31 results about "Benzopyrans" patented technology

The disclosure relates to a benzopyrylium dye of the formula (I),in which R200, R201, R202, R203, R204, R205, R206, R207 and R208 independently of one another are each hydrogen, C1 to C16 alkyl, C4 to C7 cycloalkyl, C7 to C16 aralkyl, C6 to C10 (het)aryl, hydroxyl, C1 to C6 alkoxy, or dialkylamino, the dialkylamino being selected from the group consisting of diethylamino, dimethylamino, diisopropylamino, a six-membered saturated ring attached via the N of the amino group, which may additionally contain an N or O and may be substituted by nonionic arbitrary radicals, or a combination of at least two thereof, and / or R200 with R201 or R201 with R202 or R202 with R203 and / or R205 with R206 and / or R206 with R207 each independently of one another form a —CH═CH—CH═CH— bridge, and A is a —CH2— or a —CH2—CH2— bridge, where the anion Ann− has a molecular weight of ≥200 g / mol and does not contain a halogen atom.

The application relates to the technical field of liquid flow batteries, and discloses a low-temperature-resistant liquid flow battery electrolyte, a preparation method thereof and a zinc-bromine liquid flow battery. The low-temperature-resistant liquid flow battery electrolyte comprises water, an electrolyte salt, a supporting electrolyte, a 2-phenyl benzopyran type cationic additive and an alcohol solvent. The 2-phenyl benzopyran type cationic additive has a double regulation function, can synchronously solve the problems of polybromide shuttling effect and zinc negative electrode irreversibility, and can construct a high-performance zinc-bromine liquid flow battery. The alcohol solvent has little influence on the electrolyte conductivity and viscosity, can reduce the freezing point of the electrolyte, and can improve the reaction kinetics of zinc under low-temperature conditions. The interaction between the alcohol solvent and the 2-phenyl benzopyran type cationic additive enables the zinc-bromine liquid flow battery to operate more stably and efficiently under low-temperature conditions, and solves the problem of low energy efficiency of the zinc-bromine liquid flow battery under low-temperature conditions in the prior art.

The invention relates to the technical field of fluorescence detection and molecular probes, in particular to a fluorescent probe for detecting bivalent palladium as well as a preparation method and application of the fluorescent probe. The fluorescent probe for detecting bivalent palladium is a compound with a structure shown in a formula (I). The fluorescent probe provided by the invention takes benzopyran as a fluorescent parent nucleus and propynyl as a recognition site, and is novel in structure. When the fluorescent probe is used for divalent palladium detection, the fluorescent probe has the characteristics of single selective recognition, high sensitivity and low detection limit (0.18 mu M) on divalent palladium, and the fluorescence intensity of the fluorescent probe and the concentration of divalent palladium are in a good linear relationship within the range of 0-40 mu M. Meanwhile, an application experiment verifies that when the fluorescent probe is used for detecting the divalent palladium in the traditional Chinese medicinal materials, the adding standard recovery rate ranges from 90.8% to 106.4%. Therefore, the fluorescent probe disclosed by the invention has a wide application prospect in the fields of bivalent palladium detection reagents and rapid detection of heavy metals in traditional Chinese medicinal materials.

Provided is an antibacterial application of a 3-phenyl-4H-benzopyran-4-one compound. Specifically, provided is use of a 3-phenyl-4H-benzopyran-4-one compound represented by formula I in the preparation of a product for inhibiting the proliferation of mycobacteria or treating diseases or conditions mediated by the proliferation of mycobacteria, and in the preparation of an in vitro reagent for inhibiting cytochrome bcc-aa3 oxidase and cytochrome bd oxidase of mycobacteria. Further disclosed are use of a 3-phenyl-4H-benzopyran-4-one compound represented by formula I' in the preparation of a product for improving the sensitivity of mycobacteria to cytochrome bcc-aa3 oxidase inhibitors, and a related composition. The compound is used for targeting a new target, and provides a new direction for the inhibition of mycobacterium tuberculosis and the treatment of related diseases.

The present disclosure relates to the technical field of pharmaceutical preparations, and provides a pharmaceutical preparation containing pranoprofen and a preparation method thereof. 5H-[1]-benzopyrano[2,3-b]pyridine-5-one is subjected to a reduction reaction and a dehydroxylation conversion to obtain 5H-[1]-benzopyrano[2,3-b]pyridine; the 5H-[1]-benzopyrano[2,3-b]pyridine is subjected to an acylation reaction to obtain a 2-halogenated propionyl substituted benzopyranopyridine intermediate; the 2-halogenated propionyl substituted benzopyranopyridine intermediate is treated to obtain crude pranoprofen; the crude pranoprofen is subjected to recrystallization to obtain pranoprofen wet crystals, and the pranoprofen wet crystals are added into an aqueous dispersion solvent to obtain the pharmaceutical preparation containing pranoprofen. The adverse effects of impurity accumulation in the synthesis process in the early stage are reduced, and the dispersion stability of the preparation in the later stage is improved, so that the dispersion stability of the preparation from the early stage to the later stage is realized.

A method of treating or preventing pain and / or inflammation and / or controlling pyrexia or fever, comprising administering (2S)-7-tert-butyl-6-chloro-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid, or a pharmaceutically acceptable salt thereof or a hydrate thereof.

Provided herein are crystalline forms of 3-({[(4R)-7-{methyl[4-(propan-2-yl)phenyl]amino}-3,4-dihydro-2H-1-benzopyran-4-yl]methyl}amino)pyridine-4-carboxylic acid, L-lysine salt, as histone demethylase inhibitors. Also provided herein are pharmaceutical compositions comprising such crystalline forms.

The invention discloses a novel 6, 6, 5-tricyclic compound structure, and in particular relates to a 3a-cyano-4-carbonyl-3-aryl-2, 3, 3a, 4-tetrahydrochroman [3, 4-c] pyrrolidine-9bH-1-carboxylic ester derivative, which is called benzopyran [3, 4-c] pyrrolidine derivative for short. In addition, the invention also discloses a preparation method of the benzopyran [3, 4-c] pyrrolidine derivative, which comprises the following steps: by using a transition metal catalyst, dissolving 3-cyano coumarin and a glycine imine ester derivative as raw materials in an organic solvent according to a certain proportion, and carrying out [3 + 2] 1, 3-dipolar cycloaddition reaction to obtain the benzopyran [3, 4-c] pyrrolidine derivative. The catalytic synthesis method is simple and convenient to operate, the used raw materials are all commercial reagents, the reaction condition is mild, the raw material application range is wide, the product yield is high, and certain stereoselectivity is achieved. The novel 6, 6, 5-tricyclic compound comprises coumarin and pyrrolidine structures with potential biological activity, and the synthetic method provides a synthetic scheme for the compound with potential biological activity and has important application value in the field of drug research and development.

The application provides a chromone-modified o-phenanthroline polypyridine Ru(II) series compound and a preparation method and application thereof, the preparation method synthesizes an intermediate A by taking 1,10-o-phenanthroline-5,6-diketone and 6-substituted-4-oxo-4H-benzopyran-3-formaldehyde as raw materials, then the intermediate A is heated to reflux in ethylene glycol solvent and cis-[Ru(2,2'-dipyridine)2Cl2]·2H2O at 120 DEG C for 6h, after the system is cooled to room temperature, an excess amount of a saturated aqueous solution of potassium hexafluorophosphate is added, after a precipitate is separated out, the filter cake is washed with clean water, and the final product is obtained after drying. The synthesis method is simple and easy to operate without steps such as column chromatography.

The invention discloses synthesis of a novel drug small molecular formula (1) containing a coumarin structure and an antitumor activity research formula (1), wherein R is shown in the specification, and R1, R2 and R3 are respectively independent H, OCH3 or COOCH3. 4-hydroxyacetophenone is used as a starting raw material to obtain an important intermediate compound; secondly, enabling an intermediate obtained by carrying out nucleophilic substitution reaction (acylation reaction) on chloroacetyl chloride and different amine compounds to react with 7-diethylamino-3-(4-hydroxybenzoyl)-2-ketone to obtain a drug small molecule containing a coumarin structure, namely a target compound. A CCK-8 experiment is carried out on a target compound, and a conclusion is drawn that methoxy substituted (7b, 7c and 7d): ortho-position methoxy and meta-position methoxy can remarkably inhibit the activity of Hepg-2 cells. Wherein the meta-methoxy group can also significantly inhibit the activity of HeLa cells. (7e, 7f, 7g) substituted by methyl benzoate: only meta-position has strong activity on HeLa. Cyano substitution (7h): the compound has relatively remarkable activity on HeLa and Hepg-2 at the same time.

The application discloses a preparation method of a benzopyran derivative containing hexafluoroisopropyl ester, which comprises the following steps: reacting propargyl ether compound, hexafluoroisopropanol and N-iodosuccinimide at room temperature for 15 min, then adding palladium acetate, tris(2-furyl)phosphine, formic acid, acetic anhydride and potassium phosphate to react at 60 DEG C for 24 hours, and after the reaction is completed, post-treatment is carried out to obtain the benzopyran derivative containing hexafluoroisopropyl ester. The preparation method uses hexafluoroisopropanol as a reactant and a promoter, uses formic acid as a carbonyl source, has mild reaction conditions, simple operation, a wide functional group tolerance range of a substrate and high reaction efficiency. According to actual needs, a plurality of benzopyran derivatives containing hexafluoroisopropyl ester can be synthesized, and the method is convenient to operate and wide in practicability.

The invention discloses a lysosome targeted copper ion fluorescent probe with an AIE (aggregation-induced emission) effect, which is obtained by taking 7-(diphenylamino)-2-oxo-2H-benzopyran-3-carboxylic acid (I) and 8-aminoquinoline (II) as raw materials and reacting and synthesizing under the action of 2-(7-azabenzotriazole)-N, N, N ', N'-tetramethylurea hexafluorophosphate and triethylamine. The chemical structural formula of the fluorescent probe is shown as a formula (III), and the fluorescent probe has an AIE effect, has the advantages of high selectivity and high sensitivity on Cu < 2 + > recognition and the like, and can be used for effectively detecting Cu < 2 + > in an environmental water sample; besides, the probe has good biocompatibility, can be positioned in a lysosome, and is applied to real-time fluorescence imaging monitoring of Cu < 2 + > concentration change in an autophagy process caused by starvation or a chemical inducer in living cells and zebra fish bodies; the invention provides a copper ion detection tool with excellent performance, which has huge potential in the fields of environmental monitoring and life science research.

The present invention relates to a compound or pharmaceutically acceptable salt, hydrate, solvate, N-oxide, stereoisomer, diastereoisomer, enantiomer, atropisomer, dimer or polymorph for use in medicine comprising the following chemical formula (I): wherein R 1 , R 2 and R 3 are selected independently of each other; R 1 is selected from aryl or heterocycle; R 2 is selected from H, alkyl, aryl, alkoxy, halogen, hydroxyl, amine, carbonyl or heterocycle; R 3 is selected from H or (II).

This invention relates to the field of luminescent materials technology, specifically to a photochromic Pt(II) complex, its preparation method, and its applications. The photochromic Pt(II) complex has the structure shown in formula Pt-A. This invention primarily uses fluorene as a planar chiral framework, and obtains a chiral photochromic Pt(II) complex by modifying the 2-sites of the planar chiral framework. Furthermore, the rigid structure of the photochromic Pt(II) complex of this invention can hinder the ring-closing process of the benzopyran unit, thereby effectively increasing the stability of the chromophore of the chromotropic group and solving the problem of low stability of the chromophores in existing benzopyran-based photochromic compounds.

The present application relates to a kind of chiral 2-amino benzopyran derivatives with bactericidal activity, and its preparation method and purposes.The chiral 2-amino benzopyran derivatives of the present application have the structure shown in general formula I, and the synthesis process of the present application is simple, and has certain inhibitory effect on plant pathogenic fungi.

This invention discloses the application of a 4-methylenemalonium-benzopyran derivative fluorescent dye in biofluorescence imaging. The 4-methylenemalonium-benzopyran derivative fluorescent dye, as shown in formula (I), is obtained by a Knoevenagel condensation reaction of 9-aldehyde julonidine with 2-(2-methyl-4H-benzopyran-4-methylene)malonium under piperidine catalysis. The preparation method of this compound is simple, the reaction conditions are mild, and the yield is high. The 4-methylenemalonium-benzopyran derivative fluorescent dye exhibits excellent two-photon absorption properties and can be applied to confocal fluorescence imaging of HeLa cells and two-photon excitation microscopy of HEK cells. Furthermore, this compound has good biocompatibility and can achieve mitochondrial localization, showing great promise for applications in molecular biology and medicine.

The invention relates to a fixed-point propynylation modified 3-deoxy anthocyanin derivative, the molecular formula of the derivative is C21H15ClO4, and the chemical name of the derivative is 2-(4-hydroxyphenyl)-5, 7-bis (propyl-2-alkyne-1-yloxy) benzopyran chloride. The invention provides a preparation method of the 3-deoxy anthocyanin derivative, and effectively solves the problems that natural 3-deoxy anthocyanin is low in content and difficult to extract. The invention provides application of the 3-deoxy anthocyanin derivative in preparation of drugs for treating cervical cancer. The invention also provides a pharmaceutical composition for treating cervical cancer. The pharmaceutical composition comprises an effective dose of 3-deoxy anthocyanin derivative and 5-fluorouracil. The 3-deoxy anthocyanin derivative can be used as an effective anti-tumor compound for preparing a medicine for treating cervical cancer or an adjuvant therapy medicine for synergistically enhancing the anti-tumor activity of 5-fluorouracil.

The invention provides an antibacterial application of a 3-phenyl-4H-benzopyran-4-ketone compound, and relates to a preparation method of the compound. Specifically, the invention provides application of a 3-phenyl-4H-benzopyran-4-ketone compound shown as a formula I in preparation of an article for inhibiting mycobacterium proliferation or treating diseases or symptoms mediated by mycobacterium proliferation and in preparation of an in-vitro reagent for inhibiting cytochrome bcc-aa3 oxidase and cytochrome bd oxidase of mycobacterium, and application of the 3-phenyl-4H-benzopyran-4-ketone compound in preparation of an in-vitro reagent for inhibiting the cytochrome bcc-aa3 oxidase and the cytochrome bd oxidase of the mycobacterium. The invention further discloses application of the 3-phenyl-4H-benzopyran-4-ketone compound shown in the formula I'in preparation of an article for improving the sensitivity of mycobacteria to a cytochrome bcc-aa3 oxidase inhibitor, and a related composition of the 3-phenyl-4H-benzopyran-4-ketone compound. The compound provided by the invention is used for targeting a new target, and provides a new direction for inhibition of mycobacterium tuberculosis and treatment of related diseases.

Disclosed are substituted tetrahydro-(5H)-chromen-5-one and hexahydro-(5H)-chromen-5-one derivatives of formula (I) possessing woody, peppery notes which is reminiscent of Rotundone. A method of their production and consumer products comprising them is also disclosed.

A class of compounds that have a pyrazine structure, specifically disclosed is a compound represented by formula, isomers or pharmaceutically acceptable salts thereof, and an application thereof in the preparation of CRAC inhibitors.

This invention discloses a polycyanobenzopyran compound, its derivatives, their synthesis methods, and applications. The polycyanobenzopyran compound is a tricyano-substituted benzopyran compound, possessing antibacterial and anti-inflammatory functions, and has potential application value in the biomedical field. This invention also provides derivatives of the above-mentioned polycyanobenzopyran compound, using the polycyanobenzopyran compound as an electron acceptor to construct D-π-A type red to near-infrared fluorescent molecules. These molecules exhibit good fluorescence properties and can be used as mechanotropic fluorescent color-changing molecules or to achieve CN-... ‑ Rapid fluorescence detection. This invention also provides a method for preparing the above-mentioned polycyanobenzopyran compounds. This invention utilizes o-hydroxyacetophenone and malononitrile as starting materials and ammonium acetate as a catalyst to obtain polycyanobenzopyran compounds in a one-step reaction. The preparation method has significant advantages such as being green and safe, simple to operate, having a wide range of substrate applicability, and excellent yield.

The application discloses a preparation method of a benzopyran derivative containing a thioester structure, and comprises the following steps: adding a propargyl ether compound, hexafluoroisopropanol and N-iodosuccinimide into a solvent to react at 50-70 DEG C for 0.5-5 h, then adding a sulfonyl chloride compound, a palladium catalyst, a ligand, a carbonyl molybdenum and a base to react at 80-100 DEG C for 20-28 hours, and after the reaction is completed, post-treatment is carried out to obtain the benzopyran derivative containing the thioester structure; the preparation method uses the sulfonyl chloride compound as a reactant and a sulfur source, uses the carbonyl molybdenum as a carbonyl source, has mild reaction conditions, simple operation, a wide functional group tolerance range of a substrate and high reaction efficiency. According to actual needs, various benzopyran derivatives containing the thioester structure can be synthesized, and the method is convenient to operate and wide in practicability.

The invention discloses a preparation method and application of an optical switch fluorescent antifouling coating for preventing counterfeiting under seawater, and the coating is prepared from green fluorescent dye 2-allyl-6-(dimethylamino)-1H-benzo [de] isoquinoline-1, 3 (2H)-diketone (ANA), optical switch dye 2-(3 ', 3'-dimethyl-6-nitro spiro [benzopyran-2, 2 '-diketone), organic solvent and organic solvent. The preparation method comprises the following steps: by taking 2, 2 '-indoline]-1'-yl) ethyl undecylene-10-enoic acid ester (ASP) and Dow Corning Sylgard 184 as raw materials, covalently binding a green fluorescent dye donor and an optical switch dye receptor into a polydimethylsiloxane network through a Michael addition reaction, constructing a light-induced fluorescence resonance energy transfer system, and introducing a lubricating agent by swelling low-viscosity silicone oil, thereby obtaining the light-induced fluorescence resonance energy transfer material. The coating disclosed by the invention integrates high contrast, rapid photoresponse, reversibility, antifouling property and reconfigurability, is particularly suitable for product anti-counterfeiting application in a complex seawater environment, and solves the technical problem that the existing photoswitch fluorescent material is easy to lose efficacy in the seawater environment.

Provided herein are pharmaceutical formulations of the KDM4 inhibitor 3-({[(4r)-7-{methyl[4-(propan-2-yl)phenyl]amino}-3,4-dihydro-2h-1-benzopyran-4-yl]methyl}amino)pyridine-4-carboxylic acid.

The invention relates to chemistry and pharmacology, specifically to a synthetic biologically active substance—7,9-dibromo-2,4-dioxo-1,2,3,4-tetrahydrochromeno[2,3-d]-pyrimidinium-10 acetate or succinate formula 1:1Where X−═CH3COO− or HOOCCH2CH2COO−,as well as its tautomeric, hydrated forms, solvate, complex compounds, adducts and salt forms, possessing antimicrobial activity, and the ability to penetrate bacterial biofilms. The compound is intended for the treatment of bacterial infections of the oropharynx, skin, and mucous membranes, urinary system, implants, respiratory system, gastrointestinal tract. osteomyelitis, sepsis, nosocomial and wound infections.

The application discloses a preparation method of a benzopyran derivative containing an amide structure, which comprises the following steps: reacting propargyl ether compound, hexafluoroisopropanol and N-iodosuccinimide at 60 DEG C for 1 h, then adding a nitro compound, palladium acetate, 2-diphenylphosphine-biphenyl, carbonyl molybdenum, potassium carbonate and water to react at 100 DEG C for 24 h, and after the reaction is completed, post-treatment is carried out to obtain the benzopyran derivative containing the amide structure. The preparation method uses the nitro compound as a reactant and a nitrogen source, and uses the carbonyl molybdenum as a carbonyl source, has mild reaction conditions, simple operation, a wide functional group tolerance range of a substrate and high reaction efficiency. According to actual needs, various benzopyran derivatives containing the amide structure can be synthesized, and the method is convenient to operate and wide in practicability.

The invention relates to a synthesis method of 6-bromo-5-amino-3, 4-dihydro-2h-1-benzopyran-8-formic acid and a derivative of the 6-bromo-5-amino-3, 4-dihydro-2h-1-benzopyran-8-formic acid, and belongs to the technical field of preparation of medical intermediates. The invention discloses a synthesis method of 6-bromo-5-amino-3, 4-dihydro-2h-1-benzopyran-8-formic acid and a derivative thereof, and the synthesis method comprises the following synthesis steps: dissolving a compound 1 in toluene, and reacting with 1, 3 dihalogenated propane to generate a compound 2; the compound 2 is dissolved in bromobenzene, a compound 3 is generated under the action of cuprous bromide and ferric bromide, X1 and X2 are halogens, and X1 and X2 may be the same. The invention solves the technical problems of long reaction route, high cost and high risk in the existing synthesis method, realizes high-efficiency and low-cost preparation of 6-bromo-5-amino-3, 4-dihydro-2h-1-benzopyran-8-formic acid and derivatives thereof, and is safe in condition and suitable for large-scale production.

This invention discloses a coumarin-based multifunctional fluorescent probe for the simultaneous detection of hydrazine, carbon monoxide, and viscosity, as well as its preparation method and application. The fluorescent probe is: 2-cyano-2-(2-[(4-nitrophenyl)methyl]-1H-pyrrolo-1-onthiol-2-yl)vinyl]-5-[2-(diethylamino)phenyl]thiophene-2(5H)-one. This invention utilizes 7-(diethylamino)-4-oxo-4H-thieno[2,3]benzopyran-2-carboxaldehyde as a raw material, which undergoes a condensation reaction with 4-pyridineacetonitrile to obtain 2-[4-(diethylamino)phenoxy]-5-[(2-cyano-2-(pyridin-4-yl)vinyl]thiophene-3(2H)-one. This is then quaternized with p-nitrobenzyl bromide to obtain 2-cyano-2-(2-[(4-nitrophenyl)methyl]-1H-pyrrolo-1-onthiol-2-yl)vinyl]-5-[2-(diethylamino)phenyl]thiophene-2(5H)-one. This compound reacts with hydrazine, carbon monoxide, and viscosity, producing green, orange, and red fluorescence. It can serve as a multifunctional fluorescent probe for the simultaneous detection of hydrazine, carbon monoxide, and viscosity, exhibiting advantages such as good selectivity and high sensitivity, demonstrating promising application prospects.