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Middle ear anti-adhesion membrane and preparation method thereof

An anti-adhesion film, middle ear technology, applied in ear treatment, other medical devices, drug devices, etc., can solve the problems of polyethylene glycol allergy, secondary adhesion of the affected area, etc., to improve the anti-adhesion effect and eliminate inflammation and disease effects

Pending Publication Date: 2021-07-09
BIOVAS (WUHAN) MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the middle ear anti-adhesion drug sustained release system has the following defects: 1) the degradation of the diaphragm may cause secondary adhesion of the affected area; 2) some people are allergic to polyethylene glycol

Method used

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  • Middle ear anti-adhesion membrane and preparation method thereof

Examples

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preparation example Construction

[0047]As another aspect of the present invention, a method for preparing the above-mentioned middle ear anti-adhesion film of the present invention comprises the following steps:

[0048] 1) Take the adhesive and the antibiotic according to the quantity requirements, and then prepare them into a solution with a concentration of 0.5-5wt%, and mix them thoroughly to form a homogeneous solution;

[0049] 2) Coat the homogeneous solution obtained in step 1) on both sides of the central support substrate in turn, and then coat the polylactic acid-glycolic acid copolymer diaphragm, blow dry at 37-60°C for 0.5-24 hours and take it out to obtain semi-finished products;

[0050] 3) The outer surface of the semi-finished product obtained in step 2) is coated with antibiotics again to obtain the middle ear anti-adhesion membrane of the present invention.

Embodiment 1

[0052] A middle ear anti-adhesion membrane, comprising:

[0053] Central support substrate 1,

[0054] an adhesive and an antibiotic layer 2 evenly coated on both sides of the central support substrate 1, and

[0055] an outer polylactic acid-glycolic acid copolymer diaphragm 3 bonded to the adhesive and the antibiotic layer 2, and

[0056] The surface of the polylactic acid-glycolic acid copolymer membrane 3 is loaded with antibiotics 4 .

[0057] The central support substrate is made of polyether ether ketone;

[0058] The thickness of the central support substrate accounts for 50% of the overall thickness, and its shape is rectangular;

[0059] The adhesive coated on both sides of the central support substrate is genipin;

[0060] The antibiotic coated on both sides of the central support substrate is vancomycin;

[0061] The concentration of the adhesive is 0.5wt%, and it is evenly coated on both sides of the central support substrate;

[0062] The concentration of t...

Embodiment 2

[0072] A middle ear anti-adhesion membrane, comprising:

[0073] Central support substrate 1,

[0074] an adhesive and an antibiotic layer 2 evenly coated on both sides of the central support substrate 1, and

[0075] an outer polylactic acid-glycolic acid copolymer diaphragm 3 bonded to the adhesive and the antibiotic layer 2, and

[0076] The surface of the polylactic acid-glycolic acid copolymer membrane 3 is loaded with antibiotics 4 .

[0077] The central support substrate is a mixed material of silica gel and bacterial cellulose membrane;

[0078] The thickness of the central supporting base material accounts for 90% of the overall thickness, and the shape is circular;

[0079] The adhesive coated on both sides of the central support substrate is chitosan;

[0080] The antibiotics coated on both sides of the central support substrate are vancomycin and tetracycline;

[0081] The concentration of the adhesive is 5wt%, evenly coated on both sides of the central suppor...

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Abstract

The invention discloses a middle ear anti-adhesion membrane and a preparation method thereof, and the middle ear anti-adhesion membrane comprises a central support base material, an adhesive and an antibiotic layer which are uniformly coated on two sides of the central support base material, and an outer polylactic acid-glycolic acid copolymer membrane which is adhered outside the adhesive and the antibiotic layer, wherein antibiotics are loaded on the surface of the polylactic acid-glycolic acid copolymer membrane. The ear anti-adhesion membrane is properly cut according to the specific condition of a patient during clinical use, injured tissue can be isolated from normal serous membranes, the situation that new tissue adheres to other surrounding normal serous membranes in the healing process of a wound is avoided, the ear anti-adhesion membrane can play a role in replacing the eardrum of the patient to transmit sound to a certain extent, and the problem of secondary injury caused by implantation of the cartilage tissue is avoided.

Description

technical field [0001] The invention belongs to the technical field of biological materials, and in particular relates to a middle ear anti-adhesion film and a preparation method thereof. Background technique [0002] As a common clinical phenomenon, adhesions after ear surgery can lead to serious clinical complications, such as adhesive otitis media, secretory otitis media, and tympanosclerosis, which increase the difficulty of reoperation and the potential risk of further complications. Adhesions often accompany surgery and usually occur during tissue repair when separated tissue surfaces adhere together, which can be interpreted as attachments between tissues and organs, and become postoperative complications when adhesions affect normal tissue function. At present, there are no mature products dedicated to anti-adhesion in middle ear surgery at home and abroad. There are only 6 clinical research reports related to the silicone tympanic support sheet. Although it shows th...

Claims

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Application Information

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IPC IPC(8): A61F11/00A61M31/00A61L31/04A61L31/06A61L31/14A61L31/16
CPCA61F11/00A61M31/002A61L31/06A61L31/042A61L31/16A61L31/148A61L31/14A61L2300/406A61L2300/604C08L67/04
Inventor 王海军陶忠王国才王昊飞林龑侯昭晖
Owner BIOVAS (WUHAN) MEDICAL TECH CO LTD
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