RGD/PTX-coated ZIF-90 drug delivery system and preparation method thereof

A technology of ZIF-90 and delivery system, applied in drug combination, pharmaceutical formulation, antineoplastic drugs, etc., can solve the problems of low bioavailability and toxic side effects, achieve low toxicity and good effect, overcome allergic reactions, and increase release rate Effect
CN112999352APending Publication Date: 2021-06-22ANHUI UNIVERSITY OF TECHNOLOGY AND SCIENCE
4 Cites 5 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ANHUI UNIVERSITY OF TECHNOLOGY AND SCIENCE
Publication Date
2021-06-22

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses an RGD / PTX-coated ZIF-90 drug delivery system and a preparation method thereof, and belongs to the field of biological medicine. According to the drug delivery system, on the basis of the metal organic framework ZIF-90, aldehyde groups and amino groups of RGD are connected through a Schiff base reaction, PTX is entrapped through the adsorption effect, no extra chemical reagent is introduced in the whole process, and the drug delivery system is safer and more environmentally friendly. The preparation method is simple, the ZIF-90 and the RGD are stirred to obtain RGD / ZIF-90, then the RGD / ZIF-90 and the PTX are stirred together, and the RGD / PTX ZIF-90 composite material is obtained. According to the drug delivery system, aiming at the physiological characteristics of specific high expression of an alpha v beta 3 integrin receptor and low pH of tumor cells, RGD can target the tumor cells, and when the RGD reaches the vicinity of the tumor cells, the skeleton of ZIF-90 collapses, so that PTX is intensively released near the tumor cells, the anti-tumor activity is improved, the side effect of the drug can be reduced, and the drug delivery system has the advantages of strong anti-tumor effect, few side effects and high stability.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the field of anticancer drug delivery system, and in particular relates to a novel anticancer drug delivery system of RGD-paclitaxel-metal organic framework ZIF-90 (RGD / PTX@ZIF-90) and a preparation method thereof. Background technique

[0002] With the development of society and the change of people's lifestyle, cancer has become a major disease that endangers human health. How to effectively control and treat cancer has become an important public health problem to be solved urgently. Although traditional anticancer drugs can prolong the lifespan of some patients, they also face many challenges, such as short half-life, low bioavailability, high drug resistance, nonspecific distribution, and difficulty in crossing physiological barriers, etc.

[0003] Paclitaxel (PTX) is a common antineoplastic drug, which is widely used in the treatment of various forms of advanced and refractory cancers. It is a broad-spectrum antineoplasti...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More