172 results about "Benzopyrans" patented technology

The present invention is directed to novel benzopyran derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders related to potassium channel.

The invention discloses a novel preparation method of pranoprofen. The novel preparation method of the pranoprofen has the advantages of being high in yield, having less impurities, and being safe andenvironmentally friendly. The novel preparation method of the pranoprofen comprises the following steps that step 1, 5H-[1]-benzopyran[2,3-b]pyridine and propionyl chloride are directly acylated; step 2, bromination is carried out; step 3, potassium tert-butoxide or sodium tert-butoxide is used for hydrolysis, and finally, rearrangement is carried out to obtain the pranoprofen.

This invention provides 6H-[1]benzopyrano[4,3-b]quinoline compounds having the formula I: The invention further provides compositions including the compounds, methods for the use of the compounds, and the methods of preparation of the compounds.

A therapeutic compound has a modified phenolic compound of the general formula (I)

The invention relates to dibenz, naphthopyrans and dibenz and dibenz spiropyran compound, and the method for preparing the same. Said method comprises: dibenzofuran or naphthofurans reacting with lithium with molar ration being 1:2-2.4, opening loop, reacting with aldehyde, ketone, ester or amide at temperature of -70 to -80 Deg. C, the molar ratio between dibenzofuran or naphthofurans and aldehyde, ketone, ester or amide is 1:0.7-1, dewatering and closing loop, and getting final product. The invention is characterized by cheap raw material, simple process, high productivity, and multiple kinds of products.

The present invention discloses liquid crystal compounds having dibenzopyran derivatives with cycloalkyl groups, and preparation methods and application thereof. The liquid crystal compounds having dibenzopyran derivatives with cycloalkyl terminal groups, shown in formula I, exhibit better miscibility and a very large negative dielectric constant, compared to those having a flexible alkyl chain as a terminal group, therefore the compounds of the present invention, shown in formula I, may improve the miscibility of liquid crystal compounds and broaden the application range of liquid crystal mixtures. In addition, the compounds may also increase the negative dielectric constants of liquid crystal mixtures, having an important application value.

The invention discloses a benzopyranone compound, as well as a preparation method and an application thereof, belonging to the field of synthesis of medicaments. The method comprises the following steps of: based on 1, 4-benzopyrandione and p-tert-butyl cyclohexyl acetaldehyde as raw materials, performing condensation reaction to get 3-((4-tert-butyl-cyclohexyl) dimethylene)-1, 4-benzopyrandione. The invention further discloses the method for preparing buparvaquone by utilizing the compound. The method has the characteristics of simple synthesis method, effect of avoiding the use of AgNO3, high total yield and the like.

The invention relates to a composition comprising a lupin total extract consisting of a lupin sugar extract, comprising at least 50 % galactooligosacharides by weight, in relation to the weight of dry matter, and a lupin peptide extract. The composition can also contain a chromane derivative or a chromene derivative. The invention also relates to a pharmaceutical and/or cosmetic composition comprising said lupin total extract, used advantageously as an anti-inflammatory agent, which repairs the cutaneous barrier and heals, used particularly in the prevention and/or treatment of erythemas.

Provided are benzopyran compounds of formula I, for example, pomiferin-3′,4′-dimethyl ether, and the use of such compounds and compositions thereof to modulate (e.g., inhibit) melanogenesis and pigmentation.

wherein R³, R⁴, R⁵, R⁶, R⁷ and R⁸ are described herein. Also provided are plant extracts containing a compound of formula I, and the use of such a plant extract to modulate (e.g., inhibit) melanogenesis and pigmentation. The compound or plant extract may be prepared as pharmaceutical and cosmetic compositions, and may be used for the prevention and treatment of conditions that are related to aberrant melanogenesis activity.

The invention provides a method for manufacturing a smart light-controlled insulating window membrane, which aims to solve the problems of low efficiency for blocking ultraviolet and infrared rays, low speed of light-controlled color-changing and recovery, poor using comfortable feeling and the like in the prior art. According to the technical scheme, the method is characterized by comprising the following steps: manufacturing a first functional membrane; manufacturing a second functional membrane; combining the first functional membrane and the second functional membrane; coating a transparent wearing layer; and coating a pressure-sensitive adhesive layer and a composite release type PET membrane, wherein the top surface of a first optical PET membrane which is subjected to corona treatment or coated with a PU easy bonding layer is coated with a metal oxide insulating coating mixed with stannic oxide and antimony trichloride particles, and is coated with an intelligent light-controlled color-changing coating mixed with tungsten trioxide particles and benzopyran when the first functional membrane is manufactured; and when the second functional membrane is manufactured, an ultraviolet absorber is added in the process of forming a second optical PET membrane, or a nichrome metal insulating layer is plated to the bottom of the second optical PET membrane.

A preparing method of tetrahydro benzopyran derivatives is disclosed. The method adopts cyclodextrin as a catalyst, adopts aromatic aldehyde, dimedone and malononitrile as raw materials and adopts water, ethanol or methanol as a solvent. A reaction is performed at 15-30 DEG C, and the tetrahydro benzopyran derivatives can be prepared by recrystallization or column chromatography separation after the reaction is finished. The method is mild in reaction conditions, short in process steps, simple and convenient in operation, low in cost and high in yield, and has a good industrial application prospect.

The invention discloses a preparing method of (E)-N'-arylmethylene-4-(coumarin-3-yl)thiazole-2-hydrazide compound and its application. A formula (I) of the compound is shown as below. The preparing method includes: making salicylic aldehyde and ethyl acetoacetate into 3-acetylindole-2H-chromene-2-one, allowing bromization, cyclization and hydrazinolysis to obtain 4-(2-oxo-2H-chromene-3-yl)thiazole-2-hydrazine, and allowing the 4-(2-oxo-2H-chromene-3-yl)thiazole-2-hydrazine to react with substituted benzaldehydes to obtain the target compound. The compound can serve as a raw material for antiseptic medicine; the preparing method has the advantages that the raw materials are simple and easy to obtain and operating is convenient.

The invention discloses a preparation method of buparvaquone and belongs to the field of medicine synthesis. The preparation method comprises the following step of: with 1,4-benzopyran diketone and p-tert-butylcyclohexyl acetaldehyde as raw materials, performing condensation and rearrangement to prepare pharmaceutical grade buparvaquone. According to the preparation method of buparvaquone, provided by the invention, use of an expensive catalyst AgNO3 is avoided, and a total synthesis yield is increased to about 65% as compared with the prior art. The route is green and environment-friendly, and easy to industrialize.

The present invention is directed to methods of stimulating hair growth by administering particular benzopyran compounds.

The invention relates to a preparation method and an application of 2-(4-beta-D-allose pyranoside-phenyl)-2,3-dihydroquinoline-4(1H) (1) and 2-(4-(2,3,4,6-tetrabenzyl)-beta-D-allose pyranoside-phenyl)-2,3-benzodihydropyran (2). The invention discloses helicide derivatives with a central nervous system improving function, and a preparation method thereof. The compounds provided by the invention have good sedative, sleep-promoting, and convulsion-inhibiting functions. The compounds are collected in a Year 2000 version of Pharmacopoeia of PRC with a medicine name of helicide tablets. The helicide derivative novel medicines are represented by chemical formulas (1) and (2), wherein R1 can be hydrogen and acetyl, and R2 can be semicarbazide, hydroxylamine, and methoxylamine. Acording to the helicide derivatives provided by the invention, a plant active monomer helicide with sedative, sleep-promoting, and convulsion-inhibiting functions is adopted as a matrix compound, structural modification is carried out according to a medicine efficacy molecular principle, and compounds with high activities for improving central nervous system functions are designed and prepared.

The invention discloses an extract enriched in benzopyran lactone as well as a preparation method and medical application of the extract. The extract provided by the invention is enriched in gastrodinA, gastrodin B and gastrodin C, wherein the sum of contents of the three is not lower than 90%; or the extract is enriched in gastrodin A, gastrodin B, gastrodin C and gastrodin D, and the sum of contents of the four is not lower than 85%. The extract is clear in monomer composition, high in content and capable of easily controlling the quality, the renal toxicity of aristolochic acid can be reduced, and the extract can be used for preparing a single Chinese herb containing aristolochic acid or a traditional Chinese medicine tract or an attenuated drug of a traditional Chinese medicine compound preparation. According to the preparation method of the extract, disclosed by the invention, separation methods that are difficult to operate on a large scale in a factory, such as column chromatography on silica gel, do not need to be repeatedly used, the extract with the total content 85% or higher of effective monomer composition can be prepared by only passing through a primary macroporousresin and combining with pH regulation and control, and the preparation method is capable of easily realizing industrialization, simple in operation and low in cost.

The invention relates to the field of building coatings and paints. The invention discloses a photochromic stone-like coating for a building external wall. The coating is prepared from the following raw materials in parts by weight: 5.8-6 parts of 1-allyl-6-chlorospiro[2H-1-benzopyran-2,2'-indoline], 45-50 parts of acrylic acid, 5-10 parts of N, N-dimethylformamide, 30-35 parts of methyl methacrylate, 0.5-0.6 part of an emulsifier, 0.2-0.3 part of an initiator, 0.025-0.03 part of a leveling agent, 0.025-0.03 part of a defoamer, 0.055-0.06 part of an electronic conductive agent, 0.085-0.09 partof an amine compound, 2.5-3.0 parts of natural colored quartz sand and 0.025-0.03 part of magnesium aluminum silicate. The preparation method comprises the following steps: adding a micromolecular compound 1-allyl-6-chlorospiro[2H-1-benzopyran-2,2'-indoline] with a photochromic functional group into a polymer main chain through a copolymerization method so that the photochromic stone-like coatingis prepared. Compared with a color-changing coating obtained by physically mixing color-changing powder in the prior art, the photochromic stone-like coating has the advantages that the color-changing performance is more durable, and the photochromic stone-like coating can adapt to outdoor environments.

The invention concerns substituted amino isoxazoline derivatives, more in particular tricyclic dihydrobenzopyranoisoxazoline, dihydroquinolinoisozazoline, dihydronaphthalenoisoxazoline and dihydrobenzothiopyranoisoxazoline derivatives substituted on the phenylpart of the tricyclic moiety with primary, secondary and/or tertiary amino groups, according to Formula (I)

wherein X=CH₂, N—R⁷, S or O, R¹, R² and R³ are certain specific substituents, with the proviso that at least one of R¹ and R² is an amino radical of formula N—R¹⁰R¹¹ wherein R¹⁰ and R¹¹ are each a variety of radicals, Pir is an optionally substituted piperidyl or piperazyl radical and R³ represents an optionally substituted aromatic homocyclic or heterocyclic ring system including a partially or completely hydrogenated hydrocarbon chain of maximum 6 atoms long with which the ring system is attached to the Pir radical and which may contain one or more heteroatoms selected from the group of O, N and S; a process for their preparation, pharmaceutical compositions comprising them and their use as a medicine, in particular for the treatment of depression and/of anxiety and disorders of body weight. The compounds according to the invention have surprisingly been shown to have a serotonin (5-HT) reuptake inhibitor activity in combination with additional α₂-adrenoceptor antagonist activity and show a strong anti-depressant activity without being sedative. Compounds according to the invention are also suitable for treating depression, anxiety and body weight disorders. The invention also relates to novel combination of substituted amino isoxazoline derivatives according to the invention with antidepressants, anxiolytics and/or antipsychotics to improve efficacy and/or onset of action.