2-(2-furoylamino) benzopyran compound and application thereof in pesticides
A technology of furocarboxamide and benzopyran, which is applied in the field of pesticides to achieve the effect of simple synthesis process, novel structure and good inhibitory effect
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Embodiment 1
[0069] compound Preparation of:
[0070] Add 10mmol of 4-fluoroacetophenone into 40mL of 10% NaOH aqueous solution, stir at 40-45°C for 30 minutes, then add 10mmol of 3,5-dichlorosalicylaldehyde to the reaction mixture, and continue the reaction for 10-15h , and check the completion of the reaction with a thin-layer silica gel plate (TLC). After the reaction was completed, the reaction mixture was poured into ice water, and the pH value of the solution was adjusted to neutrality with 10% hydrochloric acid solution. Solids were precipitated, filtered, and washed with distilled water. The obtained crude product was recrystallized from absolute ethanol to obtain Intermediate 1.
[0071] Dissolve 10mmol of self-made intermediate 1 in 20mL N,N-dimethylformamide (DMF), and add 10mmol K 2 CO 3 , and then slowly drop the mixed solution of 10mmol ethyl cyanoacetate and 20mL DMF into the above solution with a constant pressure dropping funnel. Under the condition of stirring at 40...
Embodiment 2
[0076] compound Preparation of:
[0077] Add 10mmol of 4-fluoroacetophenone into 40mL of 10% NaOH aqueous solution, stir at 40-45°C for 30 minutes, then add 10mmol of 3,5-dibromosalicylaldehyde to the reaction mixture, and continue the reaction for 10-15h , and check the completion of the reaction with a thin-layer silica gel plate (TLC). After the reaction was completed, the reaction mixture was poured into ice water, and the pH value of the solution was adjusted to neutrality with 10% hydrochloric acid solution. Solids were precipitated, filtered, and washed with distilled water. The obtained crude product was recrystallized from absolute ethanol to obtain Intermediate 1.
[0078] Dissolve 10 mmol of homemade intermediate 1 in 20 mL of DMF, and add 10 mmol of K 2 CO 3 , and then slowly drop the mixed solution of 10mmol ethyl cyanoacetate and 20mL DMF into the above solution with a constant pressure dropping funnel. Under the condition of stirring at 40-45°C, react for ...
Embodiment 3
[0083] compound Preparation of:
[0084] Add 10mmol of 4-chloroacetophenone into 40mL of 10% NaOH aqueous solution, stir at 40-45°C for 30 minutes, then add 10mmol of 5-chlorosalicylaldehyde to the reaction mixture, continue the reaction for 10-15h, and use thin A silica gel plate (TLC) was used to check whether the reaction was complete. After the reaction was completed, the reaction mixture was poured into ice water, and the pH value of the solution was adjusted to neutrality with 10% hydrochloric acid solution. Solids were precipitated, filtered, and washed with distilled water. The obtained crude product was recrystallized from absolute ethanol to obtain Intermediate 1.
[0085] Dissolve 10 mmol of homemade intermediate 1 in 20 mL of DMF, and add 10 mmol of K 2 CO 3 , and then slowly drop the mixed solution of 10mmol ethyl cyanoacetate and 20mL DMF into the above solution with a constant pressure dropping funnel. Under the condition of stirring at 40-45°C, react for ...
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