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A kind of medicine containing Garciniaceae components and the application of preparing medicine for alleviating autoimmunity

An autoimmune, useful technology, applied in the field of biomedicine, which can solve problems such as lack of systematic research

Active Publication Date: 2022-01-11
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is currently a lack of systematic research on garcinia xanthone E and garsonwo D

Method used

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  • A kind of medicine containing Garciniaceae components and the application of preparing medicine for alleviating autoimmunity
  • A kind of medicine containing Garciniaceae components and the application of preparing medicine for alleviating autoimmunity
  • A kind of medicine containing Garciniaceae components and the application of preparing medicine for alleviating autoimmunity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] The dry suspension or capsule of embodiment 1 garcinia xanthone E and preparation method

[0015] Materials: Garcinia xanthone E 650mg, sodium carboxymethylcellulose 40mg, hydroxypropyl methylcellulose 31 mg, microcrystalline cellulose 79 mg (wet granulation of soft materials prepared from starch slurry).

[0016] Preparation of dry suspension or capsule: Grind garcinia xanthone E, sodium carboxymethylcellulose, hydroxypropyl methylcellulose, and microcrystalline cellulose through a 100-mesh sieve and mix evenly, then add 10% starch slurry to prepare Soft material, soft material is granulated with 18 mesh sieve, dried at 60°C, granulated with 16 mesh sieve, divided into aluminum foil bags to make bagged oral dry suspension or divided into capsule shells to make oral capsules.

Embodiment 2

[0017] Embodiment 2 Injection and preparation method of garcinia xanthone E

[0018] Materials: Gambogexanthone E 120mg, Poloxamer 188 0.3g, ethanol 0.7g, water for injection to 100ml.

[0019] Preparation of injection: add ethanol to 50 ml of water for injection, add poloxamer 188 to the hydroalcoholic solution to dissolve, add gambogexanthone E to the hydroalcoholic solution containing poloxamer 188 and stir to dissolve, Add the remaining amount of water for injection to make up to 100ml.

Embodiment 3

[0020] Embodiment 3 Garcinia xanthone E, Jiashengwo D compound dry suspension or capsule and preparation method

[0021] Materials: garcinia xanthone E 325mg, Garsonwool D 325mg, sodium carboxymethylcellulose 40mg, hydroxypropyl methylcellulose 31 mg, microcrystalline cellulose 79 mg (wet granulation of soft materials prepared from starch slurry) .

[0022] Preparation of dry suspension or capsule: Grind garcinia xanthone E, Galvano D, sodium carboxymethyl cellulose, hydroxypropyl methyl cellulose, and microcrystalline cellulose through a 100-mesh sieve and mix evenly, add 10% starch slurry to prepare soft material, soft material is granulated with 18 mesh sieve, dried at 60°C, granulated with 16 mesh sieve, divided into aluminum foil bags to make oral dry suspension in bags or divided into capsule shells to make Oral capsules.

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Abstract

The invention belongs to the field of biomedicine, and in particular relates to a drug containing active ingredients of Garciniaceae plants and its application in preparing drugs for alleviating autoimmune diseases. The pharmaceutical active ingredient of the present invention is one or two of gambogee xanthone E and garsenwo D. Experiments have shown that gambogee xanthone E and garzenwo D have improvement effects on various autoimmune disease models, and have the activity of regulating cAMP, which are suitable for improving various autoimmune diseases.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a drug containing active ingredients of Garciniaceae plants and its application in preparing drugs for alleviating autoimmune diseases. Background technique [0002] Autoimmune disease is a disease caused by the proliferation and activation of lymphocytes that recognize self-antigens, and the loss of tolerance to endogenous self-antigens, which leads to the immune system's immune response to itself. Such diseases include autoimmune liver injury (Autoimmune liver injury, AII), systemic lupus erythematosus (SLE), psoriasis (Psoriasis, PS), multiple sclerosis (Multiple sclerosis, MS), autoimmune Encephalomyelitis (Autoimmune encephalomyelitis, AE), etc. Due to the lack of autoantigen information and the complexity of disease pathogenesis, there is currently no cure for autoimmune diseases, and drug treatment is only used to relieve symptoms and delay the development of the di...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/415A61K31/352A61P37/06A61P17/00A61P17/06A61P19/02A61P29/00
CPCA61K31/415A61K31/352A61P37/06A61P17/00A61P17/06A61P19/02A61P29/00A61K2300/00
Inventor 王垚张聪
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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