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Medical application of composition consisting of anhydroicaritin and asiatic acid

A technology of icariin and asiatic acid is applied in the field of medicine to achieve the effect of enhancing the therapeutic effect, reducing the dosage of the two and achieving good therapeutic effect

Pending Publication Date: 2021-05-11
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] After searching, there is currently no report on the combination of icariin and asiatic acid for the treatment of psoriasis

Method used

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  • Medical application of composition consisting of anhydroicaritin and asiatic acid
  • Medical application of composition consisting of anhydroicaritin and asiatic acid
  • Medical application of composition consisting of anhydroicaritin and asiatic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Effect of the composition of Example 1 on imiquimod-induced psoriasis-like skin lesions in mice

[0032] 1. Animal modeling, grouping and administration

[0033] 1.1 Modeling and grouping

[0034] Depilate the back of BABL / c mice, with an area of ​​about 2cm×1.5cm, with gentle movements to avoid damaging the skin. 80 mice were randomly divided into 8 groups according to the random number table method, 10 mice in each group, and raised in separate cages according to the groups, and fed with sterilized water and common mouse chow every day.

[0035] A group was randomly selected as the normal control group, and about 0.5 mL of distilled water was applied to the hairless back area every day; 5% imiquimod cream was applied to the hairless back area of ​​the remaining 7 groups, 60 mg / d (the effective drug was 3 mg / d). ), for 6 consecutive days, if relatively stable erythematous and scaly skin lesions appeared on the back of the mouse, it was judged that the model was succe...

Embodiment 2

[0072] Example 2 Effect of external application of composition on imiquimod-induced psoriasis-like skin lesions in mice

[0073] 1. Animal modeling, grouping and administration

[0074] 1.1 Modeling and grouping

[0075] The ears of BABL / c mice were shaved with an area of ​​about 2cm×1.5cm, and the movements were gentle to avoid damaging the skin. 80 mice were randomly divided into 8 groups according to the random number table method, 10 mice in each group, and raised in separate cages according to the groups, and fed with sterilized water and common mouse chow every day.

[0076] A group was randomly selected as the normal control group, and about 0.5 mL of distilled water was applied to the hairless ear area every day; the other 7 groups were applied with 250 mg:12.5 mg imiquimod cream once a day in the morning for 7 consecutive days to prepare imiquimod Induced mouse model of psoriasis. During the modeling process, each drug administration group continuously applied diff...

Embodiment 3

[0106] The preparation of embodiment 3 tablet

[0107] Prescription: icariin 10g, asiatic acid 20g, microcrystalline cellulose 25g, lactose 20g, magnesium stearate 1.5g.

[0108] After uniformly mixing the above-mentioned raw materials and auxiliary materials, it is wet granulated according to conventional methods, dried and pressed into tablets to obtain the product.

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Abstract

The invention belongs to the field of medicine, and particularly relates to medical application of a pharmaceutical composition. The pharmaceutical composition consist of anhydroicaritin and asiatic acid. The invention further discloses application of the pharmaceutical composition to preparation of a drug for treating psoriasis. The pharmaceutical composition disclosed by the invention has the advantages of good curative effect, no side effect and high safety when being used for treating the psoriasis, and has a good development prospect and social and economic benefits.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the medical application of a pharmaceutical composition, in particular to the application of a composition containing icarigenin and asiatic acid in the preparation of medicines for treating psoriasis. Background technique [0002] Icariin is a flavonol compound, a small amount exists in Epimedium medicinal materials, and its chemical structure is as follows: [0003] [0004] Epimedium aglycon can be isolated from Epimedium medicinal material (Sun Pengyue, Xu Ying, Wen Ye et al., Chemical Constituents of Korean Epimedium, Chinese Journal of Phytochemistry, 1998, 8(2): 122-125), or Separation of icariin by enzymatic hydrolysis (Ye Haiyong, Liu Jian, Lou Yijia, Preparation of icariin derivatives and their estrogen-like effects, Journal of Zhejiang University, 2005, 34(2): 131 -136). [0005] It has been reported in the literature that icariin has anti-Aβ peptide-induced apoptosis in pri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/56A61K31/352A61P17/06
CPCA61K31/56A61K31/352A61P17/06A61K2300/00
Inventor 张贵民王升兰王现珍
Owner LUNAN PHARMA GROUP CORPORATION