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Embolism microsphere, preparation method thereof and drug-loaded embolism microsphere

A technology for embolizing microspheres and microspheres, applied in the field of medical materials, can solve the problems of microsphere drift, easy recurrence, non-tumor vascular embolism, etc., and achieve the effects of efficient loading, suitable size range, and strong hydroxyl adsorption capacity

Active Publication Date: 2021-06-15
苏州微尺度科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] During TACE treatment, if the particle size of the embolization microspheres used is too large, the level of the embolized arteries will be higher, which may cause embolization of non-tumor blood vessels and damage normal tissues, and it is difficult for the microspheres with too large a size to treat the lesion blood vessels. Effective blockage of the distal end, embolization is not thorough enough, easy to relapse
In addition, if the particle size of the embolic microspheres is too small, there is a possibility of microsphere drift

Method used

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  • Embolism microsphere, preparation method thereof and drug-loaded embolism microsphere
  • Embolism microsphere, preparation method thereof and drug-loaded embolism microsphere
  • Embolism microsphere, preparation method thereof and drug-loaded embolism microsphere

Examples

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Embodiment 1

[0058] The present embodiment provides a kind of embolic microsphere, and its preparation method comprises the following steps:

[0059] (1) Dissolve 50g of polyvinyl alcohol in 450mL of pure water, heat to 60°C and stir and dissolve at a stirring speed of 300rpm, configure it into an aqueous solution of polyvinyl alcohol with a mass concentration of 10%, and pour it into the aqueous solution of polyvinyl alcohol after cooling down to room temperature 5g of glutaraldehyde was added to the mixture, stirred at a stirring speed of 300rpm for 20 minutes to mix thoroughly, and then the above solution was placed in a vacuum defoamer to remove air bubbles to obtain a precursor solution.

[0060] (2) Mix 100mL of ethanol and 10mL of acetone evenly, place it in a low-temperature bath and cool it down to -30°C to obtain a collected solution.

[0061] (3) Add the precursor solution to a 10mL syringe, install an 18G needle, and connect the syringe to the syringe pump at the same time, adj...

Embodiment 2

[0064] The present embodiment provides a kind of embolic microsphere, and its preparation method comprises the following steps:

[0065] (1) Dissolve 75g of fucoidan in 425mL of pure water, heat to 60°C and stir to dissolve at a stirring speed of 300rpm, configure a fucoidan aqueous solution with a mass concentration of 15%, and pour it into the fucoidan aqueous solution after cooling down to room temperature Add 8g of hydroxymethyl urea to the mixture, stir at a stirring speed of 300rpm for 20min to mix thoroughly, and then place the above solution in a vacuum defoamer to remove air bubbles to obtain a precursor solution.

[0066] (2) Mix 100mL of ethanol and 20mL of acetone evenly, place it in a low-temperature bath and cool it down to -40°C to obtain a collected solution.

[0067] (3) Add the precursor solution to a 10mL syringe, install an 18G needle, and connect the syringe to the syringe pump at the same time, adjust the injection speed to 3mL / h, place the needle holder ...

Embodiment 3

[0070] The present embodiment provides a kind of embolic microsphere, and its preparation method comprises the following steps:

[0071] (1) Dissolve 25g of polyvinyl alcohol in 475mL of pure water, heat to 60°C and stir and dissolve at a stirring speed of 300rpm, configure it into an aqueous solution of polyvinyl alcohol with a mass concentration of 5%, and pour it into the aqueous solution of polyvinyl alcohol after cooling down to room temperature 4g of glutaraldehyde was added to the mixture, stirred at a stirring speed of 300rpm for 20 minutes to mix thoroughly, and then the above solution was placed in a vacuum defoamer to remove air bubbles to obtain a precursor solution.

[0072] (2) Mix 100mL of ethanol and 20mL of acetone evenly, place it in a low-temperature bath and cool it down to -40°C to obtain a collected solution.

[0073] (3) Add the precursor solution into a 10mL syringe, install a 28G needle, and connect the syringe to the syringe pump at the same time, adj...

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Abstract

The invention discloses an embolism microsphere, a preparation method thereof and a drug-loaded embolism microsphere, and belongs to the field of medical materials. The preparation method of the embolism microspheres comprises the following steps: forming liquid drops from an aqueous solution containing a polyhydroxy polymer and a cross-linking agent under the electrostatic action, dripping the liquid drops into a collecting solution, dehydrating to obtain a microsphere primary product, and performing cross-linking reaction on the microsphere primary product to obtain the embolism microspheres. According to the preparation method, the size of the embolism microspheres can be accurately regulated and controlled within a proper range, and the prepared embolism microspheres can stably exist in water.

Description

technical field [0001] The present application relates to the field of medical materials, in particular, to an embolic microsphere, a preparation method thereof, and a drug-loaded embolic microsphere. Background technique [0002] The treatment method of transcatheter arterial embolization (TACE) has the advantages of less trauma, quick curative effect, and less side effects. This method has played an increasingly important role in clinical cancer treatment, especially in the treatment of advanced liver cancer. The treatment principle is that doctors With the assistance of imaging equipment, the embolic agent is perfused into the blood vessels of the tumor lesion through a microcatheter to block the blood supply, thereby achieving the goal of "starving" the tumor. The performance of embolic agents will greatly affect the effect of embolization surgery. Currently, embolic agents used clinically include lipiodol, gelatin sponge, embolization microspheres and other products. Co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/04A61L24/06A61L24/08A61L24/00C08J3/12C08J3/24C08L29/04C08L5/00
CPCA61L24/0015A61L24/06A61L24/046A61L24/08C08J3/12C08J3/24C08J2329/04C08J2305/00
Inventor 党萌
Owner 苏州微尺度科技有限公司
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