High-adhesion slow-release cross-linked hydrogel and preparation method thereof
A technology of cross-linked hydrogel and high adhesion is applied in the field of hydrogel preparation, which can solve the problems of poor stability of hydrogel, loss of adhesion, time-consuming and laborious, and achieves simple preparation method and high preparation efficiency. Effect
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[0038] The preparation method comprises the following steps:
[0039] S1. Prepare methacryl hydrogel matrix material;
[0040] S2. preparing carboxylated methacryl hydrogel matrix material;
[0041] S3. Dissolve the carboxylated methacrylated hydrogel matrix material prepared in step S2 in deionized water, and adjust the pH value of the solution to 8-9, then add the free radical crosslinking initiator and The aluminum glycinate powder is uniformly stirred, left standing for defoaming, and then poured into a mold, and ultraviolet light triggers crosslinking to obtain the high-adhesive slow-release crosslinked hydrogel.
[0042] The hydrogel prepared by this method can reach an initial adhesion force of 18# steel ball or more, and the repeated adhesion has an adhesion effect of more than 10 times. And the adhesion performance of similar products at present also can only reach the technical index that initial adhesion force is less than 14# steel ball, and repeated adhesion is ...
Embodiment 1
[0049] A high-adhesion slow-release cross-linked hydrogel prepared by the following steps:
[0050] S1. Preparation of methacrylated polyvinyl alcohol
[0051] Add 100ml of dimethyl sulfoxide and about 5.0g of polyvinyl alcohol into the three-necked flask in turn, put the three-necked flask into a constant temperature oil bath, stir at 40°C to completely dissolve the polyvinyl alcohol, and then add 0.11 g of p-dimethylaminopyridine catalyst g, after it is completely dissolved, add 0.32 g of glycidyl methacrylate, and after 30 minutes, quickly heat up the constant temperature oil bath, and start timing the reaction for 6 hours after the solution in the three-necked flask reaches 60°C. After the reaction, cool the solution to room temperature, then pour the solution into acetone to precipitate to form a milky white flocculent precipitate, then remove the precipitate every 3 hours, put it in acetone for cleaning, and after cleaning for 3-4 times, put the product in Vacuum drying...
Embodiment 2-3 and comparative example 1-2
[0063] A high-adhesion slow-release cross-linked hydrogel, compared with Example 1, the difference is that in step S2, the pH value is as shown in Table 1, and the others are roughly the same as in Example 1. This will not be repeated here.
[0064] The pH value and adhesion property test result of table 1 embodiment 1-3 and comparative example 1-2
[0065] Test case pH value Initial viscosity (ball number #) Repeated stickiness (times) Example 1 8.5 20# 12 Example 2 7.5 19# 12 Example 3 9 20# 11 Comparative example 1 6.5 8# 7 Comparative example 2 10 9# 5
[0066] It can be seen from Table 1 that when the pH is controlled at 8-9, the adhesion performance of the hydrogel is the best. This is because the solution is in a weakly alkaline environment, and aluminum mainly exists in the form of aluminum glycinate solid powder, in which a small amount of aluminum ions will dissociate. In the solution, aluminum glycinate a...
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