A dual-targeting polymer drug nanocarrier and its preparation method and application

A nano-carrier, dual-targeting technology, applied in the field of nano-biomedical materials, can solve problems such as complex functions, central toxicity and side effects, and weakened therapeutic effects.
CN112957480BActive Publication Date: 2022-08-02INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
Publication Date
2022-08-02

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Abstract

The invention provides a dual-targeting polymer drug nanocarrier, which belongs to the field of nano-biomedical materials. Modified with a tumor-targeting functional molecule and a brain-targeting peptide, the tumor-targeting functional molecule is folic acid, and the brain-targeting peptide and the nanomaterial are connected through a sulfhydryl-maleimide group; the present invention is biodegradable The polylactic-glycolic acid is the core, and the Angiopep-2 / folic acid dual-targeting polymer drug nanocarrier is obtained by surface modification of tumor-targeting functional molecules and brain-targeting peptides, which can effectively overcome the BBB barrier and target tumor cells at the same time. , which can be used as a nano-formulation encapsulating drug for targeted treatment of glioma.
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Description

technical field

[0001] The invention relates to the field of nanometer biomedical materials, in particular to a dual-targeting polymer drug nanocarrier and a preparation method and application thereof. Background technique

[0002] Glioma is the tumor with the highest incidence in the central nervous system, accounting for about 46% of intracranial tumors. It is considered to be one of the most destructive and lethal tumors, with strong malignant proliferation ability, high infiltration ability and rapid Recurrence ability. Due to the unclear boundary between brain tumor tissue and normal tissue, it is difficult to completely remove the tumor, and the success rate is low. The existence of blood-brain barrier (BBB), blood-cerebrospinal fluid barrier (BCB) and blood-tumor barrier (BTB) also makes the Some chemotherapeutic drugs are difficult to reach the brain tissue, and the concentration of drugs at the tumor site is low, which is not enough to kill tumor cells. Therefore,...

Claims

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