea extract-white resveratrol compound and asiaticoside-dipotassium glycyrrhizinate compound, and the targeted delivery carrier system is a transdermal peptide modified liposome and a natural nano-structured lipid carrier. The application constructs a double-targeted delivery system according to different skin aging mechanisms and skin characteristics, realizes single formula adaptation to multiple skin types, improves the transdermal efficiency of active ingredients and the targeted enrichment effect on the dermis, has no carrier residue, and multiple components synergistically play the effects of anti-wrinkle and firming, soothing and protection, is safe, and can be widely applied to the preparation of anti-aging skin care products.

The invention discloses a polypeptide-lipid nano composite particle and a preparation method and application thereof, the polypeptide-lipid nano composite particle comprises a polypeptide component and a phospholipid lipid carrier, and the polypeptide component is wrapped in the phospholipid lipid carrier. The preparation method comprises the following steps: S1, dissolving polysorbate-80 in a butanediol aqueous solution to obtain a solution (1); s2, dissolving lecithin with the solution (1) to obtain a solution (2); s3, dropwise adding the solution (2) into palmitic acid to obtain a solution (3); s4, mixing the asiaticoside solution and the polypeptide solution to obtain a solution 4; s5, slowly adding the solution (4) into the solution (3) to obtain a solution (5); and S6, diluting the solution (5) by 5-7 times with water to finally obtain the LNP solution. The lipid nanoparticles prepared by the invention can effectively wrap polypeptide, improve the stability of the polypeptide, and contribute to skin permeability, so that the skin care effect of polypeptide active molecules is improved.

The present application provides a kind of pharmaceutical composition for vulvar sclerosing lichen and its preparation method, the pharmaceutical composition includes active ingredient and pharmaceutically acceptable vulva local administration adjuvant, active ingredient is made of 0.005-0.02 parts of mometasone furoate, 0.05-0.3 parts of calcineurin inhibitor, 0.5-2 parts of paeoniflorin, 0.8-3 parts of asiaticoside, 0.3-1.5 parts of recombinant collagen, 0.2-1 part of ginkgolide B.The present application is aimed at the core pathogenesis of disease, constructs multi-target whole course of disease synergistic therapy system, can realize anti-inflammatory regulation, anti-fibrosis, basement membrane repair, microcirculation improvement simultaneously, low-dose strong effect, greatly reduce side effect and recurrence rate;Liposome targeted delivery technology is used, the stability of active ingredient is guaranteed, process controllable adaptation industrialization production, and clinical application prospect is wide.

The present application relates to the technical field of pharmaceutical preparation, in particular to a kind of asiaticoside nanostructured lipid carrier and preparation method thereof.The nanostructured lipid carrier is formed by homogenization after water phase and oil phase are mixed, wherein the water phase is a solution containing emulsifier, the oil phase is a mixed solution containing asiaticoside, solid lipid and liquid lipid, and is prepared by melt emulsification-high pressure homogenization method.The asiaticoside nanostructured lipid carrier prepared by the present application has the advantages of small particle size, high encapsulation efficiency and good stability, and the preparation method is simple and controllable, with good repeatability, solving the problems of asiaticoside not easily soluble in water and low bioavailability, and providing a selectable delivery system for asiaticoside.

This invention belongs to the field of natural product extraction and cosmetic raw materials, and discloses a method for preparing a composition containing asiaticoside-paeoniflorin and its application. The preparation method includes two key and functionally distinct stages: ① Extraction stage: using asiaticoside as an extraction aid and propylene glycol as a composite medium, efficiently dissolving and forming a supramolecular complex of "asiaticoside-paeoniflorin"; ② Complex stabilization stage: using glycerol as a stabilizer to maintain the long-term kinetic stability of the formed supramolecular complex and prevent its dissociation and aggregation. This method, through the functional division of labor between extraction and stabilization, synergistically solves the long-standing technical problem in the field of balancing the extraction rate and stability of paeoniflorin. Furthermore, the composition containing asiaticoside-paeoniflorin obtained by this invention possesses excellent soothing properties, not only acting rapidly but also providing long-lasting and stable soothing protection, effectively combating and repairing the effects of external stimuli on the skin.

The application discloses a pH-sensitive asiaticoside drug-loaded micelle as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations. The drug-loaded micelle takes mPEG-PLGA-PHis triblock copolymer as a carrier, realizes high drug loading, high encapsulation efficiency and pH 5.5 precise response drug release by limiting the molar ratio of lactic acid and glycolic acid to 70:30-80:20, the specific molecular weight interval of each block and the mass ratio, the micelle particle size is 30-120 nm, the structure is stable in a neutral environment, and the drug is quickly released by depolymerization in an inflammatory micro-acid environment. The preparation adopts a film dispersion-dialysis process, has low organic solvent residue, uniform particle size, good batch repeatability and is suitable for industrial production. The drug-loaded micelle can be made into gel, cream and other external preparations, is used for skin inflammation repair, wound healing, scar lightening and post-medical beauty repair and has good clinical application and industrial value.

The invention relates to an allicin-containing pharmaceutical composition for treating eczema and a preparation method of the allicin-containing pharmaceutical composition, and belongs to the technical field of pharmaceutical compositions. In order to solve the problem that an existing eczema treatment medicine is difficult to consider anti-inflammatory, antibacterial and skin barrier repair at the same time, the invention provides the allicin-containing pharmaceutical composition for treating eczema, and the allicin-containing pharmaceutical composition contains the following effective pharmaceutical ingredients: an allicin inclusion compound, ceramide, sophocarpidine, baicalin, forsythin, asiaticoside and glycyrrhizic acid. Through scientific compatibility of various active components, an antibacterial-anti-inflammatory-repair triple synergistic treatment system is constructed, and the treatment targets of rapid symptom control in the acute stage, continuous repair in the chronic stage and prevention of infection and recurrence in the whole process of eczema treatment are achieved. Aiming at the defect of strong irritation of the allicin, the pharmaceutical composition containing the allicin is prepared into an oil-in-water cream form, so that the problems of stability and irritation of active ingredients of the allicin are solved, and the treatment targets of high efficiency and low toxicity are realized.

This invention discloses a composition with whitening and anti-wrinkle functions, its preparation method, and its application. The composition combines Asian birch sap and Rosa damascena flower water to replenish basic moisture and nutrients to the skin, soothing discomfort. Niacinamide, α-arbutin, 3-o-ethyl ascorbic acid, 4-butylresorcinol, and glutathione work synergistically to achieve whitening effects. Acetyl hexapeptide-8 reduces expression line formation by inhibiting neurotransmitter release, and, combined with palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, and hydroxypropyl tetrahydropyranotriol, reduces fine lines, achieving anti-wrinkle and firming effects. Hyaluronic acid, sodium hyaluronate, hydrolyzed hyaluronic acid, sodium hyaluronate crosspolymer, and acetylated sodium hyaluronate form a multi-moisturizing system, combined with butylene glycol, trehalose, betaine, and glycerin to lock in skin moisture. Centella asiatica extract, asiaticoside, asiaticoside, Scutellaria baicalensis root extract, Paeonia lactiflora root extract, and other plant extracts soothe the skin.

The application belongs to the technical field of hydrogel preparation, and discloses a quaternary ammonium salt modified chitosan-based composite hydrogel and a preparation method thereof. The composite hydrogel is obtained by mixing an O-quaternary ammonium salt chitosan O-HACC solution and a 3-maleimide propionic acid modified pullulan PL-MA solution according to a certain proportion and standing. The OHACC solution and the PL-MA solution are simply mixed, and the composite hydrogel is quickly prepared by using the reaction between the groups of the two compounds. The hydrogel has a connected porous structure, good self-healing performance, injectable performance, adhesion performance, antibacterial performance and biocompatibility. After the hydrogel in the application in situ encapsulates nanoparticles containing asiaticoside, it is found through a mouse full-thickness skin damage model that the drug-loaded hydrogel in the application can promote the rapid and perfect healing of a wound.

The application provides a medicine umbilical cord mesenchymal stem cell factor and a preparation method thereof, belongs to the biotechnology field, and the preparation method comprises the following steps: inducing and culturing the third generation of expanded cells of umbilical cord mesenchymal stem cells, the induction culture medium contains epidermal growth factor, vascular endothelial growth factor, deferoxamine, vitamin C, rapamycin, asiaticoside, astragaloside IV, astragalus polysaccharide and the like, the secretion of the target factor is effectively promoted, cell differentiation is controlled, two kinds of chromatography columns are used for purification and extraction, the product yield is high, the purity is high, and the efficacy of the product is further improved.

This invention discloses a stable synergistic composition based on asiaticoside and ergothioneine, which mainly comprises asiaticoside and ergothioneine, wherein the weight ratio of asiaticoside to ergothioneine is 0.5-5:1-8, and the content of asiaticoside in the composition is 0.05-2 wt%. This invention also discloses the application of asiaticoside in inhibiting the photodegradation of ergothioneine, the antioxidant use of the composition based on asiaticoside and ergothioneine, the use of the composition based on asiaticoside and ergothioneine as an FLG gene expression promoter, or a LOR gene expression promoter, or a Claudin-1 gene expression promoter, and the use of this composition in topical skin preparations.

The invention discloses a light-operated cross-linked intelligent gel dressing of ginseng exosome composite self-assembled micelle and application of the light-operated cross-linked intelligent gel dressing, and belongs to the technical field of biology. The intelligent ginseng exosome with cell penetrating peptide modification and endosome escape functions is constructed through an ultrasonic incubation method, and meanwhile, the light-controlled cross-linked intelligent gel dressing capable of forming gel in situ is developed by adopting a light cross-linking technology. According to the dressing, the angiogenesis promoting function of the intelligent ginseng exosome and the collagen secretion promoting characteristic of the asiaticoside-loaded micelle are creatively integrated, efficient cell uptake is achieved through a gridding protein mediated endocytosis pathway, and endosome escape is completed by utilizing an environmental response mechanism. The co-loading system constructed by the invention has dual functions of wound protection and tissue regeneration, and a novel external preparation solution with high efficiency and safety is provided for local treatment of diabetic foot ulcer.

The present invention relates to a pharmaceutical composition comprising a TGF-beta receptor inhibitor selected from the group consisting of Galunisertib (LY2157299), Vactosertib (EW-7197), Itacnosertib (TP-0184), and Repsox (E-616452), and at least one pharmaceutically acceptable carrier, excipient and / or diluent, for use in the treatment of a fibrotic lung disease, in particular idiopathic pulmonary fibrosis (IPF). Preferably, the at least one excipient of the pharmaceutical composition for use according to the invention comprises triterpenoid saponin molecules, more preferably asiaticoside and / or glycyrrhizin molecules.