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Trollius chinensis bunge extract, antibacterial composition and application

A technology of nasturtium extract and antibacterial composition, applied in the field of traditional Chinese medicine extracts, can solve problems such as dysfunction, enhanced curative effect, and reduced curative effect

Active Publication Date: 2021-06-18
CHENGDE TIANYUAN PHARMACEUTICAL INDUSTRY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the combination of Chinese and Western medicine has certain complexity, which may enhance the curative effect, reduce the curative effect or even produce toxic and side effects.
And for antibacterial western medicines such as azithromycin, cephalosporin antibiotics, etc., although the antibacterial effect is excellent, most of them have certain gastrointestinal reactions, and even cause gastrointestinal dysfunction and reduce the absorption and utilization of drugs.

Method used

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  • Trollius chinensis bunge extract, antibacterial composition and application
  • Trollius chinensis bunge extract, antibacterial composition and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] This embodiment provides a kind of nasturtium extract, and its preparation method specifically comprises the following steps:

[0024] Step a, put the fried charcoal of the nasturtium, place it in water with a pH of 5.5 (adjust the pH with citric acid) equivalent to 6 times the weight of the fried charcoal of the nasturtium, add 2.0% cellulose equivalent to the weight of the fried charcoal of the nasturtium The enzyme was stirred at 40-45°C for 2.5 hours, then the temperature was raised to 95°C and kept for 10 minutes to kill the enzyme;

[0025] Step b. Centrifuge the enzymatically hydrolyzed material for 7 minutes at a rotational speed of 3200 r / min, take the supernatant, add ethanol until the concentration of ethanol reaches 70% by volume, let stand for 18 hours, and remove the precipitate. Vacuum-dry the feed solution at 40-50°C to obtain.

Embodiment 2

[0027] This embodiment provides a kind of nasturtium extract, and its preparation method specifically comprises the following steps:

[0028] Step a, frying the charcoal of the nasturtium, placing it in water with a pH of 5 (adjusting the pH with citric acid) equivalent to 4 times the weight of the fried charcoal of the nasturtium, adding 1.5% cellulose equivalent to the weight of the fried charcoal of the nasturtium The enzyme was stirred at 40-45°C for 3 hours, then the temperature was raised to 95°C, and kept for 15 minutes to inactivate the enzyme;

[0029] Step b. Centrifuge the enzymatically hydrolyzed material for 8 minutes at a rotational speed of 3000 r / min, take the supernatant, add ethanol until the concentration of ethanol reaches 75% by volume, let stand for 12 hours, and remove the precipitate. Spray-dry the feed solution at 40-60°C to obtain.

Embodiment 3

[0031] This embodiment provides a kind of nasturtium extract, and its preparation method specifically comprises the following steps:

[0032] Step a, stir-fry the nasturtium with charcoal, place it in water with a pH of 6 (regulate the pH with citric acid) equivalent to 7 times the weight of the golden lotus fried with charcoal, add 2.5% cellulose equivalent to the weight of the golden lotus fried with charcoal Stir the enzyme for enzymolysis at 40-45°C for 2 hours, then raise the temperature to 90°C and keep for 15 minutes to inactivate the enzyme;

[0033] Step b. Centrifuge the enzymatically hydrolyzed material for 5 min at a rotational speed of 3500 r / min, take the supernatant, add ethanol until the ethanol volume percentage reaches 75%, let it stand for 24 h, and remove the precipitate. The feed liquid is freeze-dried to obtain.

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PUM

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Abstract

The invention relates to the technical field of traditional Chinese medicine extracts, in particular to a trollius chinensis bunge extract and application thereof, and an antibacterial composition containing the trollius chinensis bunge extract. The trollius chinensis bunge extract is prepared by carbonizing, enzymolysis and alcohol precipitation, and has a good antibacterial effect and mild drug properties. When the trollius chinensis bunge extract is combined with azithromycin for use, the antibacterial effect can be enhanced, a gastrointestinal reaction of the azithromycin can be relieved, and the discomfort of a patient in a drug administration process is reduced.

Description

technical field [0001] The invention relates to the technical field of extracts of traditional Chinese medicines, in particular to an extract of nasturtium and its application, and an antibacterial composition containing the extract of nasturtium. Background technique [0002] Nasturtium is a plant of the family Ranunculaceae Nasturtium, containing orientin, vitexin, 3,4-dimethoxybenzamide, liloamide, palmitic acid, alkaloids, coumarin, steroids, etc. The ingredients can clear away heat and detoxify, reduce swelling, improve eyesight, have antibacterial, antioxidative, anticancer, antihypertensive, anti-inflammatory and antispasmodic effects, and can be used clinically to treat acute and chronic tonsillitis, acute otitis media, acute tympanitis, and acute conjunctivitis Wait. [0003] In terms of antibacterial, heat-clearing and detoxifying Chinese medicines are often used in combination with Western medicines to improve efficacy. As a traditional Chinese medicine with hea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K33/34A61K31/7052A61K47/12A61P31/04
CPCA61K36/71A61K33/44A61K31/7052A61K47/12A61P31/04A61K2300/00
Inventor 周印军于海霞
Owner CHENGDE TIANYUAN PHARMACEUTICAL INDUSTRY CO LTD
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