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Antipathogenic compositions and methods thereof

A composition and pathogenic technology, applied in antibacterial and antifungal compositions, antiviral fields, capable of solving problems such as mammalian cell damage

Pending Publication Date: 2021-06-04
SINTX TECH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Solid-state inactivators release Cu and Ag ions, which may induce damage to mammalian cells

Method used

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  • Antipathogenic compositions and methods thereof
  • Antipathogenic compositions and methods thereof
  • Antipathogenic compositions and methods thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0074] Example 1: Effect of Silicon Nitride Concentration on Virus Inactivation

[0075] To show the effect of silicon nitride concentration on the inactivation of the virus, influenza A was exposed to various concentrations of Si 3 N 4 powder. To prepare silicon nitride, a certain weight of silicon nitride powder is mixed with pure distilled water. For example, 7.5g of silicon nitride is dispersed in 92.5g of pure distilled water. Add virus to this mixture at concentrations of 1:1, 1:10, and 1:100 virus / mix, respectively. These mixtures were then incubated for 10 min at 4°C with gentle agitation. Influenza A was exposed to 0 wt.%, 7.5 wt.%, 15 wt.% and 30 wt.% Si at 4°C 3 N 4 10 minutes, such as Figure 2A as shown. The mixture is then filtered to remove silicon nitride powder.

[0076] Then for Si 3 N 4 Effectiveness in inactivating influenza A was observed on Madin-Darby canine kidney (MDCK) cells inoculated with influenza A virus. The remaining mixture was the...

example 2

[0078] Example 2: Effect of exposure time and temperature on virus inactivation

[0079] To show the effect of silicon nitride on the inactivation of the virus, influenza A was exposed to a fixed concentration of Si at various times and temperatures 3 N 4 Powder (15 wt.%). The mixture was then incubated with gentle agitation at room temperature and 4°C for 1-30 minutes. For example, influenza A was exposed to 15wt.% Si at room temperature or 4°C 3 N 4 1 minute, 5 minutes, 10 minutes or 30 minutes, such as Figure 3A as shown. Then for Si 3 N 4 The effectiveness in inactivating influenza A was observed on Martin-Darby dog ​​kidney (MDCK) cells inoculated with influenza A virus. according to Figure 3B , with exposure to Si 3 N 4 Three days after the influenza A virus was inoculated into the MDCK cells, the viability of the cells was measured.

[0080] Figure 7A is exposed to 15wt.% Si at room temperature 3 N 4 Graph of PFU / 100 μl of influenza A for 1 min, 5 mi...

example 3

[0082] Example 3: Effect of Silicon Nitride on the Inactivation of H1H1 Influenza A

[0083] To show the effect of silicon nitride on the inactivation of viruses, influenza A was exposed to a slurry of 15 wt.% silicon nitride for 10 minutes.

[0084] Figures 15A-15C Shows H1H1 influenza A virus (A / Puerto Rico / 8 / 1934 H1N1 (PR8)) inoculated into organisms containing MDCK cells stained green in the presence of filamentous actin (F-actin) After being in the source medium, it is stained red (nucleoprotein, NP), the filamentous actin present in all eukaryotic cells. Figures 16A-16C The effect of virus on MDCK cells in the absence of silicon nitride is shown.

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PUM

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Abstract

Disclosed herein are compositions, devices and methods for inactivating viruses, bacteria, and fungi. The compositions, methods, and devices may include coatings or slurries such as silicon nitride powder coatings or slurries for the inactivation of viruses, bacteria, and / or fungi.

Description

technical field [0001] The present disclosure relates to antiviral, antibacterial and antifungal compositions, systems, methods and devices. More specifically, the present disclosure relates to silicon nitride compositions, devices and coatings for the inactivation and lysis of viruses, bacteria and fungi. Background technique [0002] There is a general need for safe and reliable inactivation, removal or lysis of viruses, bacteria and fungi. There is a widespread need to control pathogens that affect human health and agricultural products. Not only are materials required to have anti-pathogenic properties for human drug therapy, but they are also required as surface coatings for various medical devices or instruments, examination tables, clothing, filters, masks, gloves, catheters, endoscopic instruments, etc. and / or the use of the complex. [0003] Furthermore, the application of anti-pathogenic raw materials is highly desirable in agriculture. As much as 15% of the wo...

Claims

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Application Information

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IPC IPC(8): A23L3/26A61L2/00A61L2/08
CPCC01B21/068A01N59/00A61L29/16A61L31/16A61L27/54A61L2300/404A01N25/34A01N25/12A01C1/06A01N59/02A01N25/32
Inventor B·J·麦肯泰尔R·M·博克B·S·巴尔
Owner SINTX TECH INC