Nerve sheathing canal as well as preparation method and application thereof

Abstract

The invention relates to a nerve sheathing canal as well as a preparation method and an application thereof. The nerve sheathing canal comprises a composite sheathing canal formed by an I-type collagen composite material and I-type collagen filled in pores of the composite sheathing canal. The method comprises the following steps: uniformly mixing an I-type collagen solution with a mineral material containing calcium ions to obtain an I-type collagen composite material solution; pouring the I-type collagen composite material solution into the cylindrical mold cavity and then freeze-drying, and obtaining a composite sheath tube; placing the composite sheathing canal in a negative pressure mold, and filling pores of the composite sheathing canal with an I-type collagen solution under the negative pressure condition; sequentially performing the freeze drying on the filled composite sheathing canal, then performing steps of crosslinking and elution, and preparing the nerve sheathing canal. The nerve sheath tube is simple in preparation process, has the advantages of being appropriate in mechanical strength, good in biocompatibility, convenient to degrade in vivo and the like, and is a convenient, safe and effective peripheral nerve repairing material.

Description

technical field [0001] The invention belongs to the technical field of medical device materials, and in particular relates to a nerve sheath and its preparation method and application. Background technique [0002] Peripheral nerve defect is one of the most common traumas in clinical practice. It is reported that its incidence accounts for 1.5% to 4.0% of trauma patients every year, and the number of cases in China is as high as 600,000 to 900,000 cases per year. Clinically, compared with skin, soft tissue, joint, bone and other injuries, nerve injury is more difficult to deal with, with a long recovery period, lack of effective measures, and sometimes the prognosis is not ideal. Nerve damage can result in complete loss of sensory and / or motor function in the distal extremity innervated by the affected nerve. If the stump is damaged and not repaired effectively, the surrounding connective tissue can prevent the nerve from growing and repairing over time. The formation of ne...

AI Technical Summary

Problems solved by technology

The repair of long-distance defects is clinically more difficult.

The most commonly used method at present is to use autologous nerve grafting to bridge and repair nerve stumps. Even though this method is considered to be the "gold standard" of clinical work, it still has many disadvantages: such as limited nerve sources, impaired function of donor nerves, and scar formation and infection risk in the area, and studies have shown that only 40% to 50% of patients can achieve complete recovery of motor function after autologous nerve transplantation, so it is necessary to find an alternative to autologous nerve transplantation

However, due to a series of problems such as poor biocompatibility of chemical materials, poor mechanical properties of biological materials and biological tubes, the repair effect is not good, and the clinical application is limited.

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