69 results about "Benzopyrans" patented technology

The invention relates to a coumarin-based fluorescent probe as well as a preparation method and application thereof in the aspect of HClO detection, and belongs to the technical field of HClO detection. The invention discloses a coumarin-based fluorescent probe W (O-(3-((2-morpholinyl ethyl) carbamoyl)-2-oxo-2hydrogen-benzopyran-7-yl) dimethyl thiocarbamate) prepared on the basis of an intramolecular charge transfer (ICT) mechanism, and a preparation method of the coumarin-based fluorescent probe W. The novel lysosome targeting fluorescent probe contains coumarin as a fluorophore, a morpholine group as a targeting group and a dimethyl thiocarbamate group as a recognition group, is a novel lysosome targeting fluorescent probe, and has excellent performances of high selectivity, low detection limit, low cytotoxicity, high resolution and the like in the aspect of HClO detection; the method can be used for detecting the content of endogenous and exogenous hypochlorous acid in living cells.

The invention provides an organic electroluminescent material and an organic electroluminescent device, the organic electroluminescent material has the following structure: M (LA) 2 (LB), the organic electroluminescent device provided by the invention adopts a doping material with a specific atomic structure, and one or more benzene ring groups are thickened on a benzopyran or benzothiapyran ring, so that the organic electroluminescent device can be used for preparing the organic electroluminescent device. By adjusting the size and shape of the spatial structure of the obtained substance, the molecular spatial configuration of the compound is extended, the electrochemical property of the compound is adjusted, and the symmetric dipole moment between molecules is improved, so that after the obtained organic compound is applied to the organic electroluminescent device, the device has the characteristics of long service life, high efficiency and low driving voltage.

The invention discloses a double-targeting probe and a preparation method and application thereof.The structure of the double-targeting probe is shown in the formula I. The double-targeting probe has the beneficial effects that SO2 can be monitored in the cell apoptosis process, the dynamic change of SO2 between mitochondria and lipid droplets in cells can be tracked, the core structure of the probe MLR is based on a coumarin part, and the core structure of the probe MLR can be used for detecting the apoptosis of the cells. The probe MLR is connected with a benzopyran cation structure specially designed for detecting SO2, SO2 generated in the death process of copper enables charges of a cation part in the probe MLR to be redistributed, a Michael addition reaction of SO2 and carbon-carbon double bonds is triggered, a fluorescence signal of the probe is changed, and the fluorescence signal is detected. The design of the probe provides a new tool for monitoring key biochemical changes in the copper death process, and is helpful for deeply understanding the molecular mechanism of copper death.

The present invention belongs to the field of phenolic resin synthesis, and specifically relates to a method for modifying dicyclopentadiene phenol resin with flavonoid biomass. The present invention uses a heat-resistant strongly acidic cation exchange resin as a catalyst and partially replaces phenol with daidzein to prepare the dicyclopentadiene phenol resin. The daidzein can effectively replace phenol, and the addition of daidzein can also improve the performance of the resin. The addition reaction of the benzopyran ring is conducive to the formation of cross-linking density. The appropriate amount of daidzein substitution can increase the degree of cross-linking. Finally, the resin synthesized by modifying the daidzein has good corrosion resistance, friction resistance, water absorption resistance, and thermal stability.

The disclosure relates to a benzopyrylium dye of the formula (I),in which R200, R201, R202, R203, R204, R205, R206, R207 and R208 independently of one another are each hydrogen, C1 to C16 alkyl, C4 to C7 cycloalkyl, C7 to C16 aralkyl, C6 to C10 (het)aryl, hydroxyl, C1 to C6 alkoxy, or dialkylamino, the dialkylamino being selected from the group consisting of diethylamino, dimethylamino, diisopropylamino, a six-membered saturated ring attached via the N of the amino group, which may additionally contain an N or O and may be substituted by nonionic arbitrary radicals, or a combination of at least two thereof, and / or R200 with R201 or R201 with R202 or R202 with R203 and / or R205 with R206 and / or R206 with R207 each independently of one another form a —CH═CH—CH═CH— bridge, and A is a —CH2— or a —CH2—CH2— bridge, where the anion Ann− has a molecular weight of ≥200 g / mol and does not contain a halogen atom.

The present application relates to a kind of 3-(2H-benzopyran-3-yl)-5-phenyl-1,2,4-oxadiazole derivative purposes, 3-(2H-benzopyran-3-yl)-5-phenyl-1,2,4-oxadiazole derivative structure as shown in formula I, this 3-(2H-benzopyran-3-yl)-5-phenyl-1,2,4-oxadiazole derivative has the potential to be developed as anti-radiation drug and antitumor drug.

To provide a novel compound derived from an extract of Agrimonia pilosa.SOLUTION: The invention provides a compound represented by Chemical Formula 3.SELECTED DRAWING: Figure 5

The present invention discloses a substituted 2H-benzopyran-3-formylanilide compound, a preparation method, and an application thereof. The structure of the substituted 2H-benzopyran-3-formylanilide compound is shown in Formula I. #imgabs0# The substituted 2H-benzopyran-3-formylanilide compound has the potential to be developed into an anti-radiation drug.

The invention discloses a method for detecting a nebivolol hydrochloride intermediate, namely 6-fluoro-3, 4-dihydro-alpha-[[(phenyl methyl) amino] methyl]-2H-1-benzopyran-2-methanol and an isomer of the nebivolol hydrochloride intermediate, namely 6-fluoro-3, 4-dihydro-alpha-[[(phenyl methyl) amino] methyl]-2H-1-benzopyran-2-methanol. The method can effectively elute, separate and quantitatively detect each component through optimization of chromatographic conditions, is high in sensitivity, strong in specificity and high in accuracy, and provides accurate, rapid and effective quality control for nebivolol hydrochloride products and a preparation process.

The application relates to the technical field of liquid flow batteries, and discloses a low-temperature-resistant liquid flow battery electrolyte, a preparation method thereof and a zinc-bromine liquid flow battery. The low-temperature-resistant liquid flow battery electrolyte comprises water, an electrolyte salt, a supporting electrolyte, a 2-phenyl benzopyran type cationic additive and an alcohol solvent. The 2-phenyl benzopyran type cationic additive has a double regulation function, can synchronously solve the problems of polybromide shuttling effect and zinc negative electrode irreversibility, and can construct a high-performance zinc-bromine liquid flow battery. The alcohol solvent has little influence on the electrolyte conductivity and viscosity, can reduce the freezing point of the electrolyte, and can improve the reaction kinetics of zinc under low-temperature conditions. The interaction between the alcohol solvent and the 2-phenyl benzopyran type cationic additive enables the zinc-bromine liquid flow battery to operate more stably and efficiently under low-temperature conditions, and solves the problem of low energy efficiency of the zinc-bromine liquid flow battery under low-temperature conditions in the prior art.

The invention belongs to the field of ophthalmic medicines, and particularly relates to application of a 9-ether-7H-furo [3, 2-g] benzopyran-7-ketone component in preparation of a medicine for protecting optic nerve injury, and the 9-ether-7H-furo [3, 2-g] benzopyran-7-ketone component is a compound of 9-ether-7H-furo [3, 2-g] benzopyran-7-ketone. The component of the benzopyran-7-ketone is a compound with a structure # imgabs0 # as shown in a formula A and at least one of pharmaceutically acceptable crystals, solvates and co-crystals of the compound. Researches show that the compound with the structure of the formula A can accidentally have RGCs protection activity and can be used for preparing medicines for treating optic nerve injury caused by various causes.

The present invention discloses a method for preparing a (R)-benzopyran-4-ol compound. The method comprises the following steps: in the presence of a catalyst 8, subjecting a compound represented by Formula II and a hydrogen donor to a reduction reaction as shown below to obtain a compound represented by Formula I. The method has high chiral purity and high yield, and provides a new method for synthesizing a key chiral intermediate of ticlopidine.

The invention relates to the technical field of fluorescence detection and molecular probes, in particular to a fluorescent probe for detecting bivalent palladium as well as a preparation method and application of the fluorescent probe. The fluorescent probe for detecting bivalent palladium is a compound with a structure shown in a formula (I). The fluorescent probe provided by the invention takes benzopyran as a fluorescent parent nucleus and propynyl as a recognition site, and is novel in structure. When the fluorescent probe is used for divalent palladium detection, the fluorescent probe has the characteristics of single selective recognition, high sensitivity and low detection limit (0.18 mu M) on divalent palladium, and the fluorescence intensity of the fluorescent probe and the concentration of divalent palladium are in a good linear relationship within the range of 0-40 mu M. Meanwhile, an application experiment verifies that when the fluorescent probe is used for detecting the divalent palladium in the traditional Chinese medicinal materials, the adding standard recovery rate ranges from 90.8% to 106.4%. Therefore, the fluorescent probe disclosed by the invention has a wide application prospect in the fields of bivalent palladium detection reagents and rapid detection of heavy metals in traditional Chinese medicinal materials.

Provided is an antibacterial application of a 3-phenyl-4H-benzopyran-4-one compound. Specifically, provided is use of a 3-phenyl-4H-benzopyran-4-one compound represented by formula I in the preparation of a product for inhibiting the proliferation of mycobacteria or treating diseases or conditions mediated by the proliferation of mycobacteria, and in the preparation of an in vitro reagent for inhibiting cytochrome bcc-aa3 oxidase and cytochrome bd oxidase of mycobacteria. Further disclosed are use of a 3-phenyl-4H-benzopyran-4-one compound represented by formula I' in the preparation of a product for improving the sensitivity of mycobacteria to cytochrome bcc-aa3 oxidase inhibitors, and a related composition. The compound is used for targeting a new target, and provides a new direction for the inhibition of mycobacterium tuberculosis and the treatment of related diseases.

The present invention provides a benzopyran-type flavonoid compound, its preparation method and application, and a pharmaceutical preparation, belonging to the field of pharmaceutical chemistry technology. The present invention provides a benzopyran-type flavonoid compound having a structure represented by Formula I or Formula II. The benzopyran-type flavonoid compound provided by the present invention targets members of the SWEET protein family in plants, selectively inhibiting the sugar transport activity of plant SWEET proteins while also exhibiting broad-spectrum antibacterial activity. These combined effects enhance the broad-spectrum disease resistance of plants. #imgabs0#

The present invention relates to the field of medical technology, and specifically discloses a near-infrared fluorescent diagnostic and therapeutic probe that can monitor ERα protein degradation in real time, as well as its preparation method and application. The highly ERα-targeting fluorophore 2-(6-hydroxy-2-(4-hydroxystyryl)-4H-benzopyran-4-subunit) malononitrile is used as a warhead that specifically binds to the target protein, methyl VHL is used as a ligand to recruit E3 ligase, and carbon chains of different lengths are used as linkers to design and synthesize a series of near-infrared fluorescent diagnostic and therapeutic probes that can monitor ERα protein degradation in real time. The diagnostic and therapeutic NIR probe of the present invention can not only effectively degrade ERα protein, but also exhibit excellent anti-proliferative activity. This innovative study successfully integrated PROTAC technology with a fluorescent probe targeting ERα for the first time, realizing real-time visualization of ERα protein degradation in MCF-7 cells. These results provide strong support for the potential application prospects of this type of compound in the treatment of breast cancer and expand the application field of PROTAC technology.

This invention belongs to the field of new drugs, specifically relating to a pyran derivative, B63, and its use in the preparation of drugs for use against largemouth bass frog iridescence virus. The invention provides the use of B63, its derivatives, or pharmaceutically acceptable salts thereof, or substances containing B63, its derivatives, or pharmaceutically acceptable salts as active ingredients, in the preparation of products for use against largemouth bass frog iridescence virus. B63 exhibits both in vitro and in vivo anti-largemouth bass frog iridescence virus activity and is a potential drug candidate for use against largemouth bass frog iridescence virus.

The invention relates to a silibinin derivative as well as a preparation method and application thereof, and belongs to the technical field of chemistry. The invention relates to a silibinin derivative, which is 6-sulfonated silibinin sodium sulfonate, the chemical name of the silibinin derivative is 2, 3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-hydroxymethyl-6-(3, 5, 7-trihydroxy-4-oxo benzopyran-2-yl) benzodioxane-6-sodium sulfonate, the molecular formula of the silibinin derivative is C25H21NaO13S, and the molecular weight of the silibinin derivative is 584.49. Sulfonic acid groups with hydrophilicity are introduced into different parts of the silibinin to prepare different types of silibinin sodium sulfonate, so that the solubility of the silibinin sodium sulfonate in water is enhanced, the pharmacokinetic characteristics of the silibinin are improved from the pharmacokinetic level, the affinity and biological activity of the silibinin to organisms are improved, and the application prospect of the silibinin sodium sulfonate is widened. The compound is further prepared into an injection for clinical treatment, and has important clinical drug treatment value.

The present disclosure relates to the technical field of pharmaceutical preparations, and provides a pharmaceutical preparation containing pranoprofen and a preparation method thereof. 5H-[1]-benzopyrano[2,3-b]pyridine-5-one is subjected to a reduction reaction and a dehydroxylation conversion to obtain 5H-[1]-benzopyrano[2,3-b]pyridine; the 5H-[1]-benzopyrano[2,3-b]pyridine is subjected to an acylation reaction to obtain a 2-halogenated propionyl substituted benzopyranopyridine intermediate; the 2-halogenated propionyl substituted benzopyranopyridine intermediate is treated to obtain crude pranoprofen; the crude pranoprofen is subjected to recrystallization to obtain pranoprofen wet crystals, and the pranoprofen wet crystals are added into an aqueous dispersion solvent to obtain the pharmaceutical preparation containing pranoprofen. The adverse effects of impurity accumulation in the synthesis process in the early stage are reduced, and the dispersion stability of the preparation in the later stage is improved, so that the dispersion stability of the preparation from the early stage to the later stage is realized.

The invention provides a benzopyran nitrile derivative as well as a preparation method and application thereof, and belongs to the technical field of fluorescent probes. The benzopyran nitrile derivative provided by the invention has a structure as shown in a formula I, is a near-infrared fluorescent probe taking benzopyran nitrile as a mother nucleus structure and a borate group as a detection group, and can realize detection of hydrogen peroxide in an alkaline microenvironment. # imgabs0 #

A method of treating or preventing pain and / or inflammation and / or controlling pyrexia or fever, comprising administering (2S)-7-tert-butyl-6-chloro-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid, or a pharmaceutically acceptable salt thereof or a hydrate thereof.

Provided herein are crystalline forms of 3-({[(4R)-7-{methyl[4-(propan-2-yl)phenyl]amino}-3,4-dihydro-2H-1-benzopyran-4-yl]methyl}amino)pyridine-4-carboxylic acid, L-lysine salt, as histone demethylase inhibitors. Also provided herein are pharmaceutical compositions comprising such crystalline forms.

The invention discloses a benzopyran enantiomer and its preparation method and application. The present invention extracts and separates a pair of benzopyran enantiomers from the rhizome of Gentiana macrophylla, and evaluates the hepatoprotective activity of Gentiana macrophylla benzopyran by detecting the inhibitory effect of the benzopyran enantiomer on acetaminophen-induced human hepatocyte (L-O2) damage in vitro. It was found that the benzopyran enantiomer has good hepatoprotective activity. The preparation method of the benzopyran enantiomer provided by the present invention is simple to operate and low in cost, and the obtained benzopyran has high purity, a clear structure, and a variety of potential application values, which lays the foundation for the development of the medicinal value of Gentiana macrophylla benzopyran.

The present invention belongs to the field of new drugs and specifically relates to a 4H-benzo[b]pyran derivative B77 and its use in treating carp herpesvirus type II. The present invention provides the use of a substance comprising B77 or a pharmaceutically acceptable salt thereof as an active ingredient in the preparation of a product for treating carp herpesvirus type II. B77 exhibits anti-carp herpesvirus type II activity both in vivo and in vitro, making it a potential candidate drug for treating carp herpesvirus type II.

The present invention relates to a carbon nanotube dispersion comprising carbon nanotubes, a first dispersant comprising a nitrogen atom, a second dispersant comprising a substituted benzopyran-based compound, and a solvent, and a method for preparing the same, wherein the substituted benzopyran-based compound contained in the second dispersant contains at least three hydroxyl groups.

The present invention discloses a benzopyran derivative, a synthesis method, and an application thereof. Trifluoroacetone containing a benzene ring and different heterocycles and a substituted salicylaldehyde are used as raw materials, DMSO is used as a solvent, and a reflux reaction is performed to generate a crude benzopyran derivative with different substituents. The crude product is post-treated to obtain the benzopyran derivative. The reaction is tracked by TLC or liquid chromatography, and the reaction process is simple and easy to operate. Eighteen synthesized compounds were subjected to antifungal activity experiments to determine the antifungal activity of the compounds against Fusarium graminearum, Rhizoctonia solani, Fusarium moniliforme, and Fusarium oxysporum. At 200 ppm, thiophene dibromopyrone had the highest inhibition rate against Fusarium graminearum, at 98.84%; unsubstituted dichloropyrone had the highest inhibition rate against Fusarium graminearum, at 66.08%; pyridine dichloropyrone had the highest inhibition rate against Fusarium oxysporum, at 71.07%; and pyridine dichloropyrone had the highest inhibition rate against Fusarium moniliforme, at 69.12%. The benzopyran derivatives synthesized by the present invention will show good application prospects in various fields such as medicine, organic synthesis, biosensing and optoelectronic materials.

Provided herein are crystalline forms of 3-({[(4R)-7-{methyl [4-(propan-2-yl) phenyl] amino}-3, 4-dihydro-2H-1-benzopyran-4-yl] methyl} amino) pyridin-4-carboxylic acid L-lysine salt as inhibitors of histone demethylase. Also provided herein are pharmaceutical compositions comprising such crystalline forms.

The invention discloses a novel 6, 6, 5-tricyclic compound structure, and in particular relates to a 3a-cyano-4-carbonyl-3-aryl-2, 3, 3a, 4-tetrahydrochroman [3, 4-c] pyrrolidine-9bH-1-carboxylic ester derivative, which is called benzopyran [3, 4-c] pyrrolidine derivative for short. In addition, the invention also discloses a preparation method of the benzopyran [3, 4-c] pyrrolidine derivative, which comprises the following steps: by using a transition metal catalyst, dissolving 3-cyano coumarin and a glycine imine ester derivative as raw materials in an organic solvent according to a certain proportion, and carrying out [3 + 2] 1, 3-dipolar cycloaddition reaction to obtain the benzopyran [3, 4-c] pyrrolidine derivative. The catalytic synthesis method is simple and convenient to operate, the used raw materials are all commercial reagents, the reaction condition is mild, the raw material application range is wide, the product yield is high, and certain stereoselectivity is achieved. The novel 6, 6, 5-tricyclic compound comprises coumarin and pyrrolidine structures with potential biological activity, and the synthetic method provides a synthetic scheme for the compound with potential biological activity and has important application value in the field of drug research and development.