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Polypeptide aggregate molecule as well as preparation method and application thereof
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A technology of aggregates and molecules, applied in the field of biomedicine, can solve the problems of lack of synthetic raw materials, etc., and achieve the effect of long residence time and inhibition of migration
Active Publication Date: 2021-07-13
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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For example, Hitosugi et al. substituted tyrosine at position 105 of PKM2 with phenylalanine, which prevented PKM2 from being phosphorylated and fixed in a highly active tetramer conformation, resulting in a lack of synthetic raw materials and thus inhibiting tumor growth (see Hitosugi T,Kang S,Heiden M V,et al.TyrosinePhosphorylation Inhibits PKM2 to Promote the Warburg Effect andTumor Growth[J].Science Signaling,2009,2(97):ra73.)
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Embodiment 1
[0052] This embodiment provides a polypeptide aggregate molecule, the structure of which is shown in Formula I.
[0053] The preparation method of the polypeptide aggregate molecule comprises the following steps:
[0070] Specific operation method: take the polypeptide synthesized in step (1), sodium ascorbate (0.4eq), coppersulfate pentahydrate (0.4eq), and triphenylamine AIE molecule (2eq) shown in formula II are dissolved in 5mL DMSO, and pass into Under nitrogen protection, react overnight, after the reaction is completed, dialyze and freeze-dry to obtain the aggregate molecule.
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Abstract
The invention relates to a polypeptide aggregate molecule as well as a preparation method and an application thereof. The polypeptide aggregate molecule comprises serine, an enzyme specific hydrolysis part, an assembly driving part and an aggregation-induced emission part, and the serine, the enzyme specific hydrolysis part, the assembly driving part and the aggregation-induced emission part are connected to form the polypeptide aggregate molecule. The polypeptide aggregate molecule can be specifically hydrolyzed in tumor cells, the action of serine and dimer PKM2 is exposed, the polypeptide aggregate molecule is promoted to be converted into tetramer PKM2, and therefore tumor inhibition is achieved, in addition, the aggregation-induced luminescence effect is achieved through assembling, the progress and migration of tumors can be monitored in real time, and meanwhile the long-acting retention effect is achieved.
Description
technical field [0001] The invention belongs to the technical field of biomedicine and relates to a polypeptide aggregate molecule and its preparation method and application. Background technique [0002] Prostatecancer is a malignant tumor that occurs in the prostate tissue of men and is the result of abnormal growth of prostatic alveolar cells. There are many treatment methods for prostatecancer. According to different treatment methods, the current treatment methods include chemotherapy, surgery, cryotherapy, radiotherapy, radioactive seed implantation treatment, etc. For cancers that tend to spread throughout the body and advanced cancers that have metastasized, Chemotherapy is the main treatment method at present, however, the resistance of cancer cells to chemotherapeutic drugs often leads to the failure of chemotherapy. [0003] For traditional organic materials, the fluorescence intensity will decrease as the concentration increases. In recent years, a series of a...
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