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Gliclazide sustained release tablet

A technology of gliclazide and sustained-release tablets, applied in the field of sustained-release tablets for the treatment of diabetes, can solve the problems of complicated production process of osmotic pump controlled-release tablets, unfavorable for large-scale production, etc.

Pending Publication Date: 2021-07-16
BEIJING WINSUNNY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the production process of the osmotic pump controlled-release tablet is complicated, which is not conducive to large-scale industrial production.

Method used

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  • Gliclazide sustained release tablet
  • Gliclazide sustained release tablet
  • Gliclazide sustained release tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036]

[0037] Preparation:

[0038] a. Mix gliclazide, calcium hydrogen phosphate and maltodextrin evenly to obtain a mixture;

[0039] b. Wet granulate the above mixture, and granulate to obtain drug granules;

[0040] c. Mix the above drug granules with polyammonium methacrylate evenly, and press into tablets.

Embodiment 2

[0042]

[0043] Preparation:

[0044] a. Mix gliclazide, calcium hydrogen phosphate and maltodextrin evenly to obtain a mixture;

[0045] b. Wet granulate the above mixture, and granulate to obtain drug granules;

[0046] c. Mix the above drug granules with polyammonium methacrylate evenly, and press into tablets.

Embodiment 3

[0048]

[0049] Preparation:

[0050] a. Gliclazide, calcium hydrogen phosphate, calcium sulfate and sorbitol are mixed uniformly to obtain a mixture;

[0051] b. Wet granulate the above mixture, and granulate to obtain drug granules;

[0052] c. Mix the above drug granules with polyammonium methacrylate evenly, and press into tablets.

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PUM

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Abstract

The invention relates to a gliclazide sustained-release tablet which specifically comprises gliclazide, a skeleton material, a diluent and a pore-foaming agent, and the skeleton material is methacrylic acid copolymer. The gliclazide sustained release tablet provided by the invention has relatively stable dissolution and release properties, does not have a burst release phenomenon, and has a dissolution curve consistent with that of commercially available drugs; meanwhile, the gliclazide sustained release tablet disclosed by the invention has better quality stability, simple preparation process, low production cost and is suitable for industrial large-scale production.

Description

technical field [0001] The invention relates to a sustained-release tablet for treating diabetes, in particular to a sustained-release tablet of gliclazide, and a preparation method of the sustained-release tablet. Background technique [0002] Diabetes has become one of the five diseases with the highest morbidity and mortality in the world, especially in developing countries such as China and Africa. Once diabetes is not well controlled, it will cause complications, leading to failure and lesions in the kidneys, eyes, feet and other parts, and it cannot be cured. Commonly used oral hypoglycemic drugs include sulfonylureas and biguanides. Gliclazide is a commonly used sulfonylurea hypoglycemic drug. Gliclazide has a stronger effect, and its mechanism is to selectively act on Pancreatic β cells promote insulin secretion and increase insulin release after eating glucose, inhibiting glycogen production and output. It has hypoglycemic effect on adults with diabetes, and can r...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K31/64A61K47/32A61P3/10
CPCA61K31/64A61K9/2027A61P3/10
Inventor 黄玉锋王帅彭小玲杨文涛王峰峰耿玉先产运霞
Owner BEIJING WINSUNNY PHARMA CO LTD
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